IL1RL2 and STAMBP

Number of citations of the paper that reports this interaction (PubMedID 29176319)
36

Data Source:
BioGRID (enzymatic study)

		IL1RL2	STAMBP
Description		interleukin 1 receptor like 2	STAM binding protein
Image
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane	Nucleus Nucleoplasm Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Membrane Cleavage Furrow Extracellular Exosome
	Molecular Function	Interleukin-1 Receptor Activity Interleukin-1, Type I, Activating Receptor Activity Hydrolase Activity Signaling Receptor Activity NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating	Protein Binding Peptidase Activity Metallopeptidase Activity Hydrolase Activity Protein Domain Specific Binding Metal Ion Binding K63-linked Deubiquitinase Activity Deubiquitinase Activity Metal-dependent Deubiquitinase Activity
	Biological Process	Immune System Process Inflammatory Response Cellular Defense Response Signal Transduction Cell Surface Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Positive Regulation Of Interleukin-6 Production Innate Immune Response Positive Regulation Of T Cell Differentiation Regulation Of Inflammatory Response Interleukin-1-mediated Signaling Pathway	Mitotic Cytokinesis Proteolysis Cell Surface Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Cell Population Proliferation Protein Deubiquitination Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein K63-linked Deubiquitination Hippocampal Neuron Apoptotic Process Negative Regulation Of Hippocampal Neuron Apoptotic Process
Pathways		Interleukin-38 signaling Interleukin-36 pathway	Metalloprotease DUBs
Drugs		Spesolimab
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011 29083406) Asthma ( 31959851 31619474 30929738 29273806 27182965) Asthma (adult onset) ( 31036433 30929738) Asthma (childhood onset) ( 31036433 29273806 30929738) Asthma onset (childhood vs adult) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Bisphosphonate-associated atypical femoral fracture ( 31006051) Blood protein levels ( 30072576) Celiac disease ( 20190752) Crohn's disease ( 28067908) Familial squamous cell lung carcinoma ( 29924316) Inflammatory bowel disease ( 28067908 23128233) Primary biliary cholangitis ( 26394269) Self-reported allergy ( 23817569) Serum protein levels (sST2) ( 23999434) Waist circumference ( 23966867)	Anti-saccade response ( 29064472) Bell's palsy ( 33602968) Blood metabolite levels ( 26401656) Serum metabolite levels ( 23093944 33031748)
Interacting Genes		4 interacting genes: IL18 OTUB1 STAMBP USP2	51 interacting genes: ALAS1 AMN APOBEC3A ATG14 BMPR1B CASR CHMP1A CHMP1B CHMP2A CHMP3 CHMP4A CHMP4B CHMP4C CHMP5 CLTC CTNNBL1 CYP2C9 DSCR9 EGFR EPS15 GRAP2 GRB2 IL1RL2 ITGA5 MAP2K5 MAP3K2 MLKL NLRP7 NTPCR PJA1 RBM11 RECQL5 RNF11 SMAD2 SMAD6 SMAD7 SNCA SPG7 STAM STAM2 TNFRSF1A TP53 TRAF6 TRIP13 UACA UBC UBE2S ULK1 USP21 USP28 VHL
Entrez ID		8808	10617
HPRD ID		05150	05877
Ensembl ID		ENSG00000115598	ENSG00000124356
Uniprot IDs		Q9HB29	A0A140VK54 A0A804HIF8 A0A804HII8 A0A804HJ64 O95630
PDB IDs		6U6U 9ETH 9ETI	2XZE 3RZU 3RZV 5IXF
Enriched GO Terms of Interacting Partners?		Protein Deubiquitination Protein Modification By Small Protein Removal Peptidase Activity Regulation Of Intracellular Signal Transduction Cysteine-type Deubiquitinase Activity Interleukin-18 Receptor Binding Cysteine-type Peptidase Activity Post-translational Protein Modification Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell Communication Regulation Of Signal Transduction Adaptive Immune Response Positive Regulation Of NK T Cell Proliferation Positive Regulation Of T-helper 2 Cell Differentiation Sleep Regulation Of Signaling Positive Regulation Of T-helper 1 Cell Cytokine Production Ubiquitin Protein Ligase Binding Proteolysis Regulation Of Hippocampal Neuron Apoptotic Process Negative Regulation Of Hippocampal Neuron Apoptotic Process Hippocampal Neuron Apoptotic Process Ubiquitin-protein Transferase Inhibitor Activity DeNEDDylase Activity Positive Regulation Of NK T Cell Activation T-helper 1 Type Immune Response Type 2 Immune Response Interleukin-18-mediated Signaling Pathway Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Natural Killer Cell Proliferation Regulation Of Natural Killer Cell Proliferation Protein Modification Process Locomotor Rhythm Hydrolase Activity Metal-dependent Deubiquitinase Activity Positive Regulation Of Interleukin-13 Production Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production K63-linked Deubiquitinase Activity Positive Regulation Of Type 2 Immune Response Positive Regulation Of T-helper 1 Type Immune Response Positive Regulation Of Activated T Cell Proliferation Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Neuroinflammatory Response Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Interleukin-17 Production Positive Regulation Of Natural Killer Cell Activation Positive Regulation Of Tissue Remodeling Negative Regulation Of Myoblast Differentiation Positive Regulation Of T-helper Cell Differentiation	ESCRT III Complex Amphisome Membrane Vesicle Fusion With Vacuole Multivesicular Body Organization Multivesicular Body Assembly Multivesicular Body-lysosome Fusion Viral Budding From Plasma Membrane Late Endosome To Vacuole Transport Lysosomal Membrane Organization Endosome Transport Via Multivesicular Body Sorting Pathway Membrane Fission Multivesicular Body Sorting Pathway Late Endosome To Lysosome Transport Kinetochore Microtubule Autophagosome Membrane Viral Budding Via Host ESCRT Complex Regulation Of Mitotic Spindle Assembly Midbody Abscission Regulation Of Mitotic Spindle Organization Viral Budding Nuclear Membrane Reassembly Mitotic Cytokinetic Process Multivesicular Body Membrane Viral Release From Host Cell Plasma Membrane Repair Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Autophagosome Maturation Endosome Organization Regulation Of Spindle Assembly Autophagy Cytokinetic Process Protein-containing Complex Disassembly Endosomal Transport Multivesicular Body Mitotic Metaphase Chromosome Alignment Biological Process Involved In Interaction With Host Nuclear Membrane Organization Vacuolar Transport Vacuole Organization Metaphase Chromosome Alignment Membrane Assembly Endosome Macroautophagy Regulation Of Microtubule Cytoskeleton Organization Chromosome Localization Lysosomal Transport Regulation Of Centrosome Duplication Nuclear Pore Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Nucleus Organization
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?