EIF2S2 and EIF4G2

Number of citations of the paper that reports this interaction (PMID 16932749)
21

Data Source:
HPRD (in vitro, in vivo)

		EIF2S2	EIF4G2
Gene Name		eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa	eukaryotic translation initiation factor 4 gamma, 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Eukaryotic Translation Initiation Factor 2 Complex	Cytosol Membrane Eukaryotic Translation Initiation Factor 4F Complex
	Molecular Function	RNA Binding Translation Initiation Factor Activity Protein Binding Translation Factor Activity, Nucleic Acid Binding Poly(A) RNA Binding Metal Ion Binding	Translation Initiation Factor Activity Protein Binding Translation Factor Activity, Nucleic Acid Binding Poly(A) RNA Binding
	Biological Process	In Utero Embryonic Development Male Germ Cell Proliferation Translation Translational Initiation Male Gonad Development Gene Expression Cellular Protein Metabolic Process	Translational Initiation Regulation Of Translational Initiation Cell Cycle Arrest Cell Death Cytokine-mediated Signaling Pathway
Pathways		Ribosomal scanning and start codon recognition Recycling of eIF2:GDP Translation initiation complex formation Formation of the ternary complex, and subsequently, the 43S complex GTP hydrolysis and joining of the 60S ribosomal subunit Translation Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Cap-dependent Translation Initiation L13a-mediated translational silencing of Ceruloplasmin expression	ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system Antiviral mechanism by IFN-stimulated genes
Drugs
Diseases
GWAS		Breast cancer ( 22976474)
Protein-Protein Interactions		22 interactors: APLP1 APP CCDC90B CRMP1 CSNK2A1 CSNK2B EIF2B1 EIF2B3 EIF2B4 EIF2B5 EIF2S1 EIF4G2 EIF5 HMGA1 KIAA1377 NCK1 PLEKHM1 PRKDC TLE1 TP53 UNC119 ZBTB16	11 interactors: CASP3 EIF2S2 EIF3A EIF4A1 EIF4A2 EIF4E EIF5 MKNK1 NCBP1 RPA2 SKIL
Entrez ID		8894	1982
HPRD ID		04882	09084
Ensembl ID		ENSG00000125977	ENSG00000110321
Uniprot IDs		P20042 Q6IBR8	P78344 Q2TU89
PDB IDs			3D3M 3L6A 4IUL
Enriched GO Terms of Interacting Partners?		Regulation Of Translation In Response To Stress Regulation Of Translational Initiation Regulation Of Translation Posttranscriptional Regulation Of Gene Expression Regulation Of Translational Initiation In Response To Stress Negative Regulation Of Translational Initiation In Response To Stress Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Translation In Response To Stress Translational Initiation Negative Regulation Of Translational Initiation Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Nervous System Development Oligodendrocyte Development Central Nervous System Development Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression Gene Expression Cell Development Negative Regulation Of Cellular Protein Metabolic Process Developmental Process Regulation Of Metabolic Process Neurogenesis Negative Regulation Of Protein Metabolic Process Cellular Response To Stimulus Oligodendrocyte Differentiation Anatomical Structure Development Negative Regulation Of Gene Expression System Development Negative Regulation Of Translation Translation Regulation Of Catalytic Activity Anatomical Structure Morphogenesis Response To Stimulus Glial Cell Development Response To Abiotic Stimulus Cellular Response To Stress Response To Heat Multicellular Organismal Development Response To Glucose Positive Regulation Of Protein Metabolic Process Cell Differentiation Rhythmic Process Positive Regulation Of Cell Aging Cellular Macromolecule Biosynthetic Process Cellular Protein Metabolic Process Response To Endoplasmic Reticulum Stress Macromolecule Biosynthetic Process B Cell Lineage Commitment	Regulation Of Translational Initiation Translational Initiation Regulation Of Translation Aromatic Compound Catabolic Process Posttranscriptional Regulation Of Gene Expression MRNA 3'-end Processing RNA 3'-end Processing Nuclear-transcribed MRNA Poly(A) Tail Shortening Translation Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process Cellular Macromolecule Catabolic Process RNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Response To Cytokine Regulation Of Protein Metabolic Process Nuclear Export Gene Expression Biosynthetic Process MRNA Processing Catabolic Process MRNA Metabolic Process Cellular Response To Organic Substance Viral Process Cellular Metabolic Process RNA Processing Nucleocytoplasmic Transport Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Nuclear Transport Response To Organic Substance MRNA Export From Nucleus Lymphocyte Homeostasis Negative Regulation Of RNA-directed RNA Polymerase Activity RNA Export From Nucleus Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cell Cycle Protein Metabolic Process Leukocyte Homeostasis Regulation Of Metabolic Process Negative Regulation Of Cell Cycle Cytokine-mediated Signaling Pathway Extrinsic Apoptotic Signaling Pathway Cellular Protein Metabolic Process Cell Surface Receptor Signaling Pathway MRNA Transport Nucleobase-containing Compound Metabolic Process Regulation Of Response To DNA Damage Stimulus
Tagcloud ?		biosynthetic cd47 cycs dataset dj e2f6 encyclopedia extra fmr1 fxr2 gpr37 logical mapt nrf1 paelr park2 park6 park7 parkin pen2 perturbation pink1 psenen retrieved seq stringent tomm34 unrecognized	11p15 4f backcross blot casein codes conserved contains copy exhibits frame germ glycosylation homology interspecific iso northern p82 polypeptide reading segment similarity southern syntenic ubiquitously vertebrates wheat zoo
Tagcloud (Difference) ?		biosynthetic cd47 cycs dataset dj e2f6 encyclopedia extra fmr1 fxr2 gpr37 logical mapt nrf1 paelr park2 park6 park7 parkin pen2 perturbation pink1 psenen retrieved seq stringent tomm34 unrecognized	11p15 4f backcross blot casein codes conserved contains copy exhibits frame germ glycosylation homology interspecific iso northern p82 polypeptide reading segment similarity southern syntenic ubiquitously vertebrates wheat zoo
Tagcloud (Intersection) ?