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TNFRSF10B and TRADD
Number of citations of the paper that reports this interaction (PubMedID
9430227
)
0
Data Source:
HPRD
(in vivo)
TNFRSF10B
TRADD
Description
TNF receptor superfamily member 10b
TNFRSF1A associated via death domain
Image
GO Annotations
Cellular Component
Plasma Membrane
Cell Surface
Membrane
Tumor Necrosis Factor Receptor Superfamily Complex
Nucleus
Cytoplasm
Cytosol
Cytoskeleton
Plasma Membrane
Cytoplasmic Side Of Plasma Membrane
Death-inducing Signaling Complex
Receptor Complex
Molecular Function
Death Receptor Activity
Protein Binding
TRAIL Receptor Activity
Signaling Receptor Activity
TRAIL Binding
Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity
Protein Binding
Kinase Binding
Protein-macromolecule Adaptor Activity
Signaling Adaptor Activity
Identical Protein Binding
Molecular Adaptor Activity
Death Domain Binding
Biological Process
Defense Response To Tumor Cell
Apoptotic Process
Signal Transduction
Cell Surface Receptor Signaling Pathway
Activation Of NF-kappaB-inducing Kinase Activity
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Response To Endoplasmic Reticulum Stress
TRAIL-activated Apoptotic Signaling Pathway
Regulation Of Apoptotic Process
Positive Regulation Of Apoptotic Process
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
Cellular Response To Mechanical Stimulus
Apoptotic Process
Signal Transduction
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Canonical NF-kappaB Signal Transduction
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Positive Regulation Of Cell Migration
Tumor Necrosis Factor-mediated Signaling Pathway
TRAIL-activated Apoptotic Signaling Pathway
Non-canonical NF-kappaB Signal Transduction
Positive Regulation Of Apoptotic Process
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Inflammatory Response
Positive Regulation Of Hair Follicle Development
Cellular Response To Tumor Necrosis Factor
Apoptotic Signaling Pathway
Extrinsic Apoptotic Signaling Pathway
Pathways
Caspase activation via Death Receptors in the presence of ligand
Cell surface interactions at the vascular wall
Regulation by c-FLIP
RIPK1-mediated regulated necrosis
CASP8 activity is inhibited
TP53 Regulates Transcription of Death Receptors and Ligands
Dimerization of procaspase-8
TRAIL signaling
Caspase activation via Death Receptors in the presence of ligand
Regulation by c-FLIP
RIPK1-mediated regulated necrosis
CASP8 activity is inhibited
TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
TNFR1-induced NF-kappa-B signaling pathway
Regulation of necroptotic cell death
Dimerization of procaspase-8
TNF signaling
Defective RIPK1-mediated regulated necrosis
Drugs
HGS-TR2J
Lexatumumab
Diseases
GWAS
Blood protein levels (
30072576
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Monocyte count (
32888494
)
Monocyte percentage of white cells (
32888494
)
Parkinson's disease motor subtype (tremor to postural instability/gait difficulty score ratio) (
33987465
)
Renal cell carcinoma (
28598434
)
Interacting Genes
15 interacting genes:
ASPH
CASP8
CDC42
CFLAR
FADD
MADD
MUC1
RIPK1
TIMM50
TMEM31
TNFRSF10A
TNFRSF10D
TNFSF10
TRADD
ZDHHC15
24 interacting genes:
APBB2
BCL10
BIRC2
CNTRL
DAPK1
FADD
FAS
HIPK2
KRT14
KRT18
NGFR
PPP2R1A
RIPK1
STAT1
TMC8
TNFRSF10A
TNFRSF10B
TNFRSF1A
TNFRSF21
TNFRSF25
TRAF1
TRAF2
TRAF3
TRPC4AP
Entrez ID
8795
8717
HPRD ID
04680
04610
Ensembl ID
ENSG00000120889
ENSG00000102871
Uniprot IDs
O14763
Q15628
PDB IDs
1D0G
1D4V
1DU3
1ZA3
2H9G
3X3F
4I9X
4N90
4OD2
6NHW
6NHY
6T3J
8DPX
1F2H
1F3V
5XME
6AC0
7CSQ
Enriched GO Terms of Interacting Partners
?
Death-inducing Signaling Complex
TRAIL-activated Apoptotic Signaling Pathway
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Death Receptor Binding
Ripoptosome
Extrinsic Apoptotic Signaling Pathway
Apoptotic Process
Cell Death
Programmed Cell Death
TRAIL Binding
Apoptotic Signaling Pathway
CD95 Death-inducing Signaling Complex
Regulation Of Necroptotic Process
Regulation Of Programmed Necrotic Cell Death
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Regulation Of Apoptotic Process
Regulation Of Programmed Cell Death
Positive Regulation Of Apoptotic Process
Regulation Of Canonical NF-kappaB Signal Transduction
Regulation Of Extrinsic Apoptotic Signaling Pathway
Positive Regulation Of Macrophage Differentiation
Positive Regulation Of Programmed Cell Death
Negative Regulation Of Necroptotic Process
Positive Regulation Of Execution Phase Of Apoptosis
Negative Regulation Of Programmed Necrotic Cell Death
Regulation Of Apoptotic Signaling Pathway
Regulation Of Macrophage Differentiation
Death Domain Binding
Tumor Necrosis Factor Receptor Binding
Positive Regulation Of Intracellular Signal Transduction
Death Effector Domain Binding
Macrophage Differentiation
Tumor Necrosis Factor Receptor Superfamily Binding
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Positive Regulation Of Myeloid Leukocyte Differentiation
Necroptotic Signaling Pathway
Response To Mechanical Stimulus
Cell Surface Receptor Signaling Pathway
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Neuron Apoptotic Process
Cellular Response To Mechanical Stimulus
Positive Regulation Of Signal Transduction
Signaling Adaptor Activity
Regulation Of Cell Communication
Signal Transduction
Identical Protein Binding
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Negative Regulation Of Programmed Cell Death
Positive Regulation Of Myeloid Cell Differentiation
Tumor Necrosis Factor-mediated Signaling Pathway
Regulation Of Apoptotic Process
Regulation Of Programmed Cell Death
Apoptotic Process
Cell Death
Programmed Cell Death
Apoptotic Signaling Pathway
Extrinsic Apoptotic Signaling Pathway
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Regulation Of Canonical NF-kappaB Signal Transduction
Cytokine-mediated Signaling Pathway
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Signal Transduction
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Tumor Necrosis Factor Receptor Binding
Cellular Response To Mechanical Stimulus
Positive Regulation Of Apoptotic Signaling Pathway
Signaling Adaptor Activity
Regulation Of Apoptotic Signaling Pathway
Regulation Of Extrinsic Apoptotic Signaling Pathway
Death Receptor Activity
Response To Mechanical Stimulus
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Positive Regulation Of Signal Transduction
Regulation Of Intracellular Signal Transduction
Death-inducing Signaling Complex
Tumor Necrosis Factor Binding
Negative Regulation Of Apoptotic Process
Non-canonical NF-kappaB Signal Transduction
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Negative Regulation Of Programmed Cell Death
Regulation Of Signal Transduction
Lymphocyte Apoptotic Process
Necroptotic Signaling Pathway
TRAIL-activated Apoptotic Signaling Pathway
Tumor Necrosis Factor Receptor Activity
Thioesterase Binding
CD40 Receptor Complex
Neuron Apoptotic Process
Leukocyte Apoptotic Process
Regulation Of Cell Communication
Regulation Of Signaling
Signaling Receptor Activity
Negative Regulation Of Necroptotic Process
Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Programmed Necrotic Cell Death
Negative Regulation Of Programmed Necrotic Cell Death
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