CDK3 and E2F2

Number of citations of the paper that reports this interaction (PubMedID 8846921)
0

Data Source:
HPRD (in vivo)

		CDK3	E2F2
Description		cyclin dependent kinase 3	E2F transcription factor 2
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GO Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Cytoplasm	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Rb-E2F Complex RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Cyclin Binding Protein Serine Kinase Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle DNA Damage Response Signal Transduction Cell Population Proliferation Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Gene Expression G0 To G1 Transition Negative Regulation Of Notch Signaling Pathway Cell Division	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Sprouting Angiogenesis Lens Fiber Cell Apoptotic Process
Pathways			Oxidative Stress Induced Senescence Oncogene Induced Senescence Cyclin D associated events in G1 Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
Drugs
Diseases
GWAS			Eosinophil count ( 27863252 32888494) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Lymphocyte count ( 32888494) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Red blood cell count ( 32888494) Red cell distribution width ( 28957414 27863252 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Severe insulin-resistant type 2 diabetes ( 34737425) Sum eosinophil basophil counts ( 27863252) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 32888494 27863252)
Interacting Genes		38 interacting genes: APP CABLES1 CABLES2 CCNA2 CCNC CCND3 CCNE1 CCNE2 CCNH CCNI CDC37 CDKN1A CDKN1B CDKN3 CKS2 E2F1 E2F2 E2F3 FOXP2 FRS2 KIR3DL1 LHX3 LHX4 MEOX2 NEDD4L NELFA OR2G6 OTX2 PAX5 PAX6 PAX8 PPARA RACGAP1 RB1 SPDYE4 STN1 TRIM55 TRIM63	20 interacting genes: ARID3A ATAD2 BCAR1 BRD2 CCNF CDK3 FHL2 GIT2 GNB5 GRB2 KMT5A RB1 RNF144A RYBP SP1 SPIB TFDP1 TFDP2 UCHL5 YY1
Entrez ID		1018	1870
HPRD ID		00446	02692
Ensembl ID		ENSG00000250506	ENSG00000007968
Uniprot IDs		Q00526	Q14209
PDB IDs		7XQK 8H4R	1N4M
Enriched GO Terms of Interacting Partners?		Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cyclin-dependent Protein Kinase Holoenzyme Complex Protein Kinase Binding Regulation Of Primary Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Chromatin Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleus DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Sequence-specific DNA Binding Rb-E2F Complex Regulation Of Macromolecule Metabolic Process Regulation Of Mitotic Cell Cycle Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Metabolic Process DNA-binding Transcription Factor Activity DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cell Division Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Cell Population Proliferation Regulation Of Gene Expression Epithelial Cell Apoptotic Process Negative Regulation Of Cardiac Muscle Tissue Regeneration Medial Motor Column Neuron Differentiation Regulation Of Phosphorus Metabolic Process Regulation Of Cell Cycle Phase Transition DNA Binding Positive Regulation Of Mitotic Cell Cycle Cyclin E1-CDK2 Complex Regulation Of Protein Kinase Activity	Positive Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Regulation Of RNA Biosynthetic Process Chromatin Nucleoplasm Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Chromatin Remodeling Rb-E2F Complex Regulation Of Cell Cycle Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Chromatin Organization G1/S Transition Of Mitotic Cell Cycle Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Transcription Corepressor Activity Regulation Of Voltage-gated Calcium Channel Activity Ino80 Complex Positive Regulation Of Telomere Maintenance In Response To DNA Damage Cell Cycle G1/S Phase Transition Regulation Of DNA Strand Elongation Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Cell Division Positive Regulation Of Biosynthetic Process Transcription Regulator Complex Transcription Factor Binding Protein Localization To Chromosome DNA Damage Response PcG Protein Complex Transcription Coregulator Activity Positive Regulation Of Metabolic Process BHLH Transcription Factor Binding Regulation Of Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Mitotic Cell Cycle Phase Transition Regulation Of Macromolecule Metabolic Process Chromosome Organization Cell Cycle Phase Transition Positive Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Guanyl-nucleotide Exchange Factor Adaptor Activity Regulation Of G1/S Transition Of Mitotic Cell Cycle
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