NFATC4 and GPR22

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		NFATC4	GPR22
Description		nuclear factor of activated T cells 4	G protein-coupled receptor 22
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex Cytoplasm Cytosol Nuclear Speck	Plasma Membrane Membrane
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	G Protein-coupled Receptor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Branching Involved In Blood Vessel Morphogenesis Regulation Of DNA-templated Transcription Transcription By RNA Polymerase II Inflammatory Response Heart Development Long-term Memory Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Cell Differentiation Negative Regulation Of Wnt Signaling Pathway Brain-derived Neurotrophic Factor Receptor Signaling Pathway Positive Regulation Of Tumor Necrosis Factor Production Calcineurin-NFAT Signaling Cascade Cellular Response To UV Vascular Associated Smooth Muscle Cell Differentiation Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Cellular Respiration Positive Regulation Of Transcription By RNA Polymerase II Dendrite Morphogenesis Negative Regulation Of Dendrite Morphogenesis Neuron Apoptotic Process Synapse Maturation Long-term Synaptic Potentiation Cellular Response To Lithium Ion Vascular Associated Smooth Muscle Cell Development Negative Regulation Of MiRNA Transcription Negative Regulation Of Synapse Maturation Positive Regulation Of Apoptotic Signaling Pathway	Signal Transduction G Protein-coupled Receptor Signaling Pathway Cell Projection Organization Cellular Response To Hormone Stimulus
Pathways
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Diastolic blood pressure ( 27841878) Height ( 20881960 23563607 25282103) Waist circumference adjusted for body mass index ( 34021172)	Liver enzyme levels (alkaline phosphatase) ( 33972514) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		12 interacting genes: CCNG1 CREBBP GATA4 GPR22 JUP MAPK14 MAPK8 MAPK9 NLGN3 NR1I2 YWHAQ YWHAZ	3 interacting genes: CEBPE NFATC4 TFAP2C
Entrez ID		4776	2845
HPRD ID		09096	03552
Ensembl ID		ENSG00000100968	ENSG00000172209
Uniprot IDs		Q14934	B3KV13 Q3KNS9 Q99680
PDB IDs		2YRP
Enriched GO Terms of Interacting Partners?		MAP Kinase Activity Protein Phosphatase Binding JUN Kinase Activity Regulation Of Protein Localization To Nucleus NFAT Protein Binding Response To Mechanical Stimulus Intracellular Signaling Cassette Response To Nutrient Levels Cellular Senescence Energy Homeostasis MAPK Cascade Positive Regulation Of Protein Localization To Nucleus Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Intracellular Signal Transduction Positive Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Positive Regulation Of Cyclase Activity Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Fc-epsilon Receptor Signaling Pathway Response To UV Negative Regulation Of RNA Metabolic Process Cellular Response To Oxygen-containing Compound Regulation Of Cardiac Muscle Cell Contraction Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Immune Response Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process DNA-binding Transcription Factor Binding Regulation Of Protein Localization Multicellular Organismal-level Homeostasis Regulation Of MRNA Stability Cellular Response To Molecule Of Bacterial Origin Canonical Inflammasome Complex Assembly Positive Regulation Of Protein Import Into Nucleus Regulation Of Macromolecule Metabolic Process Regulation Of RNA Stability Signal Transduction Nuclear Receptor Binding Rhythmic Process Cellular Response To Nutrient Levels Positive Regulation Of Macromolecule Biosynthetic Process Gamma-catenin-TCF7L2 Complex Fc Receptor Signaling Pathway JUN Phosphorylation Regulation Of Biological Quality	DNA-templated Transcription Sequence-specific Double-stranded DNA Binding DNA-binding Transcription Factor Activity Nucleobase-containing Compound Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of Transcription By RNA Polymerase II Dichotomous Subdivision Of Terminal Units Involved In Mammary Gland Duct Morphogenesis RNA Metabolic Process Negative Regulation Of Synapse Maturation Morula Formation Macromolecule Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Brain-derived Neurotrophic Factor Receptor Signaling Pathway Transcription By RNA Polymerase II DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Germ-line Stem Cell Population Maintenance Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation Morphogenesis Of An Epithelium Inner Cell Mass Cell Differentiation Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process Negative Regulation Of Dendrite Morphogenesis Vascular Associated Smooth Muscle Cell Differentiation Sebaceous Gland Development Forebrain Neuron Fate Commitment Tissue Morphogenesis DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Keratinocyte Development Vascular Associated Smooth Muscle Cell Development Cell Differentiation Negative Regulation Of Synapse Organization Cellular Response To Lithium Ion Synapse Maturation Mammary Gland Epithelial Cell Proliferation Regulation Of Transcription By RNA Polymerase II Response To Lithium Ion Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Trophectodermal Cell Differentiation Calcineurin-NFAT Signaling Cascade Positive Regulation Of Biosynthetic Process Cellular Developmental Process Smooth Muscle Cell Differentiation Negative Regulation Of MiRNA Transcription Regulation Of Synapse Maturation
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