SUCLG2 and GPR143

Number of citations of the paper that reports this interaction (PubMedID 10471510)
0

Data Source:
HPRD (in vitro, in vivo)

		SUCLG2	GPR143
Description		succinate-CoA ligase GDP-forming subunit beta	G protein-coupled receptor 143
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Matrix Plasma Membrane Protein-containing Complex Succinate-CoA Ligase Complex Succinate-CoA Ligase Complex (GDP-forming)	Nucleoplasm Cytoplasm Lysosome Lysosomal Membrane Golgi Apparatus Plasma Membrane Membrane Apical Plasma Membrane Nuclear Body Cell Junction Melanosome Membrane Melanosome
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Catalytic Activity Succinate-CoA Ligase (ADP-forming) Activity Succinate-CoA Ligase (GDP-forming) Activity Protein Binding ATP Binding GTP Binding Ligase Activity GDP Binding Protein-containing Complex Binding Metal Ion Binding	G Protein-coupled Receptor Activity Protein Binding Dopamine Binding L-DOPA Receptor Activity L-DOPA Binding L-tyrosine Binding
	Biological Process	Tricarboxylic Acid Cycle Succinyl-CoA Metabolic Process Succinate Metabolic Process Succinyl-CoA Catabolic Process	Eye Pigment Biosynthetic Process Signal Transduction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Visual Perception Melanosome Localization Melanosome Transport Melanosome Organization Regulation Of Melanosome Transport Regulation Of Melanosome Organization
Pathways		Citric acid cycle (TCA cycle) Mitochondrial protein degradation	Amine ligand-binding receptors G alpha (q) signalling events Regulation of MITF-M-dependent genes involved in pigmentation
Drugs		Phenethyl Isothiocyanate
Diseases			Ocular albinism; Ocular albinism, type I (OA1); Waardenburg syndrome, type II (WS2-OA) Congenital motor nystagmus (CMN); Idiopathic congenital nystagmus (ICN)
GWAS		Body mass index ( 28552196) Cerebrospinal AB1-42 levels in Alzheimer's disease dementia ( 25027320) Corneal astigmatism ( 22144915) Diabetic kidney disease ( 26305897) FEV1 ( 30804560) Height ( 20881960) Hip circumference ( 28552196) IgE levels ( 23146381) Lung function (FVC) ( 28166213 30804560) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Spontaneous preterm birth with premature rupture of membranes ( 31194736) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355) Urinary metabolite levels in chronic kidney disease ( 31959995)	Prostate cancer ( 23535732)
Interacting Genes		3 interacting genes: GPR143 SGCG SUCLG1	2 interacting genes: GNAI1 SUCLG2
Entrez ID		8801	4935
HPRD ID		06799	02355
Ensembl ID		ENSG00000172340	ENSG00000101850
Uniprot IDs		Q96I99	P51810
PDB IDs		6WCV 7MSR 7MSS 7MST 8Z02 8Z03
Enriched GO Terms of Interacting Partners?		Regulation Of Melanosome Organization Regulation Of Melanosome Transport L-tyrosine Binding Eye Pigment Biosynthetic Process L-DOPA Binding L-DOPA Receptor Activity Succinate-CoA Ligase Complex (ADP-forming) Succinate-CoA Ligase Complex (GDP-forming) Succinate-CoA Ligase (GDP-forming) Activity Succinate-CoA Ligase (ADP-forming) Activity Pigment Metabolic Process Involved In Pigmentation Dystroglycan Complex Succinyl-CoA Catabolic Process Dopamine Binding Sarcoglycan Complex Succinyl-CoA Metabolic Process Establishment Of Melanosome Localization Pigment Granule Transport Melanosome Membrane Melanosome Localization Melanosome Transport Heart Contraction Pigment Granule Localization Heart Process Tricarboxylic Acid Cycle Melanosome Organization Pigment Granule Organization Pigment Metabolic Process Cardiac Muscle Tissue Development	GDP Binding D2 Dopamine Receptor Binding Magnesium Ion Binding Adenylate Cyclase Inhibitor Activity Positive Regulation Of Relaxation Of Smooth Muscle GTP Binding Adenylate Cyclase Regulator Activity G Protein-coupled Serotonin Receptor Binding Succinate-CoA Ligase (ADP-forming) Activity Succinate-CoA Ligase Complex Succinate-CoA Ligase Complex (GDP-forming) Succinate-CoA Ligase (GDP-forming) Activity Succinyl-CoA Catabolic Process Positive Regulation Of Protein Localization To Cell Cortex Succinate Metabolic Process Regulation Of Protein Localization To Cell Cortex Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Succinyl-CoA Metabolic Process Cellular Response To Forskolin Guanyl Nucleotide Binding Response To Forskolin Regulation Of Relaxation Of Muscle Positive Regulation Of Cholesterol Biosynthetic Process G-protein Beta/gamma-subunit Complex Binding G Protein-coupled Serotonin Receptor Signaling Pathway Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Steroid Biosynthetic Process Response To Prostaglandin E Positive Regulation Of Cholesterol Metabolic Process T Cell Migration Heterotrimeric G-protein Complex Tricarboxylic Acid Cycle Negative Regulation Of Insulin Secretion Regulation Of Mitotic Spindle Organization Positive Regulation Of Steroid Metabolic Process Negative Regulation Of Peptide Secretion Regulation Of Cholesterol Metabolic Process Lymphocyte Migration Negative Regulation Of Hormone Secretion G Protein Activity G Protein-coupled Receptor Binding Negative Regulation Of Protein Secretion Positive Regulation Of Protein Localization To Cell Periphery Chemokine-mediated Signaling Pathway Regulation Of Steroid Biosynthetic Process Nucleotide Binding Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Acyl-CoA Metabolic Process Dicarboxylic Acid Metabolic Process Neuropeptide Signaling Pathway
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