SUCLG2

Description		succinate-CoA ligase GDP-forming subunit beta
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GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Matrix Plasma Membrane Protein-containing Complex Succinate-CoA Ligase Complex Succinate-CoA Ligase Complex (GDP-forming)
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Catalytic Activity Succinate-CoA Ligase (ADP-forming) Activity Succinate-CoA Ligase (GDP-forming) Activity Protein Binding ATP Binding GTP Binding Ligase Activity GDP Binding Protein-containing Complex Binding Metal Ion Binding
	Biological Process	Tricarboxylic Acid Cycle Succinyl-CoA Metabolic Process Succinate Metabolic Process Succinyl-CoA Catabolic Process
Pathways		Citric acid cycle (TCA cycle) Mitochondrial protein degradation
Drugs		Phenethyl Isothiocyanate
Diseases
GWAS		Body mass index ( 28552196) Cerebrospinal AB1-42 levels in Alzheimer's disease dementia ( 25027320) Corneal astigmatism ( 22144915) Diabetic kidney disease ( 26305897) FEV1 ( 30804560) Height ( 20881960) Hip circumference ( 28552196) IgE levels ( 23146381) Lung function (FVC) ( 28166213 30804560) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Spontaneous preterm birth with premature rupture of membranes ( 31194736) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355) Urinary metabolite levels in chronic kidney disease ( 31959995)
Interacting Genes		3 interacting genes: GPR143 SGCG SUCLG1
Entrez ID		8801
HPRD ID		06799
Ensembl ID		ENSG00000172340
Uniprot IDs		Q96I99
PDB IDs		6WCV 7MSR 7MSS 7MST 8Z02 8Z03
Enriched GO Terms of Interacting Partners?		Regulation Of Melanosome Organization Regulation Of Melanosome Transport L-tyrosine Binding Eye Pigment Biosynthetic Process L-DOPA Binding L-DOPA Receptor Activity Succinate-CoA Ligase Complex (ADP-forming) Succinate-CoA Ligase Complex (GDP-forming) Succinate-CoA Ligase (GDP-forming) Activity Succinate-CoA Ligase (ADP-forming) Activity Pigment Metabolic Process Involved In Pigmentation Dystroglycan Complex Succinyl-CoA Catabolic Process Dopamine Binding Sarcoglycan Complex Succinyl-CoA Metabolic Process Establishment Of Melanosome Localization Pigment Granule Transport Melanosome Membrane Melanosome Localization Melanosome Transport Heart Contraction Pigment Granule Localization Heart Process Tricarboxylic Acid Cycle Melanosome Organization Pigment Granule Organization Pigment Metabolic Process Cardiac Muscle Tissue Development
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