ANKRD13A and QDPR

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ANKRD13A	QDPR
Description		ankyrin repeat domain 13A	quinoid dihydropteridine reductase
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endosome Late Endosome Plasma Membrane Membrane Perinuclear Region Of Cytoplasm	Cytoplasm Mitochondrion Cytosol Extracellular Exosome
	Molecular Function	Ubiquitin-modified Protein Reader Activity	6,7-dihydropteridine Reductase Activity Electron Transfer Activity Oxidoreductase Activity NADPH Binding NADH Binding
	Biological Process	Negative Regulation Of Receptor Internalization Negative Regulation Of Protein Localization To Endosome	Amino Acid Metabolic Process L-phenylalanine Catabolic Process Tetrahydrobiopterin Biosynthetic Process Pteridine-containing Compound Metabolic Process Dihydrobiopterin Metabolic Process
Pathways			Phenylalanine metabolism
Drugs			NADH 2-(N-morpholino)ethanesulfonic acid
Diseases			Phenylketonuria (PKU); Hyperphenylalaninemia, BH4-deficient
GWAS		Bipolar disorder ( 31043756) Metabolite levels (MHPG) ( 23319000) Systolic blood pressure ( 30578418)	Blood protein levels ( 30072576)
Interacting Genes		12 interacting genes: FBXO25 GRB2 LAPTM5 MFHAS1 QDPR RIPK1 RNF11 SMAD5 SMURF1 UBC VCP WBP2	5 interacting genes: ANKRD13A CASP8 KRAS PAH RXFP4
Entrez ID		88455	5860
HPRD ID		12458	02025
Ensembl ID		ENSG00000076513	ENSG00000151552
Uniprot IDs		Q3ZTS7 Q8IZ07 Q9Y5A3	A0A140VKA9 P09417
PDB IDs			1HDR
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Binding Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Intracellular Signal Transduction I-SMAD Binding Protein Ubiquitination Protein Modification By Small Protein Conjugation Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Signal Transduction Post-translational Protein Modification Vacuolar Transport Regulation Of Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Ubiquitin-dependent Protein Catabolic Process Guanyl-nucleotide Exchange Factor Adaptor Activity Regulation Of Cell Communication Cytoplasm Regulation Of Signaling Mitochondrion Dihydrobiopterin Metabolic Process 6,7-dihydropteridine Reductase Activity Protein Modification Process Macromolecule Catabolic Process Modification-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Flavin Adenine Dinucleotide Catabolic Process Positive Regulation Of Intracellular Signal Transduction Induction Of Programmed Cell Death Negative Regulation Of Pre-B Cell Receptor Expression Positive Regulation Of Lysosomal Membrane Permeability Protein Targeting To Vacuole Engulfment Of Target By Autophagosome Canonical NF-kappaB Signal Transduction Regulation Of MAPK Cascade Establishment Of Protein Localization To Vacuole Positive Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Reactive Oxygen Species Metabolic Process Proteolysis Involved In Protein Catabolic Process Catabolic Process Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Response To Cytokine Stimulus Regulation Of Intracellular Signal Transduction Grb2-EGFR Complex Negative Regulation Of Fas Signaling Pathway Erythrocyte Differentiation VCP-NSFL1C Complex Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control	Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development GMP Binding Forebrain Astrocyte Development Tyrosine Biosynthetic Process Phenylalanine 4-monooxygenase Activity Tyrosine Biosynthetic Process, By Oxidation Of Phenylalanine Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Pteridine As One Donor, And Incorporation Of One Atom Of Oxygen Negative Regulation Of Protein Localization To Endosome Death Effector Domain Binding Response To Isolation Stress Positive Regulation Of Pyroptotic Inflammatory Response Response To Anesthetic Ripoptosome Self Proteolysis Response To Cobalt Ion Death-inducing Signaling Complex Regulation Of Neuron Apoptotic Process CD95 Death-inducing Signaling Complex TRAIL-activated Apoptotic Signaling Pathway Mitochondrial Outer Membrane LRR Domain Binding Type I Pneumocyte Differentiation Response To Gravity L-phenylalanine Catabolic Process Ubiquitin-modified Protein Reader Activity Galanin Receptor Activity Positive Regulation Of Feeding Behavior Myoblast Proliferation Positive Regulation Of Macrophage Differentiation Protein-containing Complex Binding Positive Regulation Of Cellular Senescence Tyrosine Metabolic Process Negative Regulation Of Receptor Internalization
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