SUCLG2 and SUCLG1

Number of citations: 0 (PubMedID 10873456)
Data Source: HPRD (in vitro)

		SUCLG2	SUCLG1
Name		succinate-CoA ligase GDP-forming subunit beta	succinate-CoA ligase GDP/ADP-forming subunit alpha
Structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Matrix Plasma Membrane Protein-containing Complex Succinate-CoA Ligase Complex Succinate-CoA Ligase Complex (GDP-forming)	Mitochondrion Mitochondrial Matrix Succinate-CoA Ligase Complex (ADP-forming) Succinate-CoA Ligase Complex (GDP-forming)
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Catalytic Activity Succinate-CoA Ligase (ADP-forming) Activity Succinate-CoA Ligase (GDP-forming) Activity Protein Binding ATP Binding GTP Binding Ligase Activity GDP Binding Protein-containing Complex Binding Metal Ion Binding	Nucleotide Binding RNA Binding Catalytic Activity Succinate-CoA Ligase (ADP-forming) Activity Succinate-CoA Ligase (GDP-forming) Activity Protein Binding Ligase Activity
	Biological Process	Tricarboxylic Acid Cycle Succinyl-CoA Metabolic Process Succinate Metabolic Process Succinyl-CoA Catabolic Process	Tricarboxylic Acid Cycle Succinyl-CoA Catabolic Process
Pathways		Citric acid cycle (TCA cycle) Mitochondrial protein degradation	Citric acid cycle (TCA cycle)
Drugs		Phenethyl Isothiocyanate	None
Diseases		None	Mitochondrial DNA depletion syndrome (MDS)
GWAS		Body mass index ( 28552196 ) Cerebrospinal AB1-42 levels in Alzheimer's disease dementia ( 25027320 ) Corneal astigmatism ( 22144915 ) Diabetic kidney disease ( 26305897 ) FEV1 ( 30804560 ) Height ( 20881960 ) Hip circumference ( 28552196 ) IgE levels ( 23146381 ) Lung function (FVC) ( 28166213 30804560 ) Mean corpuscular hemoglobin ( 32888494 ) Mean corpuscular volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Metabolite levels ( 23823483 ) Spontaneous preterm birth with premature rupture of membranes ( 31194736 ) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355 ) Urinary metabolite levels in chronic kidney disease ( 31959995 )	Coronary artery calcification ( 23870195 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Gut microbiota (functional units) ( 27694959 )
Interacting Genes		3 interacting genes: GPR143 SGCG SUCLG1	5 interacting genes: CCAR2 CHMP1B SUCLG2 UBC WDR36
Entrez ID		8801	8802
HPRD ID		06799	18128
Ensembl ID		ENSG00000172340	ENSG00000163541
Uniprot IDs		Q96I99	P53597
PDB IDs		6WCV 7MSR 7MSS 7MST 8Z02 8Z03	6G4Q 6WCV 7MSR 7MSS 7MST 8Z02 8Z03
GO Terms Enriched among Interactors		Regulation Of Melanosome Organization Regulation Of Melanosome Transport L-tyrosine Binding Eye Pigment Biosynthetic Process L-DOPA Binding L-DOPA Receptor Activity Succinate-CoA Ligase Complex (ADP-forming) Succinate-CoA Ligase Complex (GDP-forming) Succinate-CoA Ligase (GDP-forming) Activity Succinate-CoA Ligase (ADP-forming) Activity Pigment Metabolic Process Involved In Pigmentation Dystroglycan Complex Succinyl-CoA Catabolic Process Dopamine Binding Sarcoglycan Complex Succinyl-CoA Metabolic Process Establishment Of Melanosome Localization Pigment Granule Transport Melanosome Membrane Melanosome Localization Melanosome Transport Heart Contraction Pigment Granule Localization Heart Process Tricarboxylic Acid Cycle Melanosome Organization Pigment Granule Organization Pigment Metabolic Process Cardiac Muscle Tissue Development	Succinate-CoA Ligase (ADP-forming) Activity Succinate-CoA Ligase Complex Succinate-CoA Ligase Complex (GDP-forming) Succinate-CoA Ligase (GDP-forming) Activity MIT Domain Binding DBIRD Complex