CIMAP1B and IL2RB

		CIMAP1B	IL2RB
Description		ciliary microtubule associated protein 1B	interleukin 2 receptor subunit beta
Image		No pdb structure
GO Annotations	Cellular Component	Cytoskeleton Cilium Motile Cilium Cell Projection	Endosome Cytosol Plasma Membrane Interleukin-2 Receptor Complex External Side Of Plasma Membrane Cell Surface Membrane
	Molecular Function	Protein Binding	Cytokine Receptor Activity Interleukin-2 Receptor Activity Protein Binding Coreceptor Activity Interleukin-2 Binding Interleukin-15 Receptor Activity
	Biological Process		Signal Transduction Immunoglobulin Mediated Immune Response Cytokine-mediated Signaling Pathway Interleukin-15-mediated Signaling Pathway Interleukin-2-mediated Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of Phagocytosis Protein-containing Complex Assembly
Pathways			RAF/MAP kinase cascade Interleukin-15 signaling Interleukin-15 signaling Interleukin-2 signaling Interleukin receptor SHC signaling
Drugs			Denileukin diftitox Aldesleukin Basiliximab Daclizumab
Diseases
GWAS			Asthma ( 20860503 32296059) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) L-selectin levels ( 25576479) Lack of premeditation ( 30718321) Mean corpuscular volume ( 27863252) Rheumatoid arthritis ( 23143596 24390342) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Tuberculosis ( 24057671) Type 1 diabetes ( 21829393)
Interacting Genes		8 interacting genes: ACTN2 ACTN3 FHL3 HSF2BP KRTAP3-3 MDFI MKRN3 SPTA1	29 interacting genes: CISH EIF3B FYN GRB2 HGS IL15 IL15RA IL2 IL2RA IL2RG JAK1 JAK3 LCK LYN MTDH PIK3R1 PTPN6 RACK1 RAF1 SHB SHC1 SOCS1 SOCS3 STAT1 STAT3 STAT5A STAT5B SYK TRIP13
Entrez ID		440836	3560
HPRD ID		18640	00896
Ensembl ID		ENSG00000177989	ENSG00000100385
Uniprot IDs		A0A8C8KQ56 A1L1A8 A8MYP8 B5MC17 B5MD02	P14784
PDB IDs			2B5I 2ERJ 3QAZ 4GS7 5M5E 6E8K 7S2S
Enriched GO Terms of Interacting Partners?		Cortical Actin Cytoskeleton Actin Filament-based Process Actin Binding Actin Cytoskeleton Organization Z Disc Pseudopodium Focal Adhesion Assembly Actin Filament Binding Cell Junction Cell-substrate Junction Assembly Cell-substrate Junction Organization Structural Constituent Of Muscle Regulation Of Actin Filament Depolymerization Actin Cytoskeleton Sarcomere Actin Filament Uncapping Positive Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Titin Z Domain Binding Muscle Cell Development Cytoskeleton Organization Focal Adhesion Actin Filament Regulation Of Protein Depolymerization Regulation Of The Force Of Skeletal Muscle Contraction Positive Regulation Of Fast-twitch Skeletal Muscle Fiber Contraction Interleukin-2 Receptor Complex Phospholipase C-activating Angiotensin-activated Signaling Pathway Positive Regulation Of Bone Mineralization Involved In Bone Maturation Interleukin-15 Receptor Activity Interleukin-2 Binding Interleukin-2 Receptor Activity Regulation Of Protein-containing Complex Disassembly Microspike Assembly Transmembrane Transporter Binding Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Integrin Binding FATZ Binding Positive Regulation Of Skeletal Muscle Tissue Growth Skeletal Muscle Atrophy Structural Constituent Of Postsynaptic Actin Cytoskeleton Channel Activator Activity Calcium Ion Binding LIM Domain Binding Negative Regulation Of Relaxation Of Muscle Response To Denervation Involved In Regulation Of Muscle Adaptation Transition Between Fast And Slow Fiber Regulation Of Skeletal Muscle Tissue Growth Skeletal Muscle Adaptation Striated Muscle Atrophy	Cytokine-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Hemopoiesis Lymphocyte Activation Regulation Of Multicellular Organismal Development Interleukin-15-mediated Signaling Pathway Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Lymphocyte Activation Positive Regulation Of T Cell Activation Leukocyte Activation Regulation Of Developmental Process Positive Regulation Of Leukocyte Cell-cell Adhesion Interleukin-2-mediated Signaling Pathway Regulation Of Lymphocyte Differentiation Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Cell Activation Regulation Of Cell-cell Adhesion Cell Surface Receptor Signaling Pathway Via STAT Regulation Of Lymphocyte Activation Cell Activation Positive Regulation Of Lymphocyte Differentiation Interleukin-9-mediated Signaling Pathway Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Adhesion Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Cell Activation Positive Regulation Of Developmental Process Regulation Of Cell Adhesion Cell Differentiation Mononuclear Cell Differentiation Regulation Of Cell Development Growth Hormone Receptor Signaling Pathway Phosphotyrosine Residue Binding Regulation Of T Cell Differentiation Positive Regulation Of Leukocyte Differentiation Leukocyte Differentiation Regulation Of Multicellular Organismal Process T Cell Activation Growth Hormone Receptor Signaling Pathway Via JAK-STAT Signal Transduction Lymphocyte Differentiation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Lymphocyte Proliferation Cellular Developmental Process Mononuclear Cell Proliferation Positive Regulation Of T Cell Differentiation Interleukin-7-mediated Signaling Pathway Regulation Of Cell Differentiation Activated T Cell Proliferation
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