IVD

Description		isovaleryl-CoA dehydrogenase
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GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Matrix
	Molecular Function	Acyl-CoA Dehydrogenase Activity Protein Binding 3-methylbutanoyl-CoA Dehydrogenase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-CH Group Of Donors Short-chain Fatty Acyl-CoA Dehydrogenase Activity Identical Protein Binding Flavin Adenine Dinucleotide Binding
	Biological Process	L-leucine Catabolic Process Lipid Metabolic Process Fatty Acid Metabolic Process Branched-chain Amino Acid Catabolic Process Fatty Acid Beta-oxidation Using Acyl-CoA Dehydrogenase
Pathways		Branched-chain amino acid catabolism Isovaleric acidemia
Drugs		Flavin adenine dinucleotide Coenzyme A persulfide
Diseases		Isovaleric acidemia (IVA)
GWAS		Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) FEV1 ( 30804560) Idiopathic pulmonary fibrosis ( 31710517) Intelligence (MTAG) ( 29326435) Lung function (FVC) ( 30804560) Malaria ( 31844061) Metabolic traits ( 21886157) Serum metabolite levels ( 33031748)
Interacting Genes		4 interacting genes: ACTN3 GPSM3 MGAT5B PNMA1
Entrez ID		3712
HPRD ID		09516
Ensembl ID		ENSG00000128928
Uniprot IDs		A0A0A0MT83 A0A0S2Z4K7 P26440
PDB IDs		1IVH 8SGR
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Regulation Of The Force Of Skeletal Muscle Contraction Positive Regulation Of Fast-twitch Skeletal Muscle Fiber Contraction Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase Activity Negative Regulation Of Relaxation Of Muscle Response To Muscle Inactivity Response To Denervation Involved In Regulation Of Muscle Adaptation Positive Regulation Of Skeletal Muscle Tissue Growth Positive Regulation Of Skeletal Muscle Fiber Development Positive Regulation Of Bone Mineralization Involved In Bone Maturation Transition Between Fast And Slow Fiber Regulation Of Skeletal Muscle Tissue Growth Skeletal Muscle Atrophy Skeletal Muscle Adaptation Striated Muscle Atrophy Negative Regulation Of Oxidative Phosphorylation Muscle Atrophy Negative Regulation Of Cellular Respiration Regulation Of Skeletal Muscle Fiber Development Regulation Of Skeletal Muscle Adaptation Response To Inactivity Positive Regulation Of Striated Muscle Contraction Negative Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Relaxation Of Muscle Positive Regulation Of Striated Muscle Tissue Development Negative Regulation Of Glycolytic Process Negative Regulation Of Calcium-mediated Signaling Regulation Of Skeletal Muscle Contraction Positive Regulation Of Skeletal Muscle Tissue Development Regulation Of Oxidative Phosphorylation Pseudopodium Regulation Of Skeletal Muscle Tissue Development Negative Regulation Of ATP Metabolic Process Regulation Of Aerobic Respiration Focal Adhesion Assembly GTPase Regulator Activity Bone Morphogenesis Inflammatory Response To Antigenic Stimulus Positive Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Calcineurin-mediated Signaling Cell-substrate Junction Assembly Structural Constituent Of Muscle Regulation Of Striated Muscle Tissue Development Cell-substrate Junction Organization Regulation Of Cellular Respiration Positive Regulation Of Bone Mineralization Positive Regulation Of Striated Muscle Cell Differentiation Regulation Of Muscle Organ Development Regulation Of Myotube Differentiation
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