EIF2S2 and EIF2B4

Number of citations of the paper that reports this interaction (PMID 9446619)
17

Data Source:
HPRD (in vitro)

		EIF2S2	EIF2B4
Gene Name		eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa	eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Eukaryotic Translation Initiation Factor 2 Complex	Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 2B Complex
	Molecular Function	RNA Binding Translation Initiation Factor Activity Protein Binding Translation Factor Activity, Nucleic Acid Binding Poly(A) RNA Binding Metal Ion Binding	Translation Initiation Factor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Translation Initiation Factor Binding S-methyl-5-thioribose-1-phosphate Isomerase Activity
	Biological Process	In Utero Embryonic Development Male Germ Cell Proliferation Translation Translational Initiation Male Gonad Development Gene Expression Cellular Protein Metabolic Process	Ovarian Follicle Development Translation Translational Initiation Regulation Of Translation Regulation Of Translational Initiation Response To Heat Response To Glucose Gene Expression Oligodendrocyte Development L-methionine Biosynthetic Process From Methylthioadenosine Negative Regulation Of Translational Initiation In Response To Stress Myelination Response To Peptide Hormone Positive Regulation Of GTPase Activity Cellular Protein Metabolic Process Negative Regulation Of Translational Initiation Cellular Response To Stimulus
Pathways		Ribosomal scanning and start codon recognition Recycling of eIF2:GDP Translation initiation complex formation Formation of the ternary complex, and subsequently, the 43S complex GTP hydrolysis and joining of the 60S ribosomal subunit Translation Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Cap-dependent Translation Initiation L13a-mediated translational silencing of Ceruloplasmin expression	Recycling of eIF2:GDP Translation Eukaryotic Translation Initiation Cap-dependent Translation Initiation
Drugs
Diseases
GWAS		Breast cancer ( 22976474)
Protein-Protein Interactions		22 interactors: APLP1 APP CCDC90B CRMP1 CSNK2A1 CSNK2B EIF2B1 EIF2B3 EIF2B4 EIF2B5 EIF2S1 EIF4G2 EIF5 HMGA1 KIAA1377 NCK1 PLEKHM1 PRKDC TLE1 TP53 UNC119 ZBTB16	4 interactors: EIF2B2 EIF2B5 EIF2S1 EIF2S2
Entrez ID		8894	8890
HPRD ID		04882	09459
Ensembl ID		ENSG00000125977	ENSG00000115211
Uniprot IDs		P20042 Q6IBR8	Q9UI10
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Translation In Response To Stress Regulation Of Translational Initiation Regulation Of Translation Posttranscriptional Regulation Of Gene Expression Regulation Of Translational Initiation In Response To Stress Negative Regulation Of Translational Initiation In Response To Stress Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Translation In Response To Stress Translational Initiation Negative Regulation Of Translational Initiation Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Nervous System Development Oligodendrocyte Development Central Nervous System Development Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression Gene Expression Cell Development Negative Regulation Of Cellular Protein Metabolic Process Developmental Process Regulation Of Metabolic Process Neurogenesis Negative Regulation Of Protein Metabolic Process Cellular Response To Stimulus Oligodendrocyte Differentiation Anatomical Structure Development Negative Regulation Of Gene Expression System Development Negative Regulation Of Translation Translation Regulation Of Catalytic Activity Anatomical Structure Morphogenesis Response To Stimulus Glial Cell Development Response To Abiotic Stimulus Cellular Response To Stress Response To Heat Multicellular Organismal Development Response To Glucose Positive Regulation Of Protein Metabolic Process Cell Differentiation Rhythmic Process Positive Regulation Of Cell Aging Cellular Macromolecule Biosynthetic Process Cellular Protein Metabolic Process Response To Endoplasmic Reticulum Stress Macromolecule Biosynthetic Process B Cell Lineage Commitment	Translational Initiation Regulation Of Translational Initiation Translation Regulation Of Translational Initiation In Response To Stress Regulation Of Translation In Response To Stress Gonad Development Development Of Primary Sexual Characteristics Regulation Of Translation Sex Differentiation Oligodendrocyte Development Posttranscriptional Regulation Of Gene Expression Reproductive Structure Development Reproductive System Development Ovarian Follicle Development Oligodendrocyte Differentiation Ovulation Cycle Process Developmental Process Involved In Reproduction Glial Cell Development Female Gonad Development Response To Heat Ovulation Cycle Development Of Primary Female Sexual Characteristics Multicellular Organismal Reproductive Process Multicellular Organism Reproduction Response To Glucose Myelination Axon Ensheathment Response To Endoplasmic Reticulum Stress Positive Regulation Of Hydrolase Activity Reproduction Glial Cell Differentiation Response To Carbohydrate Response To Temperature Stimulus Gene Expression Single Organism Reproductive Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Gliogenesis Male Germ Cell Proliferation Reproductive Process Negative Regulation Of Translational Initiation In Response To Stress Rhythmic Process Positive Regulation Of Catalytic Activity Cellular Protein Metabolic Process Negative Regulation Of Translation In Response To Stress Biosynthetic Process Response To Peptide Hormone Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Translational Initiation Response To Peptide
Tagcloud ?		biosynthetic cd47 cycs dataset dj e2f6 encyclopedia extra fmr1 fxr2 gpr37 logical mapt nrf1 paelr park2 park6 park7 parkin pen2 perturbation pink1 psenen retrieved seq stringent tomm34 unrecognized	1090c 1980s 314a 318a 877c ataxia atrophy compiled deterioration dystonic genetics hemiparesis hereditary leukoencephalopathy list macrocephaly manifestation matter movements necropsy optic spain spasticity suffered vanishing vwm
Tagcloud (Difference) ?		biosynthetic cd47 cycs dataset dj e2f6 encyclopedia extra fmr1 fxr2 gpr37 logical mapt nrf1 paelr park2 park6 park7 parkin pen2 perturbation pink1 psenen retrieved seq stringent tomm34 unrecognized	1090c 1980s 314a 318a 877c ataxia atrophy compiled deterioration dystonic genetics hemiparesis hereditary leukoencephalopathy list macrocephaly manifestation matter movements necropsy optic spain spasticity suffered vanishing vwm
Tagcloud (Intersection) ?