IL1RL2

Description		interleukin 1 receptor like 2
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GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane
	Molecular Function	Interleukin-1 Receptor Activity Interleukin-1, Type I, Activating Receptor Activity Hydrolase Activity Signaling Receptor Activity NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating
	Biological Process	Immune System Process Inflammatory Response Cellular Defense Response Signal Transduction Cell Surface Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Positive Regulation Of Interleukin-6 Production Innate Immune Response Positive Regulation Of T Cell Differentiation Regulation Of Inflammatory Response Interleukin-1-mediated Signaling Pathway
Pathways		Interleukin-38 signaling Interleukin-36 pathway
Drugs		Spesolimab
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011 29083406) Asthma ( 31959851 31619474 30929738 29273806 27182965) Asthma (adult onset) ( 31036433 30929738) Asthma (childhood onset) ( 31036433 29273806 30929738) Asthma onset (childhood vs adult) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Bisphosphonate-associated atypical femoral fracture ( 31006051) Blood protein levels ( 30072576) Celiac disease ( 20190752) Crohn's disease ( 28067908) Familial squamous cell lung carcinoma ( 29924316) Inflammatory bowel disease ( 28067908 23128233) Primary biliary cholangitis ( 26394269) Self-reported allergy ( 23817569) Serum protein levels (sST2) ( 23999434) Waist circumference ( 23966867)
Interacting Genes		4 interacting genes: IL18 OTUB1 STAMBP USP2
Entrez ID		8808
HPRD ID		05150
Ensembl ID		ENSG00000115598
Uniprot IDs		Q9HB29
PDB IDs		6U6U 9ETH 9ETI
Enriched GO Terms of Interacting Partners?		Protein Deubiquitination Protein Modification By Small Protein Removal Peptidase Activity Regulation Of Intracellular Signal Transduction Cysteine-type Deubiquitinase Activity Interleukin-18 Receptor Binding Cysteine-type Peptidase Activity Post-translational Protein Modification Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell Communication Regulation Of Signal Transduction Adaptive Immune Response Positive Regulation Of NK T Cell Proliferation Positive Regulation Of T-helper 2 Cell Differentiation Sleep Regulation Of Signaling Positive Regulation Of T-helper 1 Cell Cytokine Production Ubiquitin Protein Ligase Binding Proteolysis Regulation Of Hippocampal Neuron Apoptotic Process Negative Regulation Of Hippocampal Neuron Apoptotic Process Hippocampal Neuron Apoptotic Process Ubiquitin-protein Transferase Inhibitor Activity DeNEDDylase Activity Positive Regulation Of NK T Cell Activation T-helper 1 Type Immune Response Type 2 Immune Response Interleukin-18-mediated Signaling Pathway Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Natural Killer Cell Proliferation Regulation Of Natural Killer Cell Proliferation Protein Modification Process Locomotor Rhythm Hydrolase Activity Metal-dependent Deubiquitinase Activity Positive Regulation Of Interleukin-13 Production Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production K63-linked Deubiquitinase Activity Positive Regulation Of Type 2 Immune Response Positive Regulation Of T-helper 1 Type Immune Response Positive Regulation Of Activated T Cell Proliferation Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Neuroinflammatory Response Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Interleukin-17 Production Positive Regulation Of Natural Killer Cell Activation Positive Regulation Of Tissue Remodeling Negative Regulation Of Myoblast Differentiation Positive Regulation Of T-helper Cell Differentiation
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