LHX2 and RLIM

Number of citations of the paper that reports this interaction (PMID 10431247)
31

Data Source:
HPRD (in vitro)

		LHX2	RLIM
Gene Name		LIM homeobox 2	ring finger protein, LIM domain interacting
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleus Nucleoplasm Cytoplasm Transcriptional Repressor Complex
	Molecular Function	RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Chromatin Binding Zinc Ion Binding Sequence-specific DNA Binding	Transcription Corepressor Activity Ubiquitin-protein Transferase Activity Zinc Ion Binding Ligase Activity
	Biological Process	Neural Tube Closure Transcription From RNA Polymerase II Promoter Axon Guidance Mesoderm Development Dorsal/ventral Pattern Formation Olfactory Bulb Development Telencephalon Regionalization Cerebral Cortex Development Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Axon Extension Retina Development In Camera-type Eye Negative Regulation Of Transcription Regulatory Region DNA Binding	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Transcription, DNA-templated Random Inactivation Of X Chromosome
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: CITED2 LDB1 MSX1 PAX6 RLIM	27 interactors: ESR1 ISL1 LDB1 LDB2 LHX1 LHX2 LHX3 LIMK1 LMO2 LNX2 PDLIM1 REXO1 RPS14 SIN3A SMURF2 SNX17 SS18L1 STAT6 STMN1 TERF1 TNFAIP3 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2
Entrez ID		9355	51132
HPRD ID		04786	02304
Ensembl ID		ENSG00000106689	ENSG00000131263
Uniprot IDs		B3KNJ5 P50458	Q9NVW2
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Pattern Specification Process Axis Specification Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Mesenchyme Development Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Stem Cell Development Anterior/posterior Pattern Specification Positive Regulation Of Transcription From RNA Polymerase II Promoter Signal Transduction Involved In Regulation Of Gene Expression Anatomical Structure Formation Involved In Morphogenesis Epithelium Development Stem Cell Differentiation Embryo Development Positive Regulation Of Transcription, DNA-templated RNA Metabolic Process Pituitary Gland Development Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Embryonic Organ Development Cellular Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Gland Development Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Tissue Development Diencephalon Development Embryonic Morphogenesis Regulation Of Transcription, DNA-templated Histone H3-K4 Acetylation Pancreatic A Cell Development Forebrain-midbrain Boundary Formation Regulation Of Transcription From RNA Polymerase II Promoter Involved In Somatic Motor Neuron Fate Commitment Random Inactivation Of X Chromosome Transcription-dependent Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cerebellum Development Mesenchymal Cell Development Regulation Of RNA Metabolic Process Cell Proliferation Metencephalon Development	Protein K48-linked Ubiquitination Protein Polyubiquitination Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Metabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Positive Regulation Of Macromolecule Biosynthetic Process Transcription, DNA-templated Regulation Of DNA-templated Transcription In Response To Stress Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Activation Of Innate Immune Response Negative Regulation Of Gene Expression Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Innate Immune Response RNA Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Protein K11-linked Ubiquitination Negative Regulation Of RNA Biosynthetic Process Cellular Response To Organic Substance Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Negative Regulation Of Chromosome Organization Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Response To Stimulus Positive Regulation Of Immune Response Gene Expression Regulation Of Cell Cycle Phase Transition Negative Regulation Of Protein Ubiquitination Regulation Of Immune System Process Regulation Of Innate Immune Response System Development Mitotic Spindle Assembly Checkpoint
Tagcloud ?		ablated conditionally cuboid delete displaying embryonically ependymal expresses homeodomain hypothalamic intersectional isl lim lin mec multiciliated neuroepithelium posteroventral postnatally radial rarres2 rax retaining specification specifying sustaining tanycyte tanycytes ultrastructural	activators acts clim coactivator deacetylase embryonic encoded enlarge exerts hdac homeodomain inactivation inducer interacts interfering p53 physically playing prevents recruiting repressed repression repressor s1 s4 sin3a sp1 tried
Tagcloud (Difference) ?		ablated conditionally cuboid delete displaying embryonically ependymal expresses hypothalamic intersectional isl lin mec multiciliated neuroepithelium posteroventral postnatally radial rarres2 rax retaining specification specifying sustaining tanycyte tanycytes ultrastructural	activators acts clim coactivator deacetylase embryonic encoded enlarge exerts hdac inactivation inducer interacts interfering p53 physically playing prevents recruiting repressed repression repressor s1 s4 sin3a sp1 tried
Tagcloud (Intersection) ?		homeodomain lim