IL1RL2 and OTUB1

Number of citations of the paper that reports this interaction (PubMedID 29176319)
36

Data Source:
BioGRID (enzymatic study)

		IL1RL2	OTUB1
Description		interleukin 1 receptor like 2	OTU deubiquitinase, ubiquitin aldehyde binding 1
Image
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane	Nucleoplasm Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Interleukin-1 Receptor Activity Interleukin-1, Type I, Activating Receptor Activity Hydrolase Activity Signaling Receptor Activity NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity DeNEDDylase Activity Ubiquitin Protein Ligase Binding Ubiquitin Binding Ubiquitin-protein Transferase Inhibitor Activity
	Biological Process	Immune System Process Inflammatory Response Cellular Defense Response Signal Transduction Cell Surface Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Positive Regulation Of Interleukin-6 Production Innate Immune Response Positive Regulation Of T Cell Differentiation Regulation Of Inflammatory Response Interleukin-1-mediated Signaling Pathway	Adaptive Immune Response Immune System Process DNA Repair Proteolysis DNA Damage Response Protein Deubiquitination Cellular Response To Nutrient Levels TORC1 Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Deubiquitination Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Negative Regulation Of Double-strand Break Repair
Pathways		Interleukin-38 signaling Interleukin-36 pathway	Ub-specific processing proteases Ovarian tumor domain proteases
Drugs		Spesolimab
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011 29083406) Asthma ( 31959851 31619474 30929738 29273806 27182965) Asthma (adult onset) ( 31036433 30929738) Asthma (childhood onset) ( 31036433 29273806 30929738) Asthma onset (childhood vs adult) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Bisphosphonate-associated atypical femoral fracture ( 31006051) Blood protein levels ( 30072576) Celiac disease ( 20190752) Crohn's disease ( 28067908) Familial squamous cell lung carcinoma ( 29924316) Inflammatory bowel disease ( 28067908 23128233) Primary biliary cholangitis ( 26394269) Self-reported allergy ( 23817569) Serum protein levels (sST2) ( 23999434) Waist circumference ( 23966867)	Bipolar disorder ( 31043756)
Interacting Genes		4 interacting genes: IL18 OTUB1 STAMBP USP2	59 interacting genes: ACVR1 ACVR1B ANXA1 ANXA7 AURKA BIRC2 BMPR1A BMPR1B CCN6 CD274 CDKN1A CEBPA CPEB2 CSNK2A1 ECT2 ESR1 H2AX HSF1 IL1RL2 KDM1A LINC00857 MAPT MSH2 MYC NEDD8 OTUD6B PJA1 RFFL RHOA RNF126 RNF128 SETD7 SMAD2 SMAD3 SMAD4 SMAD9 SNAI1 TGFBR1 TP53 TRAF6 TRIM54 TRIM55 TRIM63 TSC22D1 TTR UBA6 UBC UBD UBE2D2 UBE2D3 UBE2D4 UBE2E2 UBE2S UBE2Z UBE4B USP15 USP21 USP28 YAP1
Entrez ID		8808	55611
HPRD ID		05150	08493
Ensembl ID		ENSG00000115598	ENSG00000167770
Uniprot IDs		Q9HB29	B3KUV5 Q96FW1
PDB IDs		6U6U 9ETH 9ETI	2ZFY 3VON 4DDG 4DDI 4DHZ 4I6L 4LDT
Enriched GO Terms of Interacting Partners?		Protein Deubiquitination Protein Modification By Small Protein Removal Peptidase Activity Regulation Of Intracellular Signal Transduction Cysteine-type Deubiquitinase Activity Interleukin-18 Receptor Binding Cysteine-type Peptidase Activity Post-translational Protein Modification Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell Communication Regulation Of Signal Transduction Adaptive Immune Response Positive Regulation Of NK T Cell Proliferation Positive Regulation Of T-helper 2 Cell Differentiation Sleep Regulation Of Signaling Positive Regulation Of T-helper 1 Cell Cytokine Production Ubiquitin Protein Ligase Binding Proteolysis Regulation Of Hippocampal Neuron Apoptotic Process Negative Regulation Of Hippocampal Neuron Apoptotic Process Hippocampal Neuron Apoptotic Process Ubiquitin-protein Transferase Inhibitor Activity DeNEDDylase Activity Positive Regulation Of NK T Cell Activation T-helper 1 Type Immune Response Type 2 Immune Response Interleukin-18-mediated Signaling Pathway Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Natural Killer Cell Proliferation Regulation Of Natural Killer Cell Proliferation Protein Modification Process Locomotor Rhythm Hydrolase Activity Metal-dependent Deubiquitinase Activity Positive Regulation Of Interleukin-13 Production Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production K63-linked Deubiquitinase Activity Positive Regulation Of Type 2 Immune Response Positive Regulation Of T-helper 1 Type Immune Response Positive Regulation Of Activated T Cell Proliferation Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Neuroinflammatory Response Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Interleukin-17 Production Positive Regulation Of Natural Killer Cell Activation Positive Regulation Of Tissue Remodeling Negative Regulation Of Myoblast Differentiation Positive Regulation Of T-helper Cell Differentiation	Post-translational Protein Modification Protein Modification Process Regulation Of Programmed Cell Death Protein Ubiquitination Regulation Of Apoptotic Process Protein Metabolic Process Protein Modification By Small Protein Conjugation Macromolecule Metabolic Process Positive Regulation Of Cell Differentiation Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process SMAD Binding Modification-dependent Protein Catabolic Process I-SMAD Binding Regulation Of Cell Differentiation Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Positive Regulation Of Developmental Process In Utero Embryonic Development Negative Regulation Of Apoptotic Process Ubiquitin-dependent Protein Catabolic Process Chordate Embryonic Development Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Gene Expression Negative Regulation Of Programmed Cell Death Proteolysis Involved In Protein Catabolic Process Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Response To Stress Protein Polyubiquitination Proteolysis Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Transmembrane Receptor Protein Serine/threonine Kinase Activity Nucleus Positive Regulation Of Nucleobase-containing Compound Metabolic Process Transforming Growth Factor Beta Receptor Activity, Type I Activin Receptor Signaling Pathway Response To Growth Factor Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Negative Regulation Of Metabolic Process Macromolecule Catabolic Process Regulation Of Gene Expression Regulation Of Developmental Process Ubiquitin Conjugating Enzyme Activity Response To Ionizing Radiation Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Macromolecule Biosynthetic Process
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