SEMA3C and NRP1

Number of citations of the paper that reports this interaction (PubMedID 9331348)
0

Data Source:
HPRD (in vivo)

		SEMA3C	NRP1
Description		semaphorin 3C	neuropilin 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Extracellular Exosome	Semaphorin Receptor Complex Extracellular Region Extracellular Space Cytoplasm Mitochondrion Early Endosome Cytosol Neurofilament Plasma Membrane Focal Adhesion Membrane Axon Cytoplasmic Vesicle Mitochondrial Membrane Neuron Projection Receptor Complex Postsynaptic Membrane Sorting Endosome Glutamatergic Synapse
	Molecular Function	Protein Binding Semaphorin Receptor Binding Neuropilin Binding Chemorepellent Activity	Vascular Endothelial Growth Factor Receptor Activity GTPase Activator Activity Protein Binding Heparin Binding Coreceptor Activity Semaphorin Receptor Activity Growth Factor Binding Protein Kinase Binding Cytokine Binding Vascular Endothelial Growth Factor Binding Metal Ion Binding
	Biological Process	Neural Crest Cell Migration Somitogenesis Blood Vessel Remodeling Outflow Tract Septum Morphogenesis Outflow Tract Morphogenesis Cardiac Right Ventricle Morphogenesis Pulmonary Myocardium Development Immune Response Nervous System Development Axon Guidance Heart Development Response To Xenobiotic Stimulus Post-embryonic Development Neural Tube Development Cell Differentiation Positive Regulation Of Cell Migration Negative Chemotaxis Limb Bud Formation Dichotomous Subdivision Of Terminal Units Involved In Salivary Gland Branching Semaphorin-plexin Signaling Pathway Cardiac Endothelial To Mesenchymal Transition Positive Regulation Of Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis	Angiogenesis Branching Involved In Blood Vessel Morphogenesis Vasculogenesis Neural Crest Cell Migration Neuron Migration Positive Regulation Of Endothelial Cell Proliferation Sprouting Angiogenesis Cell Migration Involved In Sprouting Angiogenesis Outflow Tract Septum Morphogenesis Substrate-dependent Cell Migration, Cell Extension Signal Transduction Integrin-mediated Signaling Pathway Cell-cell Signaling Nervous System Development Axon Guidance Axonal Fasciculation Heart Development Motor Neuron Axon Guidance Response To Wounding Animal Organ Morphogenesis Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Smooth Muscle Cell Migration Dendrite Development Facial Nerve Structural Organization Trigeminal Nerve Morphogenesis Trigeminal Nerve Structural Organization Vestibulocochlear Nerve Structural Organization Branchiomotor Neuron Axon Guidance Gonadotrophin-releasing Hormone Neuronal Migration To The Hypothalamus Cell Differentiation Negative Regulation Of Axon Extension Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Retinal Ganglion Cell Axon Guidance Regulation Of Cdc42 Protein Signal Transduction Cellular Response To Hepatocyte Growth Factor Stimulus Endothelial Cell Chemotaxis Cellular Response To Vascular Endothelial Growth Factor Stimulus Ventral Trunk Neural Crest Cell Migration Vascular Endothelial Growth Factor Signaling Pathway Neuropilin Signaling Pathway VEGF-activated Neuropilin Signaling Pathway Positive Regulation Of Phosphorylation Negative Regulation Of Neuron Apoptotic Process Blood Vessel Endothelial Cell Migration Endothelial Cell Migration Positive Regulation Of Angiogenesis Symbiont Entry Into Host Cell Platelet-derived Growth Factor Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Hepatocyte Growth Factor Receptor Signaling Pathway Sympathetic Nervous System Development Neuron Development Axon Extension Regulation Of Axon Extension Involved In Axon Guidance Positive Regulation Of Axon Extension Involved In Axon Guidance Negative Regulation Of Axon Extension Involved In Axon Guidance Artery Morphogenesis Axon Extension Involved In Axon Guidance Positive Chemotaxis Positive Regulation Of Filopodium Assembly Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Axonogenesis Involved In Innervation Regulation Of Vesicle-mediated Transport Dichotomous Subdivision Of Terminal Units Involved In Salivary Gland Branching Angiogenesis Involved In Coronary Vascular Morphogenesis Coronary Artery Morphogenesis Retina Vasculature Development In Camera-type Eye Retina Vasculature Morphogenesis In Camera-type Eye Renal Artery Morphogenesis Sympathetic Ganglion Development Trigeminal Ganglion Development Positive Regulation Of ERK1 And ERK2 Cascade Semaphorin-plexin Signaling Pathway Commissural Neuron Axon Guidance Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Endothelial Tip Cell Fate Specification Sensory Neuron Axon Guidance Motor Neuron Migration Sympathetic Neuron Projection Extension Sympathetic Neuron Projection Guidance Postsynapse Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Basal Dendrite Development Basal Dendrite Arborization Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Neural Crest Cell Migration Involved In Autonomic Nervous System Development Protein Localization To Early Endosome Facioacoustic Ganglion Development Dorsal Root Ganglion Morphogenesis Otic Placode Development Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways			Neurophilin interactions with VEGF and VEGFR Signaling by ROBO receptors Sema3A PAK dependent Axon repulsion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion CRMPs in Sema3A signaling CRMPs in Sema3A signaling Signal transduction by L1 CHL1 interactions Attachment and Entry
Drugs
Diseases
GWAS		Bilirubin levels ( 19414484) Blood protein levels ( 30072576) CSF tryptophan concentration in tuberculous meningitis ( 29395996) Diastolic blood pressure ( 27841878) Glaucoma ( 31959993 30054594) Glaucoma (primary open-angle) ( 29891935 33627673) Glucocorticoid-induced osteonecrosis (age 10 years and older) ( 26265699) HDL cholesterol ( 27036123) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) High density lipoprotein cholesterol levels ( 29403010 33339817) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Intraocular pressure ( 29617998 29235454 30054594 31959993) Metabolite levels ( 23823483) Posterior cortical atrophy and Alzheimer's disease ( 26993346) Red blood cell count ( 32888494) Resistance to antihypertensive treatment in hypertension ( 31545351) Rosacea symptom severity ( 29771307) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Apolipoprotein A1 levels ( 32203549) Blood protein levels ( 30072576) Brain morphology (MOSTest) ( 32665545) Coronary artery disease ( 29212778) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) HDL cholesterol levels ( 32203549) Migraine ( 27322543) Reticulocyte count ( 32888494) Schizophrenia ( 21682944) Small cell lung carcinoma ( 28604730) Tetralogy of Fallot ( 23297363) Type 1 diabetes ( 34127860) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		2 interacting genes: NRP1 NRP2	27 interacting genes: FGF1 FGF2 FGF4 FGF7 FGFR1 FLT1 GIPC1 KDR L1CAM NRP2 PGF PLXNA1 PLXNB1 RPL27 SEMA3A SEMA3B SEMA3C SEMA3F SNCA SNX5 SNX6 TGFBR1 TGFBR2 TGFBR3 USP9X VEGFA VEGFB
Entrez ID		10512	8829
HPRD ID		04034	03642
Ensembl ID		ENSG00000075223	ENSG00000099250
Uniprot IDs		Q99985	A8K9V7 E9PEP6 O14786 Q59F20 Q6X907
PDB IDs			1KEX 2QQI 2QQM 2QQN 3I97 4DEQ 4RN5 5C7G 5IJR 5IYY 5J1X 5JGI 5JGQ 5JHK 5L73 6FMC 6FMF 6TKK 7JJC 7O1N 7P5U 8C5G 8PFE 9EOU
Enriched GO Terms of Interacting Partners?		Vestibulocochlear Nerve Structural Organization Dorsal Root Ganglion Morphogenesis Sensory Neuron Axon Guidance Facioacoustic Ganglion Development Ventral Trunk Neural Crest Cell Migration Sympathetic Neuron Projection Guidance Trigeminal Ganglion Development Cranial Ganglion Development Trigeminal Nerve Structural Organization Neural Crest Cell Migration Involved In Autonomic Nervous System Development Gonadotrophin-releasing Hormone Neuronal Migration To The Hypothalamus Trunk Neural Crest Cell Migration Sympathetic Neuron Projection Extension Vascular Endothelial Growth Factor Receptor Activity Branchiomotor Neuron Axon Guidance Hypothalamus Cell Migration Facial Nerve Structural Organization Sympathetic Ganglion Development Axon Extension Involved In Axon Guidance Semaphorin Receptor Activity Semaphorin Receptor Complex Ganglion Development Anatomical Structure Arrangement Vascular Endothelial Growth Factor Signaling Pathway Motor Neuron Axon Guidance Outflow Tract Septum Morphogenesis Cytokine Binding Semaphorin-plexin Signaling Pathway Growth Factor Binding Axon Extension Neural Crest Cell Migration Mesenchymal Cell Migration Cardiac Septum Morphogenesis Neuron Projection Extension Positive Regulation Of Endothelial Cell Proliferation Developmental Cell Growth Positive Regulation Of Endothelial Cell Migration Ameboidal-type Cell Migration Otic Placode Development Basal Dendrite Development Developmental Growth Involved In Morphogenesis Neuron Migration Regulation Of Endothelial Cell Proliferation Heparin Binding Renal Artery Morphogenesis VEGF-activated Neuropilin Signaling Pathway Trigeminal Nerve Morphogenesis Endothelial Tip Cell Fate Specification Regulation Of Endothelial Cell Migration Positive Regulation Of Epithelial Cell Proliferation	Regulation Of Locomotion Regulation Of Cell Migration Positive Regulation Of Cell Migration Regulation Of Cell Motility Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Semaphorin-plexin Signaling Pathway Cell Migration Enzyme-linked Receptor Protein Signaling Pathway Heparin Binding Chemotaxis Cell Motility Cell Surface Receptor Signaling Pathway Locomotion Vascular Endothelial Growth Factor Signaling Pathway Tissue Morphogenesis Positive Regulation Of Cell Division Regulation Of Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Proliferation Regulation Of Epithelial Cell Proliferation Anatomical Structure Formation Involved In Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Regulation Of Chemotaxis Neuropilin Binding Angiogenesis Positive Regulation Of Cell Communication Positive Regulation Of Signaling Extracellular Region Positive Regulation Of Cell Population Proliferation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Semaphorin Receptor Binding Lung Development Anatomical Structure Morphogenesis Regulation Of Cell Division Positive Regulation Of Vasculature Development Cellular Response To Growth Factor Stimulus Positive Regulation Of Endothelial Cell Migration Regulation Of Endothelial Cell Migration Positive Regulation Of Phosphate Metabolic Process Chemoattractant Activity Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Response To Growth Factor Developmental Growth Involved In Morphogenesis Neuron Projection Guidance Positive Regulation Of MAPK Cascade Morphogenesis Of An Epithelium Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Cellular Response To Growth Factor Stimulus
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