TNFRSF10B and TIMM50

Number of citations of the paper that reports this interaction (PubMedID 15044455)
0

Data Source:
BioGRID (two hybrid)

		TNFRSF10B	TIMM50
Description		TNF receptor superfamily member 10b	translocase of inner mitochondrial membrane 50
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane	Nucleus Nucleoplasm Mitochondrion Mitochondrial Inner Membrane TIM23 Mitochondrial Import Inner Membrane Translocase Complex Endoplasmic Reticulum Golgi Apparatus Membrane Nuclear Speck
	Molecular Function	Death Receptor Activity Protein Binding TRAIL Receptor Activity Signaling Receptor Activity TRAIL Binding	RNA Binding Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Interleukin-2 Receptor Binding Protein Binding Ribonucleoprotein Complex Binding Cysteine-type Endopeptidase Activator Activity
	Biological Process	Defense Response To Tumor Cell Apoptotic Process Signal Transduction Cell Surface Receptor Signaling Pathway Activation Of NF-kappaB-inducing Kinase Activity Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Response To Endoplasmic Reticulum Stress TRAIL-activated Apoptotic Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Cellular Response To Mechanical Stimulus	Release Of Cytochrome C From Mitochondria Protein Dephosphorylation Intracellular Protein Transport Mitochondrial Membrane Organization Protein Transport Protein Import Into Mitochondrial Matrix
Pathways		Caspase activation via Death Receptors in the presence of ligand Cell surface interactions at the vascular wall Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited TP53 Regulates Transcription of Death Receptors and Ligands Dimerization of procaspase-8 TRAIL signaling	Mitochondrial protein import
Drugs		HGS-TR2J Lexatumumab
Diseases
GWAS		Blood protein levels ( 30072576) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Parkinson's disease motor subtype (tremor to postural instability/gait difficulty score ratio) ( 33987465) Renal cell carcinoma ( 28598434)
Interacting Genes		15 interacting genes: ASPH CASP8 CDC42 CFLAR FADD MADD MUC1 RIPK1 TIMM50 TMEM31 TNFRSF10A TNFRSF10D TNFSF10 TRADD ZDHHC15	6 interacting genes: DNM1 FILNC1 LY6E-DT PAFAH1B2 RAF1 TNFRSF10B
Entrez ID		8795	92609
HPRD ID		04680	12118
Ensembl ID		ENSG00000120889	ENSG00000105197
Uniprot IDs		O14763	Q3ZCQ8
PDB IDs		1D0G 1D4V 1DU3 1ZA3 2H9G 3X3F 4I9X 4N90 4OD2 6NHW 6NHY 6T3J 8DPX
Enriched GO Terms of Interacting Partners?		Death-inducing Signaling Complex TRAIL-activated Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Death Receptor Binding Ripoptosome Extrinsic Apoptotic Signaling Pathway Apoptotic Process Cell Death Programmed Cell Death TRAIL Binding Apoptotic Signaling Pathway CD95 Death-inducing Signaling Complex Regulation Of Necroptotic Process Regulation Of Programmed Necrotic Cell Death Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Process Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Macrophage Differentiation Positive Regulation Of Programmed Cell Death Negative Regulation Of Necroptotic Process Positive Regulation Of Execution Phase Of Apoptosis Negative Regulation Of Programmed Necrotic Cell Death Regulation Of Apoptotic Signaling Pathway Regulation Of Macrophage Differentiation Death Domain Binding Tumor Necrosis Factor Receptor Binding Positive Regulation Of Intracellular Signal Transduction Death Effector Domain Binding Macrophage Differentiation Tumor Necrosis Factor Receptor Superfamily Binding Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Myeloid Leukocyte Differentiation Necroptotic Signaling Pathway Response To Mechanical Stimulus Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Neuron Apoptotic Process Cellular Response To Mechanical Stimulus Positive Regulation Of Signal Transduction Signaling Adaptor Activity Regulation Of Cell Communication Signal Transduction Identical Protein Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Programmed Cell Death Positive Regulation Of Myeloid Cell Differentiation	Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Vesicle Scission Clathrin Coat Assembly Involved In Endocytosis Platelet-activating Factor Acetyltransferase Activity 1-alkyl-2-acetylglycerophosphocholine Esterase Complex Extrinsic Apoptotic Signaling Pathway Death-inducing Signaling Complex Assembly TRAIL Receptor Activity Death Receptor Activity Chromaffin Granule Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Adenylate Cyclase Activator Activity TRAIL Binding Response To Mechanical Stimulus 1-alkyl-2-acetylglycerophosphocholine Esterase Activity Positive Regulation Of Phosphorylation ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway Positive Regulation Of Protein Phosphorylation TRAIL-activated Apoptotic Signaling Pathway Defense Response To Tumor Cell Activation Of NF-kappaB-inducing Kinase Activity
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