SUCLG2 and SGCG

Number of citations: 48 (PubMedID 23414517)
Data Source: BioGRID (two hybrid)

		SUCLG2	SGCG
Name		succinate-CoA ligase GDP-forming subunit beta	sarcoglycan gamma
Structure			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Matrix Plasma Membrane Protein-containing Complex Succinate-CoA Ligase Complex Succinate-CoA Ligase Complex (GDP-forming)	Cytoplasm Endoplasmic Reticulum Membrane Cytoskeleton Plasma Membrane Dystroglycan Complex Sarcoglycan Complex Membrane Sarcolemma
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Catalytic Activity Succinate-CoA Ligase (ADP-forming) Activity Succinate-CoA Ligase (GDP-forming) Activity Protein Binding ATP Binding GTP Binding Ligase Activity GDP Binding Protein-containing Complex Binding Metal Ion Binding	Protein Binding
	Biological Process	Tricarboxylic Acid Cycle Succinyl-CoA Metabolic Process Succinate Metabolic Process Succinyl-CoA Catabolic Process	Muscle Organ Development Gene Expression Cardiac Muscle Tissue Development Heart Contraction
Pathways		Citric acid cycle (TCA cycle) Mitochondrial protein degradation	Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)
Drugs		Phenethyl Isothiocyanate	None
Diseases		None	Limb-girdle muscular dystrophy (LGMD) Sarcoglycanopathies, including: Limb-girdle muscular dystrophy (LGMD) 2C; Limb-girdle muscular dystrophy (LGMD) 2D; Limb-girdle muscular dystrophy (LGMD) 2E; Limb-girdle muscular dystrophy (LGMD) 2F
GWAS		Body mass index ( 28552196 ) Cerebrospinal AB1-42 levels in Alzheimer's disease dementia ( 25027320 ) Corneal astigmatism ( 22144915 ) Diabetic kidney disease ( 26305897 ) FEV1 ( 30804560 ) Height ( 20881960 ) Hip circumference ( 28552196 ) IgE levels ( 23146381 ) Lung function (FVC) ( 28166213 30804560 ) Mean corpuscular hemoglobin ( 32888494 ) Mean corpuscular volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Metabolite levels ( 23823483 ) Spontaneous preterm birth with premature rupture of membranes ( 31194736 ) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355 ) Urinary metabolite levels in chronic kidney disease ( 31959995 )	Alanine aminotransferase levels ( 31219225 ) Aspartate aminotransferase levels ( 33547301 ) Asthma ( 27611488 ) Atrial fibrillation ( 30061737 ) Bipolar disorder ( 21738484 ) Central corneal thickness ( 29760442 ) Corneal structure ( 23291589 ) Number of alcoholic drinks required to feel an effect (first five times drinking) ( 31270906 ) Recurrent major depressive disorder x sex interaction ( 34099189 ) Type 2 diabetes ( 23300278 )
Interacting Genes		3 interacting genes: GPR143 SGCG SUCLG1	20 interacting genes: APP CCT6A CLDN5 DNAJB6 DYSF ENO1 ENO3 FLNC HSPA1B MYBPC1 MYBPC2 MYL11 PSAP PYGM SGCB SGCD SPACA1 SSPN SUCLG2 TTN
Entrez ID		8801	6445
HPRD ID		06799	07039
Ensembl ID		ENSG00000172340	ENSG00000102683
Uniprot IDs		Q96I99	Q13326
PDB IDs		6WCV 7MSR 7MSS 7MST 8Z02 8Z03	Not available
GO Terms Enriched among Interactors		Regulation Of Melanosome Organization Regulation Of Melanosome Transport L-tyrosine Binding Eye Pigment Biosynthetic Process L-DOPA Binding L-DOPA Receptor Activity Succinate-CoA Ligase Complex (ADP-forming) Succinate-CoA Ligase Complex (GDP-forming) Succinate-CoA Ligase (GDP-forming) Activity Succinate-CoA Ligase (ADP-forming) Activity Pigment Metabolic Process Involved In Pigmentation Dystroglycan Complex Succinyl-CoA Catabolic Process Dopamine Binding Sarcoglycan Complex Succinyl-CoA Metabolic Process Establishment Of Melanosome Localization Pigment Granule Transport Melanosome Membrane Melanosome Localization Melanosome Transport Heart Contraction Pigment Granule Localization Heart Process Tricarboxylic Acid Cycle Melanosome Organization Pigment Granule Organization Pigment Metabolic Process Cardiac Muscle Tissue Development	M Band Sarcolemma Sarcomere Organization Structural Constituent Of Muscle Actin Filament-based Process Dystrophin-associated Glycoprotein Complex Phosphopyruvate Hydratase Complex Phosphopyruvate Hydratase Activity Muscle Cell Development Actomyosin Structure Organization Cardiac Muscle Cell Development Dystroglycan Complex Actin-mediated Cell Contraction Cardiac Cell Development Sarcoglycan Complex Protein Folding Chaperone Actin Cytoskeleton Organization Actin Filament-based Movement Negative Regulation Of Inclusion Body Assembly Striated Muscle Cell Development Muscle Contraction Actin-myosin Filament Sliding Muscle System Process Extracellular Exosome Canonical Glycolysis Unfolded Protein Binding Glycolytic Process Through Glucose-6-phosphate Glycolytic Process Through Fructose-6-phosphate Carbohydrate Catabolic Process Regulation Of Inclusion Body Assembly Myosin Filament Cell Adhesion Cell Development Nucleoside Phosphate Catabolic Process Glucose Catabolic Process Z Disc Nucleobase-containing Compound Catabolic Process ATP-dependent Protein Folding Chaperone Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of ATP Metabolic Process Positive Regulation Of Toll Signaling Pathway System Process ATP Metabolic Process Organophosphate Catabolic Process Ganglioside GM3 Binding Ganglioside GP1c Binding Positive Regulation Of Beta-galactosidase Activity