SUCLG2 and GPR143

Number of citations of the paper that reports this interaction (PMID 10471510)
28

Data Source:
HPRD (in vitro, in vivo)

		SUCLG2	GPR143
Gene Name		succinate-CoA ligase, GDP-forming, beta subunit	G protein-coupled receptor 143
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Plasma Membrane Succinate-CoA Ligase Complex (GDP-forming)	Cytoplasm Lysosomal Membrane Golgi Apparatus Plasma Membrane Membrane Integral Component Of Membrane Apical Plasma Membrane Melanosome Membrane Melanosome
	Molecular Function	Succinate-CoA Ligase (GDP-forming) Activity ATP Binding GTP Binding GDP Binding Protein Heterodimerization Activity	G-protein Coupled Receptor Activity Protein Binding Dopamine Binding L-DOPA Receptor Activity L-DOPA Binding Tyrosine Binding
	Biological Process	Tricarboxylic Acid Cycle Succinyl-CoA Metabolic Process Succinate Metabolic Process Cellular Metabolic Process Small Molecule Metabolic Process	Eye Pigment Biosynthetic Process Signal Transduction G-protein Coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Visual Perception Melanosome Localization Melanosome Transport Melanosome Organization Calcium-mediated Signaling Using Intracellular Calcium Source Phosphatidylinositol-mediated Signaling Regulation Of Calcium-mediated Signaling
Pathways		Pyruvate metabolism and Citric Acid (TCA) cycle The citric acid (TCA) cycle and respiratory electron transport Citric acid cycle (TCA cycle)
Drugs		Succinic acid
Diseases
GWAS		Corneal astigmatism ( 22144915) Height ( 20881960) IgE levels ( 23146381)	Prostate cancer ( 23535732)
Protein-Protein Interactions		2 interactors: GPR143 SUCLG1	2 interactors: GNAI1 SUCLG2
Entrez ID		8801	4935
HPRD ID		06799	02355
Ensembl ID		ENSG00000172340	ENSG00000101850
Uniprot IDs		E9PDQ8 Q96I99	P51810
PDB IDs
Enriched GO Terms of Interacting Partners?		Eye Pigment Biosynthetic Process Succinyl-CoA Metabolic Process Eye Pigmentation Succinate Metabolic Process Calcium-mediated Signaling Using Intracellular Calcium Source Melanosome Organization Pigment Granule Organization Melanosome Transport Pigment Granule Transport Establishment Of Melanosome Localization Melanosome Localization Tricarboxylic Acid Cycle Regulation Of Calcium-mediated Signaling Citrate Metabolic Process Tricarboxylic Acid Metabolic Process Cellular Pigmentation Pigment Biosynthetic Process Aerobic Respiration Acyl-CoA Metabolic Process Developmental Pigmentation Calcium-mediated Signaling Neuropeptide Signaling Pathway Dicarboxylic Acid Metabolic Process Pigmentation Phosphatidylinositol-mediated Signaling Second-messenger-mediated Signaling Cellular Respiration Visual Perception Sensory Perception Of Light Stimulus Establishment Of Vesicle Localization Vesicle Organization Vesicle Localization	Succinyl-CoA Metabolic Process Succinate Metabolic Process Tricarboxylic Acid Cycle Citrate Metabolic Process Vesicle Fusion Tricarboxylic Acid Metabolic Process Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Aerobic Respiration Acyl-CoA Metabolic Process Organelle Fusion Dicarboxylic Acid Metabolic Process Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Membrane Fusion
Tagcloud ?			abrogation albinism autosomal biosynthesis clue computational confirms create enrichment eye hypopigmentation lab melanin mirna oa oca oca2 ocular oculocutaneous pigmentation reason recessive researches slc45a2 snps tyr tyrp1 utr wet
Tagcloud (Difference) ?			abrogation albinism autosomal biosynthesis clue computational confirms create enrichment eye hypopigmentation lab melanin mirna oa oca oca2 ocular oculocutaneous pigmentation reason recessive researches slc45a2 snps tyr tyrp1 utr wet
Tagcloud (Intersection) ?