EIF2S2 and EIF2B4

Number of citations of the paper that reports this interaction (PubMedID 9446619)
0

Data Source:
HPRD (in vitro)

		EIF2S2	EIF2B4
Description		eukaryotic translation initiation factor 2 subunit beta	eukaryotic translation initiation factor 2B subunit delta
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 2 Complex Synapse	Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 2B Complex
	Molecular Function	RNA Binding MRNA Binding Translation Initiation Factor Activity Protein Binding Translation Factor Activity, RNA Binding Zinc Ion Binding Translation Initiation Factor Binding Metal Ion Binding	Translation Initiation Factor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Translation Initiation Factor Binding
	Biological Process	In Utero Embryonic Development Formation Of Translation Preinitiation Complex Male Germ Cell Proliferation Cytoplasmic Translational Initiation Translation Translational Initiation Male Gonad Development	Ovarian Follicle Development Cytoplasmic Translational Initiation Translation Translational Initiation Regulation Of Translation Central Nervous System Development Response To Heat Response To Glucose Oligodendrocyte Development Myelination Response To Peptide Hormone Animal Organ Development T Cell Receptor Signaling Pathway
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression PERK regulates gene expression PERK regulates gene expression ABC-family proteins mediated transport Translation initiation complex formation Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Recycling of eIF2:GDP Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK1 (HRI) to heme deficiency PKR-mediated signaling Cellular response to mitochondrial stress	Recycling of eIF2:GDP
Drugs
Diseases			Leukoencephalopathy with vanishing white matter; Vanishing white matter disease; Childhood ataxia with diffuse central nervous system hypomyelination (CACH); Cree leukoencephalopathy (CLE)
GWAS		Breast cancer ( 22976474) Estimated glomerular filtration rate in non-diabetics ( 31451708) Refractive error ( 32231278) Skin pigmentation ( 28300201) Type 2 diabetes ( 30054458)	Non-oily fish consumption ( 32066663)
Interacting Genes		25 interacting genes: APLP1 APP CCDC90B CEBPA CEP126 CRMP1 CSNK2A1 CSNK2B EIF2B1 EIF2B3 EIF2B4 EIF2B5 EIF2S1 EIF4G2 EIF5 ESR1 HMGA1 NCK1 OGT PLEKHM1 PRKDC TLE1 TP53 UNC119 ZBTB16	3 interacting genes: EIF2B2 EIF2S1 EIF2S2
Entrez ID		8894	8890
HPRD ID		04882	09459
Ensembl ID		ENSG00000125977	ENSG00000115211
Uniprot IDs		P20042 Q6IBR8	B4DUP5 E7ERK9 F8W8L6 Q71US4 Q9HBP7 Q9UI10
PDB IDs		6K71 6K72 6YBV 6ZMW 6ZP4 7A09 7D43 7QP6 8OZ0 8PJ1 8PPL	6CAJ 6EZO 6K71 6K72 6O81 6O85 6O9Z 7D43 7D44 7D45 7D46 7F64 7F66 7F67 7KMF 7L70 7L7G 7RLO 7TRJ 7VLK 8TQO 8TQZ
Enriched GO Terms of Interacting Partners?		Translation Initiation Factor Activity Regulation Of Translation Eukaryotic Translation Initiation Factor 2B Complex Translational Initiation Regulation Of Translational Initiation Post-transcriptional Regulation Of Gene Expression Regulation Of Protein Metabolic Process Glial Cell Development Translation Oligodendrocyte Development Central Nervous System Development Cytoplasmic Translational Initiation Response To Heat T Cell Receptor Signaling Pathway Regulation Of Programmed Cell Death Response To Glucose Signal Transduction Transcription Regulator Complex Cytosol Response To Monosaccharide Cell Surface Receptor Signaling Pathway Response To Hormone Response To Temperature Stimulus Antigen Receptor-mediated Signaling Pathway Response To Carbohydrate Protein-containing Complex Organization Cell Development Regulation Of Apoptotic Process Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Eukaryotic Initiation Factor EIF2 Binding Macromolecule Biosynthetic Process Response To Peptide Hormone Molecular Function Activator Activity Cell Death Cellular Response To Norepinephrine Stimulus Macromolecule Metabolic Process Response To Norepinephrine Protein-containing Complex Assembly Regulation Of Primary Metabolic Process Positive Regulation Of Apoptotic Process Immune Response-activating Signaling Pathway Positive Regulation Of Immune System Process Positive Regulation Of Programmed Cell Death Regulation Of Proteolysis Protein Domain Specific Binding PML Body Positive Regulation Of Protein Metabolic Process Negative Regulation Of Metabolic Process B Cell Lineage Commitment	Translation Initiation Factor Activity Translational Initiation Eukaryotic Translation Initiation Factor 2 Complex Translation Cytoplasmic Translational Initiation Response To Heat Regulation Of Translational Initiation Translation Initiation Ternary Complex Response To Temperature Stimulus Response To Manganese-induced Endoplasmic Reticulum Stress Glial Limiting End-foot Male Germ Cell Proliferation Macromolecule Biosynthetic Process Response To Kainic Acid Negative Regulation Of Translational Initiation In Response To Stress Positive Regulation Of Type B Pancreatic Cell Apoptotic Process Eukaryotic Translation Initiation Factor 2B Complex HRI-mediated Signaling Regulation Of Translation In Response To Endoplasmic Reticulum Stress Mitochondrial Respirasome Assembly Regulation Of Translational Initiation In Response To Stress Regulation Of Translation Cellular Response To Manganese Ion Formation Of Translation Preinitiation Complex PERK-mediated Unfolded Protein Response Response To Manganese Ion Eukaryotic 48S Preinitiation Complex Post-transcriptional Regulation Of Gene Expression Positive Regulation Of Epithelial Cell Apoptotic Process Regulation Of Translation In Response To Stress Translation Factor Activity, RNA Binding Translation Initiation Factor Binding Oligodendrocyte Development Protein Metabolic Process Stress Granule Assembly ER-nucleus Signaling Pathway Integrated Stress Response Signaling Negative Regulation Of Translational Initiation Ovarian Follicle Development Synapse Cellular Response To Heat Regulation Of Epithelial Cell Apoptotic Process Mitophagy Cellular Response To Amino Acid Starvation Response To Amino Acid Starvation Endoplasmic Reticulum Unfolded Protein Response Glial Cell Development Autophagy Of Mitochondrion Ribosome Binding
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