IL1RL2 and IL18

Number of citations of the paper that reports this interaction (PubMedID 9325300)
0

Data Source:
HPRD (in vitro, in vivo)

		IL1RL2	IL18
Description		interleukin 1 receptor like 2	interleukin 18
Image
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane	Extracellular Region Extracellular Space Cytoplasm Cytosol
	Molecular Function	Interleukin-1 Receptor Activity Interleukin-1, Type I, Activating Receptor Activity Hydrolase Activity Signaling Receptor Activity NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating	Cytokine Activity Protein Binding Interleukin-18 Receptor Binding Receptor Ligand Activity
	Biological Process	Immune System Process Inflammatory Response Cellular Defense Response Signal Transduction Cell Surface Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Positive Regulation Of Interleukin-6 Production Innate Immune Response Positive Regulation Of T Cell Differentiation Regulation Of Inflammatory Response Interleukin-1-mediated Signaling Pathway	Angiogenesis Inflammatory Response Immune Response Cell Surface Receptor Signaling Pathway Cell-cell Signaling Cell Population Proliferation Positive Regulation Of Gene Expression Positive Regulation Of Macrophage Derived Foam Cell Differentiation Cytokine-mediated Signaling Pathway Natural Killer Cell Activation Regulation Of Cell Adhesion Sleep Positive Regulation Of Chemokine Production Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-13 Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Tissue Remodeling Interleukin-18-mediated Signaling Pathway T-helper 1 Type Immune Response Type 2 Immune Response Positive Regulation Of Activated T Cell Proliferation Neutrophil Activation Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Cholesterol Homeostasis Positive Regulation Of T-helper 2 Cell Differentiation Negative Regulation Of Myoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Inflammatory Response Defense Response To Gram-positive Bacterium Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of NK T Cell Proliferation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Establishment Of Skin Barrier Triglyceride Homeostasis Cellular Response To Lipopolysaccharide Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Neuroinflammatory Response Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of T-helper 1 Cell Cytokine Production
Pathways		Interleukin-38 signaling Interleukin-36 pathway	Interleukin-1 processing Pyroptosis Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Interleukin-18 signaling Purinergic signaling in leishmaniasis infection CASP4-mediated substrate cleavage CASP5-mediated substrate cleavage
Drugs		Spesolimab
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011 29083406) Asthma ( 31959851 31619474 30929738 29273806 27182965) Asthma (adult onset) ( 31036433 30929738) Asthma (childhood onset) ( 31036433 29273806 30929738) Asthma onset (childhood vs adult) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Bisphosphonate-associated atypical femoral fracture ( 31006051) Blood protein levels ( 30072576) Celiac disease ( 20190752) Crohn's disease ( 28067908) Familial squamous cell lung carcinoma ( 29924316) Inflammatory bowel disease ( 28067908 23128233) Primary biliary cholangitis ( 26394269) Self-reported allergy ( 23817569) Serum protein levels (sST2) ( 23999434) Waist circumference ( 23966867)	Blood protein levels in cardiovascular risk ( 28369058) Inflammatory biomarkers ( 24182552) Interleukin-18 levels ( 27989323 31584380) Protein quantitative trait loci ( 18464913)
Interacting Genes		4 interacting genes: IL18 OTUB1 STAMBP USP2	9 interacting genes: ADIRF CASK CASP1 CASP3 CASP4 IL18BP IL18R1 IL18RAP IL1RL2
Entrez ID		8808	3606
HPRD ID		05150	02976
Ensembl ID		ENSG00000115598	ENSG00000150782
Uniprot IDs		Q9HB29	Q14116
PDB IDs		6U6U 9ETH 9ETI	1J0S 2VXT 3F62 3WO2 3WO3 3WO4 4EEE 4EKX 4HJJ 4R6U 4XFS 4XFT 4XFU 7AL7 8J6K 8SPB 8SV1 8URV
Enriched GO Terms of Interacting Partners?		Protein Deubiquitination Protein Modification By Small Protein Removal Peptidase Activity Regulation Of Intracellular Signal Transduction Cysteine-type Deubiquitinase Activity Interleukin-18 Receptor Binding Cysteine-type Peptidase Activity Post-translational Protein Modification Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell Communication Regulation Of Signal Transduction Adaptive Immune Response Positive Regulation Of NK T Cell Proliferation Positive Regulation Of T-helper 2 Cell Differentiation Sleep Regulation Of Signaling Positive Regulation Of T-helper 1 Cell Cytokine Production Ubiquitin Protein Ligase Binding Proteolysis Regulation Of Hippocampal Neuron Apoptotic Process Negative Regulation Of Hippocampal Neuron Apoptotic Process Hippocampal Neuron Apoptotic Process Ubiquitin-protein Transferase Inhibitor Activity DeNEDDylase Activity Positive Regulation Of NK T Cell Activation T-helper 1 Type Immune Response Type 2 Immune Response Interleukin-18-mediated Signaling Pathway Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Natural Killer Cell Proliferation Regulation Of Natural Killer Cell Proliferation Protein Modification Process Locomotor Rhythm Hydrolase Activity Metal-dependent Deubiquitinase Activity Positive Regulation Of Interleukin-13 Production Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production K63-linked Deubiquitinase Activity Positive Regulation Of Type 2 Immune Response Positive Regulation Of T-helper 1 Type Immune Response Positive Regulation Of Activated T Cell Proliferation Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Neuroinflammatory Response Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Interleukin-17 Production Positive Regulation Of Natural Killer Cell Activation Positive Regulation Of Tissue Remodeling Negative Regulation Of Myoblast Differentiation Positive Regulation Of T-helper Cell Differentiation	Interleukin-18-mediated Signaling Pathway Cytokine-mediated Signaling Pathway NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating Inflammatory Response Interleukin-18 Receptor Complex Interleukin-18 Receptor Activity Interleukin-18 Binding Pyroptotic Inflammatory Response NLRP1 Inflammasome Complex Interleukin-1 Receptor Activity Cysteine-type Endopeptidase Activity Immune System Process Cellular Response To Chemical Stress Defense Response Response To Hydrogen Peroxide Canonical Inflammasome Complex Regulation Of Defense Response CARD Domain Binding Pyroptotic Cell Death Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Cysteine-type Peptidase Activity Protein Poly-ADP-ribosylation Regulation Of Inflammatory Response Hydrolase Activity Protein Autoprocessing Positive Regulation Of Defense Response Response To Reactive Oxygen Species Positive Regulation Of Inflammatory Response Interleukin-1-mediated Signaling Pathway Protein Processing Response To Cytokine Response To Peptide Cell Surface Receptor Signaling Pathway Immune Response Response To Stress Response To External Biotic Stimulus Cellular Response To Osmotic Stress Signaling Receptor Activity Adaptive Immune Response Response To Lipopolysaccharide Protein Maturation Positive Regulation Of Cytokine-mediated Signaling Pathway Regulation Of Cytokine Production Response To Molecule Of Bacterial Origin Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Response To Cytokine Stimulus Positive Regulation Of Neuron Apoptotic Process Non-canonical Inflammasome Complex Cellular Response To Interleukin-18 Cellular Response To Hydrogen Peroxide
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