HERC6 and HERC4

Number of citations of the paper that reports this interaction (PubMedID 18535780)
0

Data Source:
HPRD (in vivo)

		HERC6	HERC4
Description		HECT and RLD domain containing E3 ubiquitin protein ligase family member 6	HECT and RLD domain containing E3 ubiquitin protein ligase 4
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol	Fibrillar Center Cytoplasm Cytosol
	Molecular Function	Ubiquitin-protein Transferase Activity Transferase Activity Ubiquitin Protein Ligase Activity	Ubiquitin-protein Transferase Activity Transferase Activity Ubiquitin Protein Ligase Activity
	Biological Process	Hematopoietic Progenitor Cell Differentiation Ubiquitin-dependent Protein Catabolic Process Response To Bacterium Protein Ubiquitination	Ubiquitin-dependent Protein Catabolic Process Spermatogenesis Protein Ubiquitination Cell Differentiation Negative Regulation Of Smoothened Signaling Pathway
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Lean body mass ( 28552196) Metabolite levels ( 22916037) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Appendicular lean mass ( 33097823) Body mass index ( 28892062)
Interacting Genes		4 interacting genes: HERC3 HERC4 NME2 UBE2L3	7 interacting genes: HERC6 MAFA UBC UBE2D2 UBE2E3 UBE2J2 UBE2L3
Entrez ID		55008	26091
HPRD ID		13647	13646
Ensembl ID		ENSG00000138642	ENSG00000148634
Uniprot IDs		Q8IVU3	Q5GLZ8
PDB IDs		5W87
Enriched GO Terms of Interacting Partners?		Ubiquitin-protein Transferase Activity Transferase Activity Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation ITP Biosynthetic Process Protein Histidine Kinase Activity Post-translational Protein Modification Macromolecule Catabolic Process ITP Metabolic Process Proteolysis UTP Biosynthetic Process GTP Biosynthetic Process UTP Metabolic Process G-quadruplex DNA Binding Ubiquitin-protein Transferase Activator Activity Ubiquitin Protein Ligase Activity Nucleoside Diphosphate Kinase Activity CTP Metabolic Process CTP Biosynthetic Process Protein Modification Process Positive Regulation Of Keratinocyte Differentiation Ubiquitin-like Protein Transferase Activity GTP Metabolic Process Catabolic Process Pyrimidine Ribonucleotide Biosynthetic Process DNA-binding Transcription Activator Activity Positive Regulation Of Epidermal Cell Differentiation Positive Regulation Of Epidermis Development Pyrimidine Nucleotide Biosynthetic Process Positive Regulation Of Protein Targeting To Mitochondrion Ubiquitin Conjugating Enzyme Activity Negative Regulation Of Smoothened Signaling Pathway Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Regulation Of Keratinocyte Differentiation Protein K11-linked Ubiquitination Pyrimidine-containing Compound Biosynthetic Process Regulation Of Protein Targeting To Mitochondrion	Ubiquitin Conjugating Enzyme Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Modification-dependent Protein Catabolic Process Ubiquitin-protein Transferase Activity Proteolysis Involved In Protein Catabolic Process Protein Polyubiquitination Protein Modification Process Macromolecule Catabolic Process Proteolysis Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Protein K11-linked Ubiquitination Protein Metabolic Process Regulation Of Protein Targeting To Mitochondrion Ubiquitin Protein Ligase Binding Transferase Activity Catabolic Process Protein K48-linked Ubiquitination Ubiquitin Ligase Complex ATP Binding Macromolecule Metabolic Process Nucleotide Binding Ubiquitin-protein Transferase Activator Activity Cytosol Protein Tag Activity Positive Regulation Of Establishment Of Protein Localization Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Activity Nucleoplasm
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