PLXNA1 and PLXNB1

Number of citations of the paper that reports this interaction (PubMedID 25315821)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid, in vivo)

		PLXNA1	PLXNB1
Description		plexin A1	plexin B1
Image
GO Annotations	Cellular Component	Semaphorin Receptor Complex Nucleoplasm Cytosol Plasma Membrane Membrane Synapse Extracellular Exosome Glutamatergic Synapse	Semaphorin Receptor Complex Extracellular Region Plasma Membrane Membrane Postsynaptic Membrane Glutamatergic Synapse
	Molecular Function	Semaphorin Receptor Activity	Transmembrane Signaling Receptor Activity GTPase Activator Activity Protein Binding Semaphorin Receptor Activity Semaphorin Receptor Binding GTPase Activating Protein Binding
	Biological Process	T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Synapse Assembly Regulation Of Smooth Muscle Cell Migration Olfactory Nerve Formation Gonadotrophin-releasing Hormone Neuronal Migration To The Hypothalamus Regulation Of Cell Migration Dichotomous Subdivision Of Terminal Units Involved In Salivary Gland Branching Semaphorin-plexin Signaling Pathway Neuron Projection Guidance Neuron Projection Extension	Negative Regulation Of Cell Adhesion Synapse Assembly Regulation Of Cell Shape Cell Migration Regulation Of Cell Migration Negative Regulation Of Osteoblast Proliferation Positive Regulation Of Rho Protein Signal Transduction Intracellular Signal Transduction Positive Regulation Of GTPase Activity Ossification Involved In Bone Maturation Neuron Projection Morphogenesis Positive Regulation Of Axonogenesis Regulation Of Cytoskeleton Organization Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Semaphorin-plexin Signaling Pathway Inhibitory Synapse Assembly
Pathways		Sema3A PAK dependent Axon repulsion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion CRMPs in Sema3A signaling CRMPs in Sema3A signaling Other semaphorin interactions RHOD GTPase cycle RND1 GTPase cycle	G alpha (12/13) signalling events Sema4D mediated inhibition of cell attachment and migration Sema4D induced cell migration and growth-cone collapse RHOD GTPase cycle
Drugs
Diseases
GWAS		Alcoholic chronic pancreatitis ( 28754779) Blood protein levels ( 30072576) Platelet count ( 32888494) Refractive error ( 32231278) Systolic blood pressure ( 31469255) Weight ( 28552196) Whole-brain volume ( 21116278)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Estimated glomerular filtration rate ( 31152163) Inflammatory bowel disease ( 28067908) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)
Interacting Genes		10 interacting genes: AKT1 FES L1CAM NRP1 NRP2 PLXNB1 RAC1 RHOD RND1 SEMA6D	15 interacting genes: ARHGEF11 ARHGEF12 KMT2A L1CAM MECOM MET NRP1 NRP2 PLXNA1 RAC1 RND1 RND3 SEMA4B SEMA4D SOX4
Entrez ID		5361	5364
HPRD ID		11868	03032
Ensembl ID		ENSG00000114554	ENSG00000164050
Uniprot IDs		Q9UIW2	O43157
PDB IDs		7Y4P 7Y4Q	2JPH 2OS6 2R2O 2REX 3HM6 3OL2 3SU8 3SUA 5B4W 7VF3 7VG7 8B3K
Enriched GO Terms of Interacting Partners?		Semaphorin-plexin Signaling Pathway Regulation Of Cellular Component Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Regulation Of Locomotion Positive Regulation Of Cell Projection Organization Regulation Of Cell Motility Locomotion Chemotaxis Cell Projection Organization Semaphorin Receptor Activity Semaphorin Receptor Complex Regulation Of Neuron Projection Development Regulation Of Cell Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Neuron Projection Guidance Axon Guidance Regulation Of Cell Development Anatomical Structure Arrangement Regulation Of Anatomical Structure Morphogenesis Cell Migration Regulation Of Cytoskeleton Organization Vestibulocochlear Nerve Structural Organization Dorsal Root Ganglion Morphogenesis Sensory Neuron Axon Guidance Facioacoustic Ganglion Development Plasma Membrane Positive Regulation Of Cell Migration Regulation Of Cell Migration Motor Neuron Axon Guidance Regulation Of Cell Differentiation Positive Regulation Of Cell Motility Outflow Tract Septum Morphogenesis Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Locomotion Cell Motility Regulation Of Developmental Growth Ameboidal-type Cell Migration Ventral Trunk Neural Crest Cell Migration Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Axonogenesis Regulation Of Organelle Organization Sympathetic Neuron Projection Guidance Trigeminal Ganglion Development Positive Regulation Of Developmental Growth Cranial Ganglion Development Trunk Neural Crest Cell Migration Cell Surface Receptor Signaling Pathway Positive Regulation Of Developmental Process Regulation Of Nervous System Development	Semaphorin-plexin Signaling Pathway Neuron Projection Guidance Semaphorin Receptor Activity Semaphorin Receptor Complex Chemotaxis Locomotion Gonadotrophin-releasing Hormone Neuronal Migration To The Hypothalamus Axon Guidance Hepatocyte Growth Factor Receptor Signaling Pathway Hypothalamus Cell Migration Neuron Projection Development Neural Crest Cell Migration Regulation Of Small GTPase Mediated Signal Transduction Mesenchymal Cell Migration Anatomical Structure Arrangement Vestibulocochlear Nerve Structural Organization Dorsal Root Ganglion Morphogenesis Sensory Neuron Axon Guidance Facioacoustic Ganglion Development Regulation Of Rho Protein Signal Transduction Motor Neuron Axon Guidance Cellular Developmental Process Ventral Trunk Neural Crest Cell Migration Small GTPase-mediated Signal Transduction Positive Regulation Of Endothelial Cell Migration Cell Differentiation Plasma Membrane Bounded Cell Projection Organization Dichotomous Subdivision Of Terminal Units Involved In Salivary Gland Branching Sympathetic Neuron Projection Guidance Ameboidal-type Cell Migration Trigeminal Ganglion Development Cell Migration Positive Regulation Of Cell Migration Nervous System Development Regulation Of Cellular Component Organization Positive Regulation Of Cell Motility Negative Chemotaxis Neuron Migration Positive Regulation Of Locomotion Cranial Ganglion Development Trunk Neural Crest Cell Migration Regulation Of Actin Cytoskeleton Organization Regulation Of Cell Migration Trigeminal Nerve Structural Organization Neural Crest Cell Migration Involved In Autonomic Nervous System Development Sympathetic Neuron Projection Extension Regulation Of Cell Motility Regulation Of Actin Filament-based Process Cell Motility Regulation Of Locomotion
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