EIF2S2 and APLP1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		EIF2S2	APLP1
Gene Name		eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa	amyloid beta (A4) precursor-like protein 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Eukaryotic Translation Initiation Factor 2 Complex	Basement Membrane Golgi Apparatus Plasma Membrane Integral Component Of Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Binding Translation Initiation Factor Activity Protein Binding Translation Factor Activity, Nucleic Acid Binding Poly(A) RNA Binding Metal Ion Binding	Protein Binding Heparin Binding Alpha-2A Adrenergic Receptor Binding Alpha-2B Adrenergic Receptor Binding Alpha-2C Adrenergic Receptor Binding Identical Protein Binding Transition Metal Ion Binding
	Biological Process	In Utero Embryonic Development Male Germ Cell Proliferation Translation Translational Initiation Male Gonad Development Gene Expression Cellular Protein Metabolic Process	MRNA Polyadenylation Regulation Of Translation Endocytosis Apoptotic Process Cell Adhesion Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Nervous System Development Organ Morphogenesis Extracellular Matrix Organization Negative Regulation Of CAMP Biosynthetic Process Forebrain Development Cellular Response To Norepinephrine Stimulus
Pathways		Ribosomal scanning and start codon recognition Recycling of eIF2:GDP Translation initiation complex formation Formation of the ternary complex, and subsequently, the 43S complex GTP hydrolysis and joining of the 60S ribosomal subunit Translation Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Cap-dependent Translation Initiation L13a-mediated translational silencing of Ceruloplasmin expression
Drugs
Diseases
GWAS		Breast cancer ( 22976474)
Protein-Protein Interactions		22 interactors: APLP1 APP CCDC90B CRMP1 CSNK2A1 CSNK2B EIF2B1 EIF2B3 EIF2B4 EIF2B5 EIF2S1 EIF4G2 EIF5 HMGA1 KIAA1377 NCK1 PLEKHM1 PRKDC TLE1 TP53 UNC119 ZBTB16	43 interactors: ANXA7 APBB1 APBB3 CDK4 CDKN1A CDKN2C CRCT1 CSNK2B DAB1 DAB2 EEF1A1 EIF2S2 GDF9 GSTM4 HAP1 HLA-DQA1 HSPE1 ING5 KAT5 LRIF1 MPHOSPH6 NACA PCDHA4 PHF10 PIN1 PNP PRNP RAP1B RBM48 RCC1 SAT1 SETDB1 SMN1 SNCA STX5 TCF21 TK1 TMSB4X TOE1 TSC22D1 UTP14A VIM ZNF24
Entrez ID		8894	333
HPRD ID		04882	00102
Ensembl ID		ENSG00000125977	ENSG00000105290
Uniprot IDs		P20042 Q6IBR8	F5GZ08 P51693
PDB IDs			3PMR 3Q7G 3Q7L 3QMK
Enriched GO Terms of Interacting Partners?		Regulation Of Translation In Response To Stress Regulation Of Translational Initiation Regulation Of Translation Posttranscriptional Regulation Of Gene Expression Regulation Of Translational Initiation In Response To Stress Negative Regulation Of Translational Initiation In Response To Stress Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Translation In Response To Stress Translational Initiation Negative Regulation Of Translational Initiation Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Nervous System Development Oligodendrocyte Development Central Nervous System Development Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression Gene Expression Cell Development Negative Regulation Of Cellular Protein Metabolic Process Developmental Process Regulation Of Metabolic Process Neurogenesis Negative Regulation Of Protein Metabolic Process Cellular Response To Stimulus Oligodendrocyte Differentiation Anatomical Structure Development Negative Regulation Of Gene Expression System Development Negative Regulation Of Translation Translation Regulation Of Catalytic Activity Anatomical Structure Morphogenesis Response To Stimulus Glial Cell Development Response To Abiotic Stimulus Cellular Response To Stress Response To Heat Multicellular Organismal Development Response To Glucose Positive Regulation Of Protein Metabolic Process Cell Differentiation Rhythmic Process Positive Regulation Of Cell Aging Cellular Macromolecule Biosynthetic Process Cellular Protein Metabolic Process Response To Endoplasmic Reticulum Stress Macromolecule Biosynthetic Process B Cell Lineage Commitment	Developmental Process Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Cellular Component Organization Anatomical Structure Development Positive Regulation Of Protein Metabolic Process System Development Positive Regulation Of Metabolic Process Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Pathway-restricted SMAD Protein Phosphorylation Multicellular Organismal Development Regulation Of Phosphorylation Response To Organic Substance Regulation Of Gene Expression Response To Copper Ion Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Modification Process Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Regulation Of Cellular Process Regulation Of Cell Proliferation Positive Regulation Of Protein Phosphorylation Cellular Aromatic Compound Metabolic Process Regulation Of Protein Kinase Activity Regulation Of Cell Death Regulation Of Kinase Activity Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Response To Copper Ion Cellular Response To Growth Factor Stimulus Positive Regulation Of Programmed Cell Death Negative Regulation Of Growth Response To Growth Factor Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Growth Positive Regulation Of Cell Death Positive Regulation Of Phosphorylation Heterocycle Metabolic Process Response To Organic Cyclic Compound Digestive Tract Development Negative Regulation Of Cellular Metabolic Process Cell Cycle Arrest RNA Metabolic Process Response To Inorganic Substance Regulation Of Cell Cycle Digestive System Development Negative Regulation Of Cell Growth G1/S Transition Of Mitotic Cell Cycle
Tagcloud ?		biosynthetic cd47 cycs dataset dj e2f6 encyclopedia extra fmr1 fxr2 gpr37 logical mapt nrf1 paelr park2 park6 park7 parkin pen2 perturbation pink1 psenen retrieved seq stringent tomm34 unrecognized	abundance allocated analyzing aplp2 app apparatus appsalpha attached compartments corresponds endosomal golgi homozygous immunopurification impacts knockout ko organellar pool presynaptic residing sv2 sv2a synaptic synaptogamin synaptophysin synaptotagmin vesicle zone
Tagcloud (Difference) ?		biosynthetic cd47 cycs dataset dj e2f6 encyclopedia extra fmr1 fxr2 gpr37 logical mapt nrf1 paelr park2 park6 park7 parkin pen2 perturbation pink1 psenen retrieved seq stringent tomm34 unrecognized	abundance allocated analyzing aplp2 app apparatus appsalpha attached compartments corresponds endosomal golgi homozygous immunopurification impacts knockout ko organellar pool presynaptic residing sv2 sv2a synaptic synaptogamin synaptophysin synaptotagmin vesicle zone
Tagcloud (Intersection) ?