EIF2S2 and PLEKHM1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		EIF2S2	PLEKHM1
Description		eukaryotic translation initiation factor 2 subunit beta	pleckstrin homology and RUN domain containing M1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 2 Complex Synapse	Nucleoplasm Nucleolus Lysosome Lysosomal Membrane Endosome Endosome Membrane Membrane Cytoplasmic Vesicle Late Endosome Membrane Autolysosome Autolysosome Membrane
	Molecular Function	RNA Binding MRNA Binding Translation Initiation Factor Activity Protein Binding Translation Factor Activity, RNA Binding Zinc Ion Binding Translation Initiation Factor Binding Metal Ion Binding	Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	In Utero Embryonic Development Formation Of Translation Preinitiation Complex Male Germ Cell Proliferation Cytoplasmic Translational Initiation Translation Translational Initiation Male Gonad Development	Autophagy Protein Transport Lysosome Localization Positive Regulation Of Bone Resorption Autophagosome-lysosome Fusion Positive Regulation Of Ruffle Assembly Late Endosome To Lysosome Transport
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression PERK regulates gene expression PERK regulates gene expression ABC-family proteins mediated transport Translation initiation complex formation Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Recycling of eIF2:GDP Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK1 (HRI) to heme deficiency PKR-mediated signaling Cellular response to mitochondrial stress
Drugs
Diseases
GWAS		Breast cancer ( 22976474) Estimated glomerular filtration rate in non-diabetics ( 31451708) Refractive error ( 32231278) Skin pigmentation ( 28300201) Type 2 diabetes ( 30054458)	Alcohol use disorder (total score) ( 30336701) Brain morphology (MOSTest) ( 32665545) Cognitive function ( 28093568) Cortical volume ( 32963231) Daytime nap ( 33568662) Epithelial ovarian cancer ( 25581431) Hip circumference ( 28552196) Liver enzyme levels (alkaline phosphatase) ( 33972514) Male-pattern baldness ( 28196072 29146897) Monocyte count ( 32888494) Neuroticism ( 29255261) Parkinson's disease ( 20070850) Remission after SSRI treatment in MDD or neuroticism ( 29559929)
Interacting Genes		25 interacting genes: APLP1 APP CCDC90B CEBPA CEP126 CRMP1 CSNK2A1 CSNK2B EIF2B1 EIF2B3 EIF2B4 EIF2B5 EIF2S1 EIF4G2 EIF5 ESR1 HMGA1 NCK1 OGT PLEKHM1 PRKDC TLE1 TP53 UNC119 ZBTB16	14 interacting genes: BID CTDSP1 EIF2S2 GADD45G MAP1LC3B MAPK1 MAPK6 MOB4 MTOR MUC2 PAFAH1B3 SERPINB9 TRIM54 VPS18
Entrez ID		8894	9842
HPRD ID		04882	11439
Ensembl ID		ENSG00000125977	ENSG00000225190
Uniprot IDs		P20042 Q6IBR8	A0A8V8TPW0 Q9Y4G2
PDB IDs		6K71 6K72 6YBV 6ZMW 6ZP4 7A09 7D43 7QP6 8OZ0 8PJ1 8PPL	5DPR 5DPS 5DPT 5DPW 8JC5
Enriched GO Terms of Interacting Partners?		Translation Initiation Factor Activity Regulation Of Translation Eukaryotic Translation Initiation Factor 2B Complex Translational Initiation Regulation Of Translational Initiation Post-transcriptional Regulation Of Gene Expression Regulation Of Protein Metabolic Process Glial Cell Development Translation Oligodendrocyte Development Central Nervous System Development Cytoplasmic Translational Initiation Response To Heat T Cell Receptor Signaling Pathway Regulation Of Programmed Cell Death Response To Glucose Signal Transduction Transcription Regulator Complex Cytosol Response To Monosaccharide Cell Surface Receptor Signaling Pathway Response To Hormone Response To Temperature Stimulus Antigen Receptor-mediated Signaling Pathway Response To Carbohydrate Protein-containing Complex Organization Cell Development Regulation Of Apoptotic Process Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Eukaryotic Initiation Factor EIF2 Binding Macromolecule Biosynthetic Process Response To Peptide Hormone Molecular Function Activator Activity Cell Death Cellular Response To Norepinephrine Stimulus Macromolecule Metabolic Process Response To Norepinephrine Protein-containing Complex Assembly Regulation Of Primary Metabolic Process Positive Regulation Of Apoptotic Process Immune Response-activating Signaling Pathway Positive Regulation Of Immune System Process Positive Regulation Of Programmed Cell Death Regulation Of Proteolysis Protein Domain Specific Binding PML Body Positive Regulation Of Protein Metabolic Process Negative Regulation Of Metabolic Process B Cell Lineage Commitment
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