PLXNA1

Description		plexin A1
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GO Annotations	Cellular Component	Semaphorin Receptor Complex Nucleoplasm Cytosol Plasma Membrane Membrane Synapse Extracellular Exosome Glutamatergic Synapse
	Molecular Function	Semaphorin Receptor Activity
	Biological Process	T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Synapse Assembly Regulation Of Smooth Muscle Cell Migration Olfactory Nerve Formation Gonadotrophin-releasing Hormone Neuronal Migration To The Hypothalamus Regulation Of Cell Migration Dichotomous Subdivision Of Terminal Units Involved In Salivary Gland Branching Semaphorin-plexin Signaling Pathway Neuron Projection Guidance Neuron Projection Extension
Pathways		Sema3A PAK dependent Axon repulsion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion CRMPs in Sema3A signaling CRMPs in Sema3A signaling Other semaphorin interactions RHOD GTPase cycle RND1 GTPase cycle
Drugs
Diseases
GWAS		Alcoholic chronic pancreatitis ( 28754779) Blood protein levels ( 30072576) Platelet count ( 32888494) Refractive error ( 32231278) Systolic blood pressure ( 31469255) Weight ( 28552196) Whole-brain volume ( 21116278)
Novel Interacting Genes		1 novel interacting genes: FGFR2
Interacting Genes		10 interacting genes: AKT1 FES L1CAM NRP1 NRP2 PLXNB1 RAC1 RHOD RND1 SEMA6D
Entrez ID		5361
HPRD ID		11868
Ensembl ID		ENSG00000114554
Uniprot IDs		Q9UIW2
PDB IDs		7Y4P 7Y4Q
Enriched GO Terms of Interacting Partners?		Semaphorin-plexin Signaling Pathway Regulation Of Cellular Component Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Regulation Of Locomotion Positive Regulation Of Cell Projection Organization Regulation Of Cell Motility Locomotion Chemotaxis Cell Projection Organization Semaphorin Receptor Activity Semaphorin Receptor Complex Regulation Of Neuron Projection Development Regulation Of Cell Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Neuron Projection Guidance Axon Guidance Regulation Of Cell Development Anatomical Structure Arrangement Regulation Of Anatomical Structure Morphogenesis Cell Migration Regulation Of Cytoskeleton Organization Vestibulocochlear Nerve Structural Organization Dorsal Root Ganglion Morphogenesis Sensory Neuron Axon Guidance Facioacoustic Ganglion Development Plasma Membrane Positive Regulation Of Cell Migration Regulation Of Cell Migration Motor Neuron Axon Guidance Regulation Of Cell Differentiation Positive Regulation Of Cell Motility Outflow Tract Septum Morphogenesis Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Locomotion Cell Motility Regulation Of Developmental Growth Ameboidal-type Cell Migration Ventral Trunk Neural Crest Cell Migration Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Axonogenesis Regulation Of Organelle Organization Sympathetic Neuron Projection Guidance Trigeminal Ganglion Development Positive Regulation Of Developmental Growth Cranial Ganglion Development Trunk Neural Crest Cell Migration Cell Surface Receptor Signaling Pathway Positive Regulation Of Developmental Process Regulation Of Nervous System Development
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