PLXNA1 and PLXNB1

Number of citations of the paper that reports this interaction (PMID 12559962)
3

Data Source:
HPRD (two hybrid, in vivo)

		PLXNA1	PLXNB1
Gene Name		plexin A1	plexin B1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Semaphorin Receptor Complex Nucleus Cytoplasm Plasma Membrane Integral Component Of Membrane Extracellular Vesicular Exosome	Semaphorin Receptor Complex Extracellular Region Intracellular Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Receptor Activity Semaphorin Receptor Activity	Receptor Activity Transmembrane Signaling Receptor Activity Protein Binding Semaphorin Receptor Activity Semaphorin Receptor Binding GTPase Activating Protein Binding
	Biological Process	Multicellular Organismal Development Axon Guidance Regulation Of Smooth Muscle Cell Migration Dichotomous Subdivision Of Terminal Units Involved In Salivary Gland Branching Semaphorin-plexin Signaling Pathway	Negative Regulation Of Cell Adhesion Signal Transduction Axon Guidance Regulation Of Cell Shape Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Cell Migration Positive Regulation Of Rho GTPase Activity Negative Regulation Of Osteoblast Proliferation Intracellular Signal Transduction Ossification Involved In Bone Maturation Neuron Projection Morphogenesis Positive Regulation Of Axonogenesis Regulation Of Cytoskeleton Organization Semaphorin-plexin Signaling Pathway Semaphorin-plexin Signaling Pathway Involved In Bone Trabecula Morphogenesis
Pathways		Axon guidance Semaphorin interactions Other semaphorin interactions Sema3A PAK dependent Axon repulsion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion CRMPs in Sema3A signaling	Signaling by GPCR GPCR downstream signaling Axon guidance Semaphorin interactions G alpha (12/13) signalling events Sema4D mediated inhibition of cell attachment and migration Sema4D in semaphorin signaling Sema4D induced cell migration and growth-cone collapse
Drugs
Diseases
GWAS		MRI atrophy measures ( 21116278)
Protein-Protein Interactions		7 interactors: AKT1 FES NRP1 PLXNB1 RHOD RND1 SEMA6D	10 interactors: ARHGEF11 ARHGEF12 KMT2A MET PLXNA1 RAC1 RND1 RND3 SEMA4B SEMA4D
Entrez ID		5361	5364
HPRD ID		11868	03032
Ensembl ID		ENSG00000114554	ENSG00000164050
Uniprot IDs		Q9UIW2	O43157
PDB IDs			2JPH 2OS6 2R2O 2REX 3HM6 3OL2 3SU8 3SUA
Enriched GO Terms of Interacting Partners?		Cell Projection Organization Axon Guidance Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Regulation Of Cell Adhesion Regulation Of Cell Motility Neuron Projection Morphogenesis Regulation Of Locomotion Regulation Of Cellular Component Movement Cell Morphogenesis Involved In Differentiation Generation Of Neurons Neurogenesis Neuron Projection Development Cell Projection Morphogenesis Positive Regulation Of Cell Migration Cell Part Morphogenesis Positive Regulation Of Cell Motility Cell Development Response To External Stimulus Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Neuron Development Regulation Of Neuron Projection Development Cell Morphogenesis Negative Regulation Of Osteoblast Proliferation Neuron Differentiation Nervous System Development Regulation Of Cell Projection Organization Locomotion Regulation Of Neuron Differentiation Regulation Of Cell Migration Movement Of Cell Or Subcellular Component Positive Regulation Of Smooth Muscle Cell Migration Regulation Of Osteoblast Proliferation Regulation Of Neurogenesis Positive Regulation Of Neuron Projection Development Semaphorin-plexin Signaling Pathway Regulation Of Cell Development Positive Regulation Of Cell Differentiation Positive Regulation Of Cell Projection Organization Cell Differentiation Regulation Of Actin Cytoskeleton Reorganization Regulation Of Smooth Muscle Cell Migration Regulation Of Cellular Component Organization Regulation Of Organelle Organization Positive Regulation Of Neuron Differentiation Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Endothelial Cell Proliferation	Axon Guidance Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Semaphorin-plexin Signaling Pathway Cell Morphogenesis Involved In Differentiation Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Neuron Development Cell Morphogenesis Neuron Differentiation Cell Projection Organization Locomotion Nervous System Development Movement Of Cell Or Subcellular Component Generation Of Neurons Neurogenesis System Development Cell Development Response To External Stimulus Small GTPase Mediated Signal Transduction Multicellular Organismal Development Anatomical Structure Development Cell Differentiation Regulation Of Rho Protein Signal Transduction Anatomical Structure Morphogenesis Developmental Process Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Cell Migration Actin Cytoskeleton Organization Neurotrophin TRK Receptor Signaling Pathway Regulation Of Cell Motility Neurotrophin Signaling Pathway Actin Filament-based Process Regulation Of Ras Protein Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Rho GTPase Activity Regulation Of Locomotion Regulation Of Cellular Component Movement Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Rho GTPase Activity Positive Regulation Of Catalytic Activity Epithelial Cell Morphogenesis
Tagcloud ?			4d actively architecture broadly cd100 checkpoint colon26 ctla disrupts durable erbb2 immunomodulatory immunotherapies infiltration leukocytes margins microenvironment milieu neutralization orchestrated plexin rejection sema4d semaphorin shifts strikingly synergistically tme whereby
Tagcloud (Difference) ?			4d actively architecture broadly cd100 checkpoint colon26 ctla disrupts durable erbb2 immunomodulatory immunotherapies infiltration leukocytes margins microenvironment milieu neutralization orchestrated plexin rejection sema4d semaphorin shifts strikingly synergistically tme whereby
Tagcloud (Intersection) ?