LDB1 and LHX8

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		LDB1	LHX8
Gene Name		LIM domain binding 1	LIM homeobox 8
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Nucleus Transcription Factor Complex Protein Complex	Female Germ Cell Nucleus
	Molecular Function	RNA Polymerase II Activating Transcription Factor Binding Enhancer Sequence-specific DNA Binding Chromatin Binding Transcription Corepressor Activity Enzyme Binding LIM Domain Binding Protein Homodimerization Activity Protein Self-association	Zinc Ion Binding Sequence-specific DNA Binding
	Biological Process	Transcription-dependent Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery Gastrulation With Mouth Forming Second Hair Follicle Development Transcription, DNA-templated Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Multicellular Organismal Development Anterior/posterior Axis Specification Epithelial Structure Maintenance Wnt Signaling Pathway Cerebellar Purkinje Cell Differentiation Cellular Component Assembly Neuron Differentiation Regulation Of DNA-templated Transcription, Elongation Somatic Stem Cell Maintenance Histone H3-K4 Acetylation Negative Regulation Of Erythrocyte Differentiation Positive Regulation Of Cell Adhesion Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Hemoglobin Biosynthetic Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Learning Or Memory Female Gonad Development Forebrain Neuron Development Odontogenesis Of Dentin-containing Tooth
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		26 interactors: ATXN1 CTDSP1 ESR1 IRAK3 ISL1 LHX2 LHX3 LHX6 LHX8 LMO1 LMO2 LMO3 LMO4 LMX1A LMX1B LSM7 POLR1B PSMA1 PSMD10 RLIM SP1 SSBP1 SSBP2 SSBP3 SSBP4 TOLLIP	5 interactors: KLF3 LDB1 NUTM1 SCYL3 SUV39H1
Entrez ID		8861	431707
HPRD ID		09144	17275
Ensembl ID		ENSG00000198728	ENSG00000162624
Uniprot IDs		Q86U70	Q68G74
PDB IDs		2XJY 2XJZ 2YPA
Enriched GO Terms of Interacting Partners?		Gene Expression Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Transcription, DNA-templated Regulation Of RNA Metabolic Process RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Central Nervous System Neuron Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Biosynthetic Process Central Nervous System Development Cellular Metabolic Process Brain Development Head Development Developmental Process Organ Development Anatomical Structure Development Forebrain Development Tube Development Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Pattern Specification Process Cell Differentiation Negative Regulation Of Signal Transduction Multicellular Organismal Development Neuron Differentiation Anatomical Structure Morphogenesis System Development Spinal Cord Motor Neuron Differentiation Generation Of Neurons Negative Regulation Of Signaling Transcription From RNA Polymerase II Promoter Neurogenesis	Histone H3-K4 Acetylation Transcription-dependent Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery Positive Regulation Of Hemoglobin Biosynthetic Process Peptidyl-lysine Modification Regulation Of Hemoglobin Biosynthetic Process Histone H3-K9 Dimethylation Histone Modification Negative Regulation Of Erythrocyte Differentiation Histone H3-K9 Trimethylation Peptidyl-lysine Dimethylation Cerebellar Purkinje Cell Differentiation Chromatin Silencing At RDNA Cerebellar Purkinje Cell Layer Morphogenesis Epithelial Structure Maintenance Transcription, DNA-templated Negative Regulation Of Circadian Rhythm Chromatin Modification Histone H3-K9 Methylation RNA Biosynthetic Process Peptidyl-lysine Trimethylation Cerebellar Cortex Formation Cell Differentiation In Hindbrain Chromatin Organization Cerebellar Purkinje Cell Layer Development Chromatin Silencing Regulation Of Erythrocyte Differentiation Histone H3-K9 Modification Cerebellar Cortex Morphogenesis Histone H3 Acetylation Cerebellum Morphogenesis RNA Metabolic Process Regulation Of DNA-templated Transcription, Elongation Cellular Protein Modification Process Peptidyl-amino Acid Modification Hindbrain Morphogenesis Gastrulation With Mouth Forming Second Chromosome Organization Gene Expression Cerebellar Cortex Development Somatic Stem Cell Maintenance Anterior/posterior Axis Specification Negative Regulation Of Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Myeloid Cell Differentiation Histone Lysine Methylation Hair Follicle Development
Tagcloud ?		assemble bhlh compatible consensus e12 erythroid erythroleukemia erythropoiesis exist forced g1er hemopoietic immature lbd1 lim lmo2 maintain maturation mediate multiprotein normally oncoprotein others precursors presumed primarily proerythroblast scl whose	apparent busulfan cease closely coincides colonization concomitant cyclophosphamide depletion fas fasl figla follicles germ gfp involve kit nobox offspring ovarian ovaries premature primordial recipient reproductive signalings sox3 th transplanted
Tagcloud (Difference) ?		assemble bhlh compatible consensus e12 erythroid erythroleukemia erythropoiesis exist forced g1er hemopoietic immature lbd1 lim lmo2 maintain maturation mediate multiprotein normally oncoprotein others precursors presumed primarily proerythroblast scl whose	apparent busulfan cease closely coincides colonization concomitant cyclophosphamide depletion fas fasl figla follicles germ gfp involve kit nobox offspring ovarian ovaries premature primordial recipient reproductive signalings sox3 th transplanted
Tagcloud (Intersection) ?