CDK3 and FRS2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CDK3	FRS2
Description		cyclin dependent kinase 3	fibroblast growth factor receptor substrate 2
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GO Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Cytoplasm	Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Adherens Junction Endomembrane System Membrane
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Cyclin Binding Protein Serine Kinase Activity	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Fibroblast Growth Factor Receptor Binding Neurotrophin TRKA Receptor Binding Protein Binding Phosphatase Activator Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle DNA Damage Response Signal Transduction Cell Population Proliferation Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Gene Expression G0 To G1 Transition Negative Regulation Of Notch Signaling Pathway Cell Division	Gastrulation With Mouth Forming Second Organ Induction Lens Development In Camera-type Eye Ventricular Septum Development Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway G Protein-coupled Receptor Signaling Pathway Neuroblast Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Anterior/posterior Axis Specification, Embryo Forebrain Development Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Lens Placode Formation Involved In Camera-type Eye Formation Regulation Of Epithelial Cell Proliferation Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis Lens Fiber Cell Development Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Cardiac Muscle Cell Differentiation
Pathways			PI3K Cascade PIP3 activates AKT signaling Frs2-mediated activation Frs2-mediated activation Signaling by ALK Constitutive Signaling by Aberrant PI3K in Cancer PI-3K cascade:FGFR1 FRS-mediated FGFR1 signaling PI-3K cascade:FGFR2 FRS-mediated FGFR2 signaling FRS-mediated FGFR3 signaling PI-3K cascade:FGFR3 FRS-mediated FGFR4 signaling PI-3K cascade:FGFR4 Negative regulation of FGFR1 signaling Negative regulation of FGFR2 signaling Negative regulation of FGFR3 signaling Negative regulation of FGFR4 signaling Signaling by FGFR2 in disease Signaling by FGFR4 in disease Signaling by FGFR1 in disease Signaling by FGFR3 in disease RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling RET signaling Activated NTRK2 signals through FRS2 and FRS3 Activated NTRK2 signals through FRS2 and FRS3 RND2 GTPase cycle RND1 GTPase cycle Signaling by ALK fusions and activated point mutants
Drugs
Diseases
GWAS			Complete remission in asthma ( 29786918) Heel bone mineral density ( 30598549) Height ( 18391951 20881960 23563607 25282103 25429064 31562340) Hip circumference adjusted for BMI ( 25673412) Logical memory (delayed recall) in normal cognition ( 29274321) Microalbuminuria ( 31511532) Response to antidepressants (symptom remission) ( 29160301) Response to diuretic therapy ( 18591461) Thyroid stimulating hormone levels ( 32769997) Urinary albumin-to-creatinine ratio ( 31511532)
Interacting Genes		38 interacting genes: APP CABLES1 CABLES2 CCNA2 CCNC CCND3 CCNE1 CCNE2 CCNH CCNI CDC37 CDKN1A CDKN1B CDKN3 CKS2 E2F1 E2F2 E2F3 FOXP2 FRS2 KIR3DL1 LHX3 LHX4 MEOX2 NEDD4L NELFA OR2G6 OTX2 PAX5 PAX6 PAX8 PPARA RACGAP1 RB1 SPDYE4 STN1 TRIM55 TRIM63	28 interacting genes: BECN1 CBL CDK3 CRK DDR1 FGFR1 GAB1 GRB2 INSR KDR MAPK1 MAPK3 NCK1 NTRK1 NTRK2 NTRK3 PAK1 PIN1 PRKCI PRKCZ PTPN11 PTPRF RET RND1 RPS6 SOS1 SRC YJU2
Entrez ID		1018	10818
HPRD ID		00446	06372
Ensembl ID		ENSG00000250506	ENSG00000166225
Uniprot IDs		Q00526	L7RTG7 Q8WU20
PDB IDs		7XQK 8H4R	1XR0 2MFQ
Enriched GO Terms of Interacting Partners?		Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cyclin-dependent Protein Kinase Holoenzyme Complex Protein Kinase Binding Regulation Of Primary Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Chromatin Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleus DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Sequence-specific DNA Binding Rb-E2F Complex Regulation Of Macromolecule Metabolic Process Regulation Of Mitotic Cell Cycle Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Metabolic Process DNA-binding Transcription Factor Activity DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cell Division Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Cell Population Proliferation Regulation Of Gene Expression Epithelial Cell Apoptotic Process Negative Regulation Of Cardiac Muscle Tissue Regeneration Medial Motor Column Neuron Differentiation Regulation Of Phosphorus Metabolic Process Regulation Of Cell Cycle Phase Transition DNA Binding Positive Regulation Of Mitotic Cell Cycle Cyclin E1-CDK2 Complex Regulation Of Protein Kinase Activity	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of MAPK Cascade Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cellular Component Organization Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Protein Kinase Activity Regulation Of Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Response To Growth Factor Signal Transduction Kinase Activity Regulation Of Cell Communication Regulation Of Signaling Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Cellular Component Organization Positive Regulation Of MAPK Cascade Cell Surface Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Protein Tyrosine Kinase Activity Cell Migration Ephrin Receptor Signaling Pathway Protein Phosphorylation Epidermal Growth Factor Receptor Signaling Pathway Phosphorylation Cell Motility Protein Autophosphorylation ERBB Signaling Pathway Regulation Of Neuron Projection Development Positive Regulation Of Neuron Projection Development Phosphotyrosine Residue Binding Positive Regulation Of Cell Projection Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Peptidyl-tyrosine Phosphorylation Regulation Of Cell Projection Organization Cell Development Regulation Of Cell Population Proliferation Positive Regulation Of Cell Migration ATP Binding Receptor Complex Ephrin Receptor Binding Positive Regulation Of Cell Motility Neurotrophin Signaling Pathway Nucleotide Binding Transferase Activity Positive Regulation Of Locomotion
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