HERC6

Description		HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Ubiquitin-protein Transferase Activity Transferase Activity Ubiquitin Protein Ligase Activity
	Biological Process	Hematopoietic Progenitor Cell Differentiation Ubiquitin-dependent Protein Catabolic Process Response To Bacterium Protein Ubiquitination
Pathways		Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Lean body mass ( 28552196) Metabolite levels ( 22916037) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		4 interacting genes: HERC3 HERC4 NME2 UBE2L3
Entrez ID		55008
HPRD ID		13647
Ensembl ID		ENSG00000138642
Uniprot IDs		Q8IVU3
PDB IDs		5W87
Enriched GO Terms of Interacting Partners?		Ubiquitin-protein Transferase Activity Transferase Activity Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation ITP Biosynthetic Process Protein Histidine Kinase Activity Post-translational Protein Modification Macromolecule Catabolic Process ITP Metabolic Process Proteolysis UTP Biosynthetic Process GTP Biosynthetic Process UTP Metabolic Process G-quadruplex DNA Binding Ubiquitin-protein Transferase Activator Activity Ubiquitin Protein Ligase Activity Nucleoside Diphosphate Kinase Activity CTP Metabolic Process CTP Biosynthetic Process Protein Modification Process Positive Regulation Of Keratinocyte Differentiation Ubiquitin-like Protein Transferase Activity GTP Metabolic Process Catabolic Process Pyrimidine Ribonucleotide Biosynthetic Process DNA-binding Transcription Activator Activity Positive Regulation Of Epidermal Cell Differentiation Positive Regulation Of Epidermis Development Pyrimidine Nucleotide Biosynthetic Process Positive Regulation Of Protein Targeting To Mitochondrion Ubiquitin Conjugating Enzyme Activity Negative Regulation Of Smoothened Signaling Pathway Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Regulation Of Keratinocyte Differentiation Protein K11-linked Ubiquitination Pyrimidine-containing Compound Biosynthetic Process Regulation Of Protein Targeting To Mitochondrion
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