CDK18 and AK8

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CDK18	AK8
Description		cyclin dependent kinase 18	adenylate kinase 8
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion	Cytoplasm Cytosol Cytoskeleton Axoneme Sperm Flagellum Cell Projection 9+2 Motile Cilium
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Nucleotide Binding AMP Kinase Activity Nucleoside Diphosphate Kinase Activity Protein Binding ATP Binding AMP Binding Kinase Activity Transferase Activity Phosphotransferase Activity, Phosphate Group As Acceptor Nucleobase-containing Compound Kinase Activity DCMP Kinase Activity
	Biological Process	Positive Regulation Of Myelination Regulation Of Cell Cycle Phase Transition	Nucleobase-containing Compound Metabolic Process Nucleotide Metabolic Process Nucleoside Monophosphate Metabolic Process Ventricular System Development Nucleoside Monophosphate Phosphorylation
Pathways			Interconversion of nucleotide di- and triphosphates
Drugs			Bis(Adenosine)-5'-Pentaphosphate
Diseases
GWAS		Coronary artery disease in type 1 diabetes ( 29695241)	Obesity-related traits ( 23251661)
Interacting Genes		55 interacting genes: AK8 APP BLZF1 CBY2 CCDC102B CCDC125 CCDC85B CCDC88B CCND3 CCNDBP1 CCNK CEP76 EYA2 FSD2 GOLGA2 GOLGA6L9 GORASP2 HAP1 HMBOX1 HOMER3 HOOK2 INCA1 KIFC3 KRT15 KRT16 KRT31 KRT34 KRT40 KRT75 KRT86 LZTS2 MAD1L1 MID2 MIPOL1 MTUS2 NUTM1 PIBF1 PNMA1 PPFIA1 RABEP1 REL SEC23A TRAF1 TRAF2 TRIM27 TRIM50 TRIM54 TSGA10 TTC23 VPS28 VPS52 ZNF426 ZNF438 ZNF774 ZRANB1	17 interacting genes: ALKBH3 CCDC102B CDK18 CFTR CNTF DPY30 FBXO7 HAUS1 MAP3K7CL MCM7 MID1IP1 PRMT6 RBM39 SMG9 SYT17 UBE2Z ZMAT2
Entrez ID		5129	158067
HPRD ID		01354	12991
Ensembl ID		ENSG00000117266	ENSG00000165695
Uniprot IDs		Q07002 Q59G02	Q96MA6
PDB IDs
Enriched GO Terms of Interacting Partners?		Cytoskeleton Structural Constituent Of Skin Epidermis Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Supramolecular Fiber Organization Intermediate Filament Cytoskeleton Organization Centrosome Microtubule Protein Binding Microtubule Binding Cytoplasm Structural Molecule Activity Organelle Organization Microtubule-based Process Dynein Light Intermediate Chain Binding Identical Protein Binding Regulation Of Extrinsic Apoptotic Signaling Pathway Cytosol Cellular Localization Thioesterase Binding Cis-Golgi Network Golgi Organization Cyclin-dependent Protein Serine/threonine Kinase Activator Activity
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