LDB1 and LHX2

Number of citations of the paper that reports this interaction (PMID 20211142)
148

Data Source:
BioGRID (two hybrid)

		LDB1	LHX2
Gene Name		LIM domain binding 1	LIM homeobox 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Nucleus Transcription Factor Complex Protein Complex	Nucleus
	Molecular Function	RNA Polymerase II Activating Transcription Factor Binding Enhancer Sequence-specific DNA Binding Chromatin Binding Transcription Corepressor Activity Enzyme Binding LIM Domain Binding Protein Homodimerization Activity Protein Self-association	RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Chromatin Binding Zinc Ion Binding Sequence-specific DNA Binding
	Biological Process	Transcription-dependent Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery Gastrulation With Mouth Forming Second Hair Follicle Development Transcription, DNA-templated Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Multicellular Organismal Development Anterior/posterior Axis Specification Epithelial Structure Maintenance Wnt Signaling Pathway Cerebellar Purkinje Cell Differentiation Cellular Component Assembly Neuron Differentiation Regulation Of DNA-templated Transcription, Elongation Somatic Stem Cell Maintenance Histone H3-K4 Acetylation Negative Regulation Of Erythrocyte Differentiation Positive Regulation Of Cell Adhesion Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Hemoglobin Biosynthetic Process	Neural Tube Closure Transcription From RNA Polymerase II Promoter Axon Guidance Mesoderm Development Dorsal/ventral Pattern Formation Olfactory Bulb Development Telencephalon Regionalization Cerebral Cortex Development Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Axon Extension Retina Development In Camera-type Eye Negative Regulation Of Transcription Regulatory Region DNA Binding
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		26 interactors: ATXN1 CTDSP1 ESR1 IRAK3 ISL1 LHX2 LHX3 LHX6 LHX8 LMO1 LMO2 LMO3 LMO4 LMX1A LMX1B LSM7 POLR1B PSMA1 PSMD10 RLIM SP1 SSBP1 SSBP2 SSBP3 SSBP4 TOLLIP	5 interactors: CITED2 LDB1 MSX1 PAX6 RLIM
Entrez ID		8861	9355
HPRD ID		09144	04786
Ensembl ID		ENSG00000198728	ENSG00000106689
Uniprot IDs		Q86U70	B3KNJ5 P50458
PDB IDs		2XJY 2XJZ 2YPA
Enriched GO Terms of Interacting Partners?		Gene Expression Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Transcription, DNA-templated Regulation Of RNA Metabolic Process RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Central Nervous System Neuron Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Biosynthetic Process Central Nervous System Development Cellular Metabolic Process Brain Development Head Development Developmental Process Organ Development Anatomical Structure Development Forebrain Development Tube Development Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Pattern Specification Process Cell Differentiation Negative Regulation Of Signal Transduction Multicellular Organismal Development Neuron Differentiation Anatomical Structure Morphogenesis System Development Spinal Cord Motor Neuron Differentiation Generation Of Neurons Negative Regulation Of Signaling Transcription From RNA Polymerase II Promoter Neurogenesis	Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Pattern Specification Process Axis Specification Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Mesenchyme Development Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Stem Cell Development Anterior/posterior Pattern Specification Positive Regulation Of Transcription From RNA Polymerase II Promoter Signal Transduction Involved In Regulation Of Gene Expression Anatomical Structure Formation Involved In Morphogenesis Epithelium Development Stem Cell Differentiation Embryo Development Positive Regulation Of Transcription, DNA-templated RNA Metabolic Process Pituitary Gland Development Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Embryonic Organ Development Cellular Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Gland Development Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Tissue Development Diencephalon Development Embryonic Morphogenesis Regulation Of Transcription, DNA-templated Histone H3-K4 Acetylation Pancreatic A Cell Development Forebrain-midbrain Boundary Formation Regulation Of Transcription From RNA Polymerase II Promoter Involved In Somatic Motor Neuron Fate Commitment Random Inactivation Of X Chromosome Transcription-dependent Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cerebellum Development Mesenchymal Cell Development Regulation Of RNA Metabolic Process Cell Proliferation Metencephalon Development
Tagcloud ?		assemble bhlh compatible consensus e12 erythroid erythroleukemia erythropoiesis exist forced g1er hemopoietic immature lbd1 lim lmo2 maintain maturation mediate multiprotein normally oncoprotein others precursors presumed primarily proerythroblast scl whose	ablated conditionally cuboid delete displaying embryonically ependymal expresses homeodomain hypothalamic intersectional isl lim lin mec multiciliated neuroepithelium posteroventral postnatally radial rarres2 rax retaining specification specifying sustaining tanycyte tanycytes ultrastructural
Tagcloud (Difference) ?		assemble bhlh compatible consensus e12 erythroid erythroleukemia erythropoiesis exist forced g1er hemopoietic immature lbd1 lmo2 maintain maturation mediate multiprotein normally oncoprotein others precursors presumed primarily proerythroblast scl whose	ablated conditionally cuboid delete displaying embryonically ependymal expresses homeodomain hypothalamic intersectional isl lin mec multiciliated neuroepithelium posteroventral postnatally radial rarres2 rax retaining specification specifying sustaining tanycyte tanycytes ultrastructural
Tagcloud (Intersection) ?		lim