ANKRD13A and LAPTM5

Number of citations of the paper that reports this interaction (PubMedID 15231748)
54

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ANKRD13A	LAPTM5
Description		ankyrin repeat domain 13A	lysosomal protein transmembrane 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endosome Late Endosome Plasma Membrane Membrane Perinuclear Region Of Cytoplasm	Lysosome Lysosomal Membrane Cytosol Plasma Membrane Membrane Transport Vesicle Cytoplasmic Vesicle Protein-containing Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Ubiquitin-modified Protein Reader Activity	Protein Binding Enzyme Binding Ubiquitin Protein Ligase Binding Protein Sequestering Activity
	Biological Process	Negative Regulation Of Receptor Internalization Negative Regulation Of Protein Localization To Endosome	Defense Response To Tumor Cell Positive Regulation Of Cytokine Production Involved In Immune Response Protein Targeting To Lysosome Intracellular Protein Transport Induction Of Programmed Cell Death Positive Regulation Of Protein Ubiquitination Negative Regulation Of Type II Interferon Production Negative Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of MAPK Cascade Negative Regulation Of Activated T Cell Proliferation Negative Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Activation Negative Regulation Of B Cell Activation Positive Regulation Of Macrophage Cytokine Production Protein Localization To Lysosome Golgi To Lysosome Transport Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Lysosomal Membrane Permeability Negative Regulation Of Pre-B Cell Receptor Expression Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Autophagic Cell Death Cellular Response To Leukemia Inhibitory Factor Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Receptor Catabolic Process
Pathways
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Metabolite levels (MHPG) ( 23319000) Systolic blood pressure ( 30578418)	Loneliness ( 27629369) Loneliness (linear analysis) ( 27629369) Neutrophil count ( 32888494) White blood cell count ( 32888494)
Interacting Genes		12 interacting genes: FBXO25 GRB2 LAPTM5 MFHAS1 QDPR RIPK1 RNF11 SMAD5 SMURF1 UBC VCP WBP2	38 interacting genes: AIG1 ANKRD13A ARLN CLDN19 CYB5R3 DCUN1D1 DISP1 EPN1 EPN2 EPN3 EPS15 GYPA HERC1 HEY1 HEYL HMOX2 HUWE1 INSIG2 ITCH KIR3DL3 KRT7 LDLRAD1 MRPL18 NEDD4L RNF168 RPRM RTP2 SLC22A2 SMURF2 TNFAIP3 TOM1L2 UBA52 UBAC1 UBC UBE2J1 USP13 VAMP1 WWP1
Entrez ID		88455	7805
HPRD ID		12458	03280
Ensembl ID		ENSG00000076513	ENSG00000162511
Uniprot IDs		Q3ZTS7 Q8IZ07 Q9Y5A3	Q13571 Q5TBB8
PDB IDs
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Binding Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Intracellular Signal Transduction I-SMAD Binding Protein Ubiquitination Protein Modification By Small Protein Conjugation Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Signal Transduction Post-translational Protein Modification Vacuolar Transport Regulation Of Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Ubiquitin-dependent Protein Catabolic Process Guanyl-nucleotide Exchange Factor Adaptor Activity Regulation Of Cell Communication Cytoplasm Regulation Of Signaling Mitochondrion Dihydrobiopterin Metabolic Process 6,7-dihydropteridine Reductase Activity Protein Modification Process Macromolecule Catabolic Process Modification-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Flavin Adenine Dinucleotide Catabolic Process Positive Regulation Of Intracellular Signal Transduction Induction Of Programmed Cell Death Negative Regulation Of Pre-B Cell Receptor Expression Positive Regulation Of Lysosomal Membrane Permeability Protein Targeting To Vacuole Engulfment Of Target By Autophagosome Canonical NF-kappaB Signal Transduction Regulation Of MAPK Cascade Establishment Of Protein Localization To Vacuole Positive Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Reactive Oxygen Species Metabolic Process Proteolysis Involved In Protein Catabolic Process Catabolic Process Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Response To Cytokine Stimulus Regulation Of Intracellular Signal Transduction Grb2-EGFR Complex Negative Regulation Of Fas Signaling Pathway Erythrocyte Differentiation VCP-NSFL1C Complex Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control	Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Ubiquitination Ubiquitin-protein Transferase Activity Clathrin Vesicle Coat Clathrin Binding Ubiquitin Binding Ubiquitin Ligase Complex Protein Modification Process Proteolysis Ubiquitin Protein Ligase Activity Proteolysis Involved In Protein Catabolic Process Histone Ubiquitin Ligase Activity Modification-dependent Protein Catabolic Process Protein Polyubiquitination Protein Metabolic Process Protein K48-linked Ubiquitination Symbiont Entry Into Host Cell Catabolic Process Endosome Protein Monoubiquitination Macromolecule Catabolic Process Import Into Cell Endocytosis Biological Process Involved In Interaction With Host Plasma Membrane Protein Tag Activity Receptor Internalization Clathrin-coated Pit Ubiquitin-ubiquitin Ligase Activity Proteasomal Protein Catabolic Process Pulmonary Valve Morphogenesis Clathrin-coated Vesicle Tolerance Induction Proteasome Binding Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Protein Branched Polyubiquitination Endocardial Cushion Morphogenesis Circulatory System Development Mitochondrial Outer Membrane Membrane Extracellular Exosome Positive Regulation Of Protein Catabolic Process Negative Regulation Of Sprouting Angiogenesis Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Protein K63-linked Deubiquitination K63-linked Polyubiquitin Modification-dependent Protein Binding Ubiquitin-like Protein Ligase Binding Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
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