ANKRD13A and RIPK1

Number of citations of the paper that reports this interaction (PubMedID 34839354)
50

Data Source:
BioGRID (affinity chromatography technology, pull down)

		ANKRD13A	RIPK1
Description		ankyrin repeat domain 13A	receptor interacting serine/threonine kinase 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endosome Late Endosome Plasma Membrane Membrane Perinuclear Region Of Cytoplasm	Cytoplasm Mitochondrion Cytosol Plasma Membrane Endosome Membrane Membrane Death-inducing Signaling Complex Protein-containing Complex Receptor Complex Ripoptosome
	Molecular Function	Ubiquitin-modified Protein Reader Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity JUN Kinase Kinase Kinase Activity Death Receptor Binding Protein Binding ATP Binding Kinase Activity Transferase Activity Ubiquitin Protein Ligase Binding Signaling Adaptor Activity Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding Death Domain Binding Protein Serine Kinase Activity
	Biological Process	Negative Regulation Of Receptor Internalization Negative Regulation Of Protein Localization To Endosome	MAPK Cascade Positive Regulation Of Protein Phosphorylation Apoptotic Process Inflammatory Response Response To Oxidative Stress Signal Transduction Canonical NF-kappaB Signal Transduction Positive Regulation Of Gene Expression Programmed Cell Death Protein Catabolic Process Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Tumor Necrosis Factor-mediated Signaling Pathway Response To Tumor Necrosis Factor Intracellular Signal Transduction Peptidyl-serine Autophosphorylation Positive Regulation Of Phosphorylation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of MAPK Cascade Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Macrophage Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Protein Autophosphorylation Positive Regulation Of Inflammatory Response Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Necroptotic Process Positive Regulation Of Necroptotic Process Negative Regulation Of Necroptotic Process Positive Regulation Of Programmed Necrotic Cell Death Positive Regulation Of Interleukin-6-mediated Signaling Pathway T Cell Apoptotic Process Necroptotic Process Cellular Response To Hydrogen Peroxide Cellular Response To Tumor Necrosis Factor Cellular Response To Growth Factor Stimulus Extrinsic Apoptotic Signaling Pathway Programmed Necrotic Cell Death Ripoptosome Assembly Necroptotic Signaling Pathway Positive Regulation Of Execution Phase Of Apoptosis Ripoptosome Assembly Involved In Necroptotic Process Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of MiRNA Processing Amyloid Fibril Formation Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways			Caspase activation via Death Receptors in the presence of ligand TICAM1, RIP1-mediated IKK complex recruitment RIP-mediated NFkB activation via ZBP1 TRIF-mediated programmed cell death TRP channels Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway Regulation of necroptotic cell death Ub-specific processing proteases Ovarian tumor domain proteases Dimerization of procaspase-8 TNF signaling TLR3-mediated TICAM1-dependent programmed cell death NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 IKK complex recruitment mediated by RIP1 Potential therapeutics for SARS Microbial modulation of RIPK1-mediated regulated necrosis SARS-CoV-1-mediated effects on programmed cell death Defective RIPK1-mediated regulated necrosis
Drugs			Fostamatinib
Diseases
GWAS		Bipolar disorder ( 31043756) Metabolite levels (MHPG) ( 23319000) Systolic blood pressure ( 30578418)	Cerebral white matter volume ( 31530798) Idiopathic osteonecrosis of the femoral head ( 28000841)
Interacting Genes		12 interacting genes: FBXO25 GRB2 LAPTM5 MFHAS1 QDPR RIPK1 RNF11 SMAD5 SMURF1 UBC VCP WBP2	49 interacting genes: ANKRD13A CASP8 CCDC50 CDC42BPB CFLAR CRADD CTNNB1 EGFR FADD FAS HSP90AA1 IKBKE IKBKG ITCH MAP3K14 MAP3K3 MAP3K8 MTDH NFKB1 NUMBL OTUD1 PPDPF PTK2 RIPK3 RNF11 RNF216 RPA1 SQSTM1 TAX1BP1 TBK1 TICAM1 TNF TNFAIP3 TNFRSF10A TNFRSF10B TNFRSF1A TRADD TRAF1 TRAF2 TRAF3 TRAF5 TRAF6 TRIM38 TRIM72 TRPC4AP UBE2N USP21 YOD1 ZFAND5
Entrez ID		88455	8737
HPRD ID		12458	04583
Ensembl ID		ENSG00000076513	ENSG00000137275
Uniprot IDs		Q3ZTS7 Q8IZ07 Q9Y5A3	Q13546
PDB IDs			4ITH 4ITI 4ITJ 4NEU 5HX6 5TX5 5V7Z 6AC5 6C3E 6C4D 6HHO 6NW2 6NYH 6OCQ 6R5F 6RLN 7CJB 7FCZ 7FD0 7XMK 7YDX 8I2N
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Binding Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Intracellular Signal Transduction I-SMAD Binding Protein Ubiquitination Protein Modification By Small Protein Conjugation Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Signal Transduction Post-translational Protein Modification Vacuolar Transport Regulation Of Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Ubiquitin-dependent Protein Catabolic Process Guanyl-nucleotide Exchange Factor Adaptor Activity Regulation Of Cell Communication Cytoplasm Regulation Of Signaling Mitochondrion Dihydrobiopterin Metabolic Process 6,7-dihydropteridine Reductase Activity Protein Modification Process Macromolecule Catabolic Process Modification-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Flavin Adenine Dinucleotide Catabolic Process Positive Regulation Of Intracellular Signal Transduction Induction Of Programmed Cell Death Negative Regulation Of Pre-B Cell Receptor Expression Positive Regulation Of Lysosomal Membrane Permeability Protein Targeting To Vacuole Engulfment Of Target By Autophagosome Canonical NF-kappaB Signal Transduction Regulation Of MAPK Cascade Establishment Of Protein Localization To Vacuole Positive Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Reactive Oxygen Species Metabolic Process Proteolysis Involved In Protein Catabolic Process Catabolic Process Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Response To Cytokine Stimulus Regulation Of Intracellular Signal Transduction Grb2-EGFR Complex Negative Regulation Of Fas Signaling Pathway Erythrocyte Differentiation VCP-NSFL1C Complex Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control	Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Apoptotic Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Cell Death Programmed Cell Death Tumor Necrosis Factor-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of Apoptotic Process Positive Regulation Of Signal Transduction Regulation Of Programmed Cell Death Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Cellular Response To Mechanical Stimulus Tumor Necrosis Factor Receptor Binding Positive Regulation Of Defense Response Response To Mechanical Stimulus Non-canonical NF-kappaB Signal Transduction Signaling Adaptor Activity Apoptotic Signaling Pathway Signal Transduction Ubiquitin Protein Ligase Binding Regulation Of Signal Transduction Intracellular Signal Transduction Activation Of Immune Response Extrinsic Apoptotic Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Death-inducing Signaling Complex Regulation Of Defense Response Regulation Of Immune Response Response To Virus Positive Regulation Of Immune Response Immune System Process TRAIL-activated Apoptotic Signaling Pathway Cytokine-mediated Signaling Pathway Immune Response-regulating Signaling Pathway Response To External Biotic Stimulus Positive Regulation Of Protein Metabolic Process Regulation Of Signaling Activation Of Innate Immune Response Regulation Of Cell Communication Defense Response Immune Response-activating Signaling Pathway Positive Regulation Of DNA-binding Transcription Factor Activity Response To Other Organism Positive Regulation Of Innate Immune Response Positive Regulation Of Immune System Process Regulation Of Immune System Process
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