SEMA3C and NRP2

Number of citations of the paper that reports this interaction (PubMedID 9331348)
0

Data Source:
HPRD (in vivo)

		SEMA3C	NRP2
Description		semaphorin 3C	neuropilin 2
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Extracellular Exosome	Semaphorin Receptor Complex Extracellular Region Plasma Membrane Membrane Axon Postsynaptic Membrane Glutamatergic Synapse
	Molecular Function	Protein Binding Semaphorin Receptor Binding Neuropilin Binding Chemorepellent Activity	Vascular Endothelial Growth Factor Receptor Activity Protein Binding Heparin Binding Semaphorin Receptor Activity Growth Factor Binding Cytokine Binding Signaling Receptor Activity Identical Protein Binding Metal Ion Binding
	Biological Process	Neural Crest Cell Migration Somitogenesis Blood Vessel Remodeling Outflow Tract Septum Morphogenesis Outflow Tract Morphogenesis Cardiac Right Ventricle Morphogenesis Pulmonary Myocardium Development Immune Response Nervous System Development Axon Guidance Heart Development Response To Xenobiotic Stimulus Post-embryonic Development Neural Tube Development Cell Differentiation Positive Regulation Of Cell Migration Negative Chemotaxis Limb Bud Formation Dichotomous Subdivision Of Terminal Units Involved In Salivary Gland Branching Semaphorin-plexin Signaling Pathway Cardiac Endothelial To Mesenchymal Transition Positive Regulation Of Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis	Angiogenesis Neuron Migration Positive Regulation Of Endothelial Cell Proliferation Outflow Tract Septum Morphogenesis Cell Adhesion Nervous System Development Axon Guidance Heart Development Positive Regulation Of Endothelial Cell Migration Facial Nerve Structural Organization Trigeminal Nerve Structural Organization Vestibulocochlear Nerve Structural Organization Nerve Development Branchiomotor Neuron Axon Guidance Gonadotrophin-releasing Hormone Neuronal Migration To The Hypothalamus Cell Differentiation Trunk Neural Crest Cell Migration Ventral Trunk Neural Crest Cell Migration Vascular Endothelial Growth Factor Signaling Pathway Axon Extension Involved In Axon Guidance Negative Chemotaxis Sympathetic Ganglion Development Trigeminal Ganglion Development Semaphorin-plexin Signaling Pathway Sensory Neuron Axon Guidance Sympathetic Neuron Projection Extension Sympathetic Neuron Projection Guidance Regulation Of Postsynapse Organization Neural Crest Cell Migration Involved In Autonomic Nervous System Development Facioacoustic Ganglion Development Dorsal Root Ganglion Morphogenesis Cellular Response To Leukemia Inhibitory Factor
Pathways			Neurophilin interactions with VEGF and VEGFR NrCAM interactions
Drugs			ATYR1923
Diseases
GWAS		Bilirubin levels ( 19414484) Blood protein levels ( 30072576) CSF tryptophan concentration in tuberculous meningitis ( 29395996) Diastolic blood pressure ( 27841878) Glaucoma ( 31959993 30054594) Glaucoma (primary open-angle) ( 29891935 33627673) Glucocorticoid-induced osteonecrosis (age 10 years and older) ( 26265699) HDL cholesterol ( 27036123) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) High density lipoprotein cholesterol levels ( 29403010 33339817) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Intraocular pressure ( 29617998 29235454 30054594 31959993) Metabolite levels ( 23823483) Posterior cortical atrophy and Alzheimer's disease ( 26993346) Red blood cell count ( 32888494) Resistance to antihypertensive treatment in hypertension ( 31545351) Rosacea symptom severity ( 29771307) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Blood protein levels ( 30072576) Craniofacial microsomia ( 26853712) Daytime nap ( 33568662) Diisocyanate-induced asthma ( 25918132) Neuropathy x type 2 diabetes interaction ( 32541925)
Interacting Genes		2 interacting genes: NRP1 NRP2	11 interacting genes: FLT1 L1CAM NRP1 PGF PLXNA1 PLXNB1 SEMA3B SEMA3C SEMA3F SEMA4F VEGFA
Entrez ID		10512	8828
HPRD ID		04034	03643
Ensembl ID		ENSG00000075223	ENSG00000118257
Uniprot IDs		Q99985	O60462
PDB IDs			2QQJ 2QQK 2QQL 2QQO 4QDQ 4QDR 4QDS 5DN2 5DQ0 6GH8 6TDB 6TJT 7M22 7T4S 8IVW 8IVX
Enriched GO Terms of Interacting Partners?		Vestibulocochlear Nerve Structural Organization Dorsal Root Ganglion Morphogenesis Sensory Neuron Axon Guidance Facioacoustic Ganglion Development Ventral Trunk Neural Crest Cell Migration Sympathetic Neuron Projection Guidance Trigeminal Ganglion Development Cranial Ganglion Development Trigeminal Nerve Structural Organization Neural Crest Cell Migration Involved In Autonomic Nervous System Development Gonadotrophin-releasing Hormone Neuronal Migration To The Hypothalamus Trunk Neural Crest Cell Migration Sympathetic Neuron Projection Extension Vascular Endothelial Growth Factor Receptor Activity Branchiomotor Neuron Axon Guidance Hypothalamus Cell Migration Facial Nerve Structural Organization Sympathetic Ganglion Development Axon Extension Involved In Axon Guidance Semaphorin Receptor Activity Semaphorin Receptor Complex Ganglion Development Anatomical Structure Arrangement Vascular Endothelial Growth Factor Signaling Pathway Motor Neuron Axon Guidance Outflow Tract Septum Morphogenesis Cytokine Binding Semaphorin-plexin Signaling Pathway Growth Factor Binding Axon Extension Neural Crest Cell Migration Mesenchymal Cell Migration Cardiac Septum Morphogenesis Neuron Projection Extension Positive Regulation Of Endothelial Cell Proliferation Developmental Cell Growth Positive Regulation Of Endothelial Cell Migration Ameboidal-type Cell Migration Otic Placode Development Basal Dendrite Development Developmental Growth Involved In Morphogenesis Neuron Migration Regulation Of Endothelial Cell Proliferation Heparin Binding Renal Artery Morphogenesis VEGF-activated Neuropilin Signaling Pathway Trigeminal Nerve Morphogenesis Endothelial Tip Cell Fate Specification Regulation Of Endothelial Cell Migration Positive Regulation Of Epithelial Cell Proliferation	Semaphorin-plexin Signaling Pathway Chemotaxis Locomotion Neuron Projection Guidance Neuropilin Binding Semaphorin Receptor Binding Cell Migration Regulation Of Cell Migration Regulation Of Cell Motility Cell Motility Regulation Of Locomotion Axon Guidance Neuron Projection Development Neural Crest Cell Migration Regulation Of Axonogenesis Mesenchymal Cell Migration Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Vascular Endothelial Growth Factor Signaling Pathway Cell Projection Organization Dichotomous Subdivision Of Terminal Units Involved In Salivary Gland Branching Regulation Of Axon Extension Chemorepellent Activity Cell Surface Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Sprouting Angiogenesis Plasma Membrane Bounded Cell Projection Organization Negative Chemotaxis Ameboidal-type Cell Migration Regulation Of Neurogenesis Semaphorin Receptor Activity Semaphorin Receptor Complex Regulation Of Neuron Projection Development Regulation Of Nervous System Development Regulation Of Axon Extension Involved In Axon Guidance Positive Regulation Of Axonogenesis Regulation Of Anatomical Structure Morphogenesis Retinal Ganglion Cell Axon Guidance VEGF-activated Neuropilin Signaling Pathway Cellular Response To Vascular Endothelial Growth Factor Stimulus Regulation Of Developmental Growth Negative Regulation Of Axon Extension Ventral Trunk Neural Crest Cell Migration Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Positive Regulation Of Axon Extension Vascular Endothelial Growth Factor Receptor Binding Sympathetic Neuron Projection Guidance Neuropilin Signaling Pathway
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