NFATC4 and MAPK9

Number of citations of the paper that reports this interaction (PubMedID 17875713)
0

Data Source:
BioGRID (enzymatic study)

		NFATC4	MAPK9
Description		nuclear factor of activated T cells 4	mitogen-activated protein kinase 9
Image
GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex Cytoplasm Cytosol Nuclear Speck	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Plasma Membrane Nuclear Speck Schaffer Collateral - CA1 Synapse
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity JUN Kinase Activity MAP Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Branching Involved In Blood Vessel Morphogenesis Regulation Of DNA-templated Transcription Transcription By RNA Polymerase II Inflammatory Response Heart Development Long-term Memory Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Cell Differentiation Negative Regulation Of Wnt Signaling Pathway Brain-derived Neurotrophic Factor Receptor Signaling Pathway Positive Regulation Of Tumor Necrosis Factor Production Calcineurin-NFAT Signaling Cascade Cellular Response To UV Vascular Associated Smooth Muscle Cell Differentiation Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Cellular Respiration Positive Regulation Of Transcription By RNA Polymerase II Dendrite Morphogenesis Negative Regulation Of Dendrite Morphogenesis Neuron Apoptotic Process Synapse Maturation Long-term Synaptic Potentiation Cellular Response To Lithium Ion Vascular Associated Smooth Muscle Cell Development Negative Regulation Of MiRNA Transcription Negative Regulation Of Synapse Maturation Positive Regulation Of Apoptotic Signaling Pathway	MAPK Cascade Protein Phosphorylation JNK Cascade Positive Regulation Of Gene Expression Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Reactive Oxygen Species Fc-epsilon Receptor Signaling Pathway Regulation Of Circadian Rhythm Regulation Of MRNA Stability Response To Cadmium Ion Rhythmic Process Modulation Of Chemical Synaptic Transmission MRNA Destabilization Protein Localization To Tricellular Tight Junction Positive Regulation Of Podosome Assembly Cellular Senescence Inflammatory Response To Wounding Apoptotic Signaling Pathway Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Apoptotic Signaling Pathway
Pathways			Oxidative Stress Induced Senescence FCERI mediated MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Activation of the AP-1 family of transcription factors Signaling by ALK fusions and activated point mutants
Drugs			Minocycline N-{3-[5-(1H-1,2,4-triazol-3-yl)-1H-indazol-3-yl]phenyl}furan-2-carboxamide Fostamatinib Halicin
Diseases
GWAS		Appendicular lean mass ( 33097823) Diastolic blood pressure ( 27841878) Height ( 20881960 23563607 25282103) Waist circumference adjusted for body mass index ( 34021172)	Appendicular lean mass ( 33097823) Blood protein levels ( 30072576)
Interacting Genes		12 interacting genes: CCNG1 CREBBP GATA4 GPR22 JUP MAPK14 MAPK8 MAPK9 NLGN3 NR1I2 YWHAQ YWHAZ	111 interacting genes: ACP5 AKT1 ARRB1 ARRB2 ATF2 ATF7 BCL2L1 BCL2L11 BTRC C1orf105 C1orf94 CASP3 CBLL2 CCDC33 CDC16 CDC25B CDC25C CEP126 CEP44 CLU CTBP1 CTNNB1 DCX DTX3 DUSP10 DUSP16 DUSP19 DUSP4 EEF2K EFHC2 EGFR ELK1 ELK3 ENKD1 FBXO7 GFAP GOLGA6A GRB2 GSC2 H3-3A HDAC9 HSF1 IHO1 IRS1 ITGB3BP JDP2 JUN JUNB JUND KLHL8 KPNA3 L3MBTL3 LHX3 LMAN2 LNX1 LNX2 LZTS1 MACF1 MAP2K4 MAP2K7 MAP3K1 MAP3K10 MAPK8IP1 MAPK8IP2 MAPK8IP3 MAPKAPK5 MAPKBP1 MAPT MCRS1 MED12L MEOX1 MLIP NCF1 NCSTN NFATC3 NFATC4 NHSL2 PAX5 PBX4 PICK1 POU6F2 PPARG PRKD1 PSEN1 RB1 RPS6KB1 RSPO4 SAXO1 SDCBP SF3B4 SH3BP5 SHMT1 SMAD2 SMAD3 SMCO3 SSU72 TCP10L TEX11 TOB1 TP53 TRAF2 TUSC2 WDR62 XPNPEP1 XPO7 ZBTB25 ZC2HC1C ZFTRAF1 ZNF138 ZNF559 ZNHIT1
Entrez ID		4776	5601
HPRD ID		09096	04206
Ensembl ID		ENSG00000100968	ENSG00000050748
Uniprot IDs		Q14934	D7R525 P45984
PDB IDs		2YRP	3E7O 3NPC 7CML 7N8T 8ELC
Enriched GO Terms of Interacting Partners?		MAP Kinase Activity Protein Phosphatase Binding JUN Kinase Activity Regulation Of Protein Localization To Nucleus NFAT Protein Binding Response To Mechanical Stimulus Intracellular Signaling Cassette Response To Nutrient Levels Cellular Senescence Energy Homeostasis MAPK Cascade Positive Regulation Of Protein Localization To Nucleus Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Intracellular Signal Transduction Positive Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Positive Regulation Of Cyclase Activity Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Fc-epsilon Receptor Signaling Pathway Response To UV Negative Regulation Of RNA Metabolic Process Cellular Response To Oxygen-containing Compound Regulation Of Cardiac Muscle Cell Contraction Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Immune Response Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process DNA-binding Transcription Factor Binding Regulation Of Protein Localization Multicellular Organismal-level Homeostasis Regulation Of MRNA Stability Cellular Response To Molecule Of Bacterial Origin Canonical Inflammasome Complex Assembly Positive Regulation Of Protein Import Into Nucleus Regulation Of Macromolecule Metabolic Process Regulation Of RNA Stability Signal Transduction Nuclear Receptor Binding Rhythmic Process Cellular Response To Nutrient Levels Positive Regulation Of Macromolecule Biosynthetic Process Gamma-catenin-TCF7L2 Complex Fc Receptor Signaling Pathway JUN Phosphorylation Regulation Of Biological Quality	Intracellular Signaling Cassette Intracellular Signal Transduction MAPK Cascade Negative Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Protein Kinase Binding Cellular Developmental Process Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Activity Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Apoptotic Signaling Pathway Nucleus Positive Regulation Of Transcription By RNA Polymerase II JNK Cascade JUN Kinase Binding Programmed Cell Death Cell Death Negative Regulation Of Apoptotic Process Cytoplasm Positive Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cell Population Proliferation Regulation Of Macromolecule Metabolic Process Protein Binding Negative Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Neuron Apoptotic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Cell Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle Positive Regulation Of Signaling Positive Regulation Of Signal Transduction Regulation Of Primary Metabolic Process Regulation Of Intracellular Signal Transduction Positive Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process
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