HERC6 and NME2

Number of citations of the paper that reports this interaction (PMID 18535780)
6

Data Source:
BioGRID (two hybrid)

		HERC6	NME2
Gene Name		HECT and RLD domain containing E3 ubiquitin protein ligase family member 6	NME/NM23 nucleoside diphosphate kinase 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Ruffle Nucleus Cytoplasm Mitochondrion Centrosome Cytosol Intermediate Filament Focal Adhesion Membrane Lamellipodium Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome Cell Periphery
	Molecular Function	Ubiquitin-protein Transferase Activity Ligase Activity	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Single-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Nucleoside Diphosphate Kinase Activity Protein Histidine Kinase Activity Protein Binding ATP Binding Intermediate Filament Binding Protein Kinase Binding Gamma-tubulin Binding Metal Ion Binding
	Biological Process	Hematopoietic Progenitor Cell Differentiation Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process	Negative Regulation Of Myeloid Leukocyte Differentiation Purine Nucleotide Metabolic Process Nucleoside Diphosphate Phosphorylation GTP Biosynthetic Process Pyrimidine Nucleotide Metabolic Process UTP Biosynthetic Process CTP Biosynthetic Process Transcription, DNA-templated Regulation Of Transcription, DNA-templated Cell Adhesion Integrin-mediated Signaling Pathway Nucleoside Triphosphate Biosynthetic Process Negative Regulation Of Gene Expression Positive Regulation Of Neuron Projection Development Response To Amine Nucleobase-containing Small Molecule Interconversion Peptidyl-histidine Phosphorylation Hippocampus Development Response To Testosterone Cellular Response To Drug Negative Regulation Of Apoptotic Process Small Molecule Metabolic Process Positive Regulation Of Keratinocyte Differentiation Regulation Of Epidermis Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Epithelial Cell Proliferation Response To CAMP Nucleobase-containing Small Molecule Metabolic Process Cellular Response To Glucose Stimulus Cellular Response To Fatty Acid
Pathways			Metabolism of nucleotides Synthesis and interconversion of nucleotide di- and triphosphates
Drugs
Diseases
GWAS		Metabolite levels ( 22916037)	Height ( 20881960)
Protein-Protein Interactions		3 interactors: HERC3 HERC4 NME2	20 interactors: BNIPL CTBP1 DNM1 GIT2 HERC3 HERC5 HERC6 MOB4 NME1 NME1-NME2 NME3 NME4 PPP2CA RAB5A RORA RORB SVIL TBXA2R TERF1 VIM
Entrez ID		55008	4831
HPRD ID		13647	01132
Ensembl ID		ENSG00000138642	ENSG00000243678
Uniprot IDs		Q8IVU3	P22392 Q6FHN3
PDB IDs			1NSK 1NUE 3BBB 3BBC 3BBF
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Peptidyl-histidine Phosphorylation Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Nucleobase-containing Small Molecule Interconversion Protein Modification By Small Protein Conjugation Protein Catabolic Process Positive Regulation Of Keratinocyte Differentiation Cellular Protein Modification Process Positive Regulation Of Epidermal Cell Differentiation Regulation Of Keratinocyte Differentiation GTP Biosynthetic Process UTP Biosynthetic Process Cellular Macromolecule Catabolic Process GTP Metabolic Process UTP Metabolic Process Positive Regulation Of Epidermis Development CTP Biosynthetic Process Nucleoside Diphosphate Phosphorylation Response To Testosterone Pyrimidine Ribonucleotide Biosynthetic Process Regulation Of Epidermal Cell Differentiation Cellular Response To Fatty Acid Pyrimidine Nucleoside Biosynthetic Process Response To Amine Cellular Protein Metabolic Process Negative Regulation Of Myeloid Leukocyte Differentiation Pyrimidine Nucleotide Biosynthetic Process Cellular Response To Drug Nucleotide Phosphorylation Nucleoside Diphosphate Metabolic Process Cellular Response To Glucose Stimulus Regulation Of Epidermis Development Pyrimidine Nucleoside Metabolic Process Response To Fatty Acid Hippocampus Development Positive Regulation Of Epithelial Cell Differentiation Pyrimidine Nucleotide Metabolic Process Cellular Glucose Homeostasis Cellular Response To Carbohydrate Stimulus Nucleoside Triphosphate Biosynthetic Process Negative Regulation Of Myeloid Cell Differentiation Proteolysis Limbic System Development Protein Metabolic Process Regulation Of Myeloid Leukocyte Differentiation Response To CAMP	GTP Biosynthetic Process UTP Biosynthetic Process GTP Metabolic Process UTP Metabolic Process CTP Biosynthetic Process Nucleoside Diphosphate Phosphorylation Pyrimidine Ribonucleotide Biosynthetic Process Pyrimidine Nucleoside Biosynthetic Process Pyrimidine Nucleotide Biosynthetic Process Nucleotide Phosphorylation Nucleoside Diphosphate Metabolic Process Pyrimidine Nucleoside Metabolic Process Pyrimidine Nucleotide Metabolic Process Nucleoside Triphosphate Biosynthetic Process Ribonucleotide Metabolic Process Purine Nucleotide Metabolic Process Ribose Phosphate Metabolic Process Purine Nucleotide Biosynthetic Process Ribose Phosphate Biosynthetic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Purine Nucleoside Metabolic Process Nucleotide Metabolic Process Nucleobase-containing Small Molecule Interconversion Nucleoside Metabolic Process Nucleotide Biosynthetic Process Nucleobase-containing Small Molecule Metabolic Process Negative Regulation Of Cell Differentiation Cellular Macromolecule Catabolic Process Receptor Internalization Thromboxane A2 Signaling Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter By Histone Modification Organophosphate Metabolic Process Regulation Of Cellular Process Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Developmental Process Receptor Metabolic Process Receptor Internalization Involved In Canonical Wnt Signaling Pathway Regulation Of Endosome Size Regulation Of Growth Rate Telomeric Loop Formation Age-dependent Telomere Shortening Negative Regulation Of Chromosome Organization Regulation Of Circadian Rhythm Cerebellar Granule Cell Precursor Proliferation Telomere Maintenance Via Telomere Shortening Steroid Hormone Mediated Signaling Pathway Regulation Of Cellular Component Organization Cell Differentiation Cell Proliferation In Hindbrain Negative Regulation Of Tyrosine Phosphorylation Of Stat3 Protein
Tagcloud ?		al7a1 arhgap1 c25h16orf71 conceptus ddx58 degs endometria ensbtat00000050193 estrus f2rl2 fbxl7 ifi16 ifnt insemination lims2 loc507810 mgc127874 mgc128929 parp12 rnaseq rnf213 samd9 serbp1 srgap2 tbc1d1 wbscr17 znfx1 zswim4 zxfx1	17q12 anonymous brca1 cloning colia1 d17s183 dinucleotide edh17b exclude excludes families heterozygosity hox2 inherited locale ngfr nme1 ovarian phb pinpoint polymorphisms positional q21 rara recombination resolving scg43 thra1 wnt3
Tagcloud (Difference) ?		al7a1 arhgap1 c25h16orf71 conceptus ddx58 degs endometria ensbtat00000050193 estrus f2rl2 fbxl7 ifi16 ifnt insemination lims2 loc507810 mgc127874 mgc128929 parp12 rnaseq rnf213 samd9 serbp1 srgap2 tbc1d1 wbscr17 znfx1 zswim4 zxfx1	17q12 anonymous brca1 cloning colia1 d17s183 dinucleotide edh17b exclude excludes families heterozygosity hox2 inherited locale ngfr nme1 ovarian phb pinpoint polymorphisms positional q21 rara recombination resolving scg43 thra1 wnt3
Tagcloud (Intersection) ?