CDK3 and CDKN1B

Number of citations of the paper that reports this interaction (PMID 9811456)
7

Data Source:
HPRD (in vivo)

		CDK3	CDKN1B
Gene Name		cyclin-dependent kinase 3	cyclin-dependent kinase inhibitor 1B (p27, Kip1)
Image
Gene Ontology Annotations	Cellular Component		Nucleus Nucleoplasm Cytoplasm Endosome Cytosol Cul4A-RING E3 Ubiquitin Ligase Complex
	Molecular Function	Cyclin-dependent Protein Serine/threonine Kinase Activity ATP Binding	Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Transforming Growth Factor Beta Receptor, Cytoplasmic Mediator Activity Protein Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Protein Phosphatase Binding Hsp70 Protein Binding Protein Complex Binding Chaperone Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Protein Phosphorylation Mitotic Nuclear Division Cell Proliferation G0 To G1 Transition Cell Division Regulation Of Cell Cycle	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Response To Hypoxia Potassium Ion Transport Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Cell Cycle Arrest Epidermal Growth Factor Receptor Signaling Pathway Sensory Perception Of Sound Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Response To Glucose Positive Regulation Of Cell Death Negative Regulation Of Cell Growth Positive Regulation Of Microtubule Polymerization Response To Estradiol Negative Regulation Of Kinase Activity Fc-epsilon Receptor Signaling Pathway Negative Regulation Of Phosphorylation Response To Drug Negative Regulation Of Apoptotic Process Response To Amino Acid Response To Peptide Hormone Innate Immune Response Positive Regulation Of Protein Catabolic Process Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Mitotic Cell Cycle Response To Cadmium Ion Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Autophagic Cell Death Inner Ear Development Negative Regulation Of Cellular Component Movement Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Cellular Response To Antibiotic Cellular Response To Lithium Ion Cellular Response To Organic Cyclic Compound Mitotic Cell Cycle Arrest
Pathways			Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease Cellular Senescence p53-Dependent G1/S DNA damage checkpoint Cyclin E associated events during G1/S transition AKT phosphorylates targets in the cytosol Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation PI-3K cascade G1/S Transition Removal of licensing factors from origins Switching of origins to a post-replicative state Mitotic G1-G1/S phases Signaling by PDGF DAP12 interactions DNA Damage/Telomere Stress Induced Senescence GAB1 signalosome Senescence-Associated Secretory Phenotype (SASP) S Phase Signaling by ERBB4 Constitutive PI3K/AKT Signaling in Cancer Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by ERBB2 Signaling by EGFR SCF(Skp2)-mediated degradation of p27/p21 Downstream signal transduction Signaling by EGFR in Cancer Fc epsilon receptor (FCERI) signaling Cyclin A:Cdk2-associated events at S phase entry SCF(Skp2)-mediated degradation of p27/p21 PI3K/AKT Signaling in Cancer Adaptive Immune System PIP3 activates AKT signaling Orc1 removal from chromatin p53-Dependent G1 DNA Damage Response PI3K events in ERBB2 signaling Downstream signaling of activated FGFR G1/S DNA Damage Checkpoints Innate Immune System Signalling by NGF Synthesis of DNA G1 Phase Regulation of DNA replication Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Cell Cycle, Mitotic Signaling by FGFR Orc1 removal from chromatin Cyclin D associated events in G1 Cell Cycle Checkpoints
Drugs
Diseases
GWAS			Systemic lupus erythematosus ( 23273568)
Protein-Protein Interactions		18 interactors: APP CABLES1 CABLES2 CCNA2 CCNC CCNE1 CCNE2 CDC37 CDKN1A CDKN1B CDKN3 E2F1 E2F2 E2F3 KIR3DL1 NEDD4L PPARA RB1	62 interactors: ABL1 AKT1 ARHGDIA CAMK1 CASP8 CCNA1 CCNA2 CCNB1 CCND1 CCND2 CCND3 CCNE2 CDC34 CDK2 CDK3 CDK4 CDK5 CKS1B COPS5 CUL1 CUL4A GRB2 HIST1H1A HIST1H1B IRF1 KAT2B KPNA1 KPNA3 KPNA4 KPNA5 KPNA6 LYN MAPK10 MCM7 NUP50 PIN1 PSMB1 RCHY1 RNF123 RPS6KA1 SGK1 SKP1 SKP2 SPDYA SRC STMN1 TRAF2 TSC2 UBAC1 UBB UBE2B UBE2D2 UBE3A UCHL1 XPO1 YES1 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ
Entrez ID		1018	1027
HPRD ID		00446	02867
Ensembl ID		ENSG00000250506	ENSG00000111276
Uniprot IDs		Q00526	P46527 Q6I9V6
PDB IDs		1LFN	1H27 1JSU 2AST
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Cycle Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition G1/S Transition Of Mitotic Cell Cycle Cell Cycle Regulation Of Protein Kinase Activity Mitotic Cell Cycle Regulation Of Kinase Activity Regulation Of Protein Phosphorylation Regulation Of Phosphorylation Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Mitotic Cell Cycle Process Cell Cycle Checkpoint Cell Division Regulation Of Phosphorus Metabolic Process Regulation Of Protein Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Regulation Of Cellular Protein Metabolic Process Cell Cycle Process Regulation Of Mitotic Cell Cycle DNA-templated Transcription, Initiation Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Signal Transduction By P53 Class Mediator Negative Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Regulation Of Catalytic Activity Positive Regulation Of Transcription, DNA-templated Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Lens Fiber Cell Apoptotic Process Notch Signaling Pathway Regulation Of Gene Expression Cell Cycle Arrest Positive Regulation Of Cellular Metabolic Process DNA Damage Checkpoint Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Macromolecule Biosynthetic Process Mitotic Cell Cycle Checkpoint Positive Regulation Of Metabolic Process Positive Regulation Of Gene Expression Signal Transduction Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Intracellular Receptor Signaling Pathway Positive Regulation Of Fibroblast Proliferation Negative Regulation Of Cell Cycle Signaling Negative Regulation Of Mitotic Cell Cycle	Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Protein Metabolic Process G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle Regulation Of Cellular Protein Metabolic Process Cell Cycle Process Mitotic Cell Cycle Mitotic Cell Cycle Process Regulation Of Protein Kinase Activity Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Regulation Of Kinase Activity Regulation Of Protein Phosphorylation Regulation Of Catalytic Activity Positive Regulation Of Cellular Metabolic Process Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Response To Organic Substance Cell Communication Positive Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Cellular Response To Organic Substance Positive Regulation Of Transferase Activity Cellular Response To Stimulus Positive Regulation Of Protein Modification Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Cellular Process Cellular Protein Modification Process Regulation Of Metabolic Process Signal Transduction Positive Regulation Of Cell Cycle Signaling Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Response To Stimulus Protein Catabolic Process Apoptotic Process Regulation Of Intracellular Transport Programmed Cell Death Viral Process G2/M Transition Of Mitotic Cell Cycle Regulation Of Protein Localization Cell Death Death Positive Regulation Of Intracellular Transport Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Organelle Organization
Tagcloud ?		3h adenovirus augmented beta brdu cyclin d2 d3 dedifferentiation exit g0 g1 hypothesized incorporation inducing islets ki67 pancreatic prb quiescence quiescent rat recover regeneration replace staining thymidine transduced tunel	aggregated anaplastic atc braf cdkn2c ctnnb1 eif1ax exclusive exome harbored hypermutator landscape mismatch mlh mlh1 mlh3 msh5 msh6 mutational mutually nf1 nf2 nras ontology pik3ca ret unresponsive ush2a v600e
Tagcloud (Difference) ?		3h adenovirus augmented beta brdu cyclin d2 d3 dedifferentiation exit g0 g1 hypothesized incorporation inducing islets ki67 pancreatic prb quiescence quiescent rat recover regeneration replace staining thymidine transduced tunel	aggregated anaplastic atc braf cdkn2c ctnnb1 eif1ax exclusive exome harbored hypermutator landscape mismatch mlh mlh1 mlh3 msh5 msh6 mutational mutually nf1 nf2 nras ontology pik3ca ret unresponsive ush2a v600e
Tagcloud (Intersection) ?