TNFRSF10B and TIMM50

Number of citations of the paper that reports this interaction (PMID 15044455)
15

Data Source:
BioGRID (two hybrid)

		TNFRSF10B	TIMM50
Gene Name		tumor necrosis factor receptor superfamily, member 10b	translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Inner Membrane Presequence Translocase Complex Integral Component Of Membrane Nuclear Speck
	Molecular Function	Receptor Activity Protein Binding TRAIL Binding	RNA Binding Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Interleukin-2 Receptor Binding Protein Binding Ribonucleoprotein Complex Binding
	Biological Process	Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell Surface Receptor Signaling Pathway Activation Of NF-kappaB-inducing Kinase Activity Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Response To Endoplasmic Reticulum Stress Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Cellular Response To Mechanical Stimulus Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Release Of Cytochrome C From Mitochondria Protein Dephosphorylation Protein Targeting To Mitochondrion Mitochondrial Membrane Organization Peptidyl-tyrosine Dephosphorylation Cellular Protein Metabolic Process
Pathways		Regulation by c-FLIP Death Receptor Signalling TRAIL signaling Dimerization of procaspase-8 Caspase-8 activation by cleavage Programmed Cell Death Extrinsic Pathway	Mitochondrial protein import
Drugs
Diseases
GWAS
Protein-Protein Interactions		10 interactors: CASP8 CFLAR FADD MADD RIPK1 TIMM50 TNFRSF10A TNFRSF10D TNFSF10 TRADD	4 interactors: DNM1 PAFAH1B2 RAF1 TNFRSF10B
Entrez ID		8795	92609
HPRD ID		04680	12118
Ensembl ID		ENSG00000120889	ENSG00000105197
Uniprot IDs		O14763 Q7Z2I8	Q3ZCQ8
PDB IDs		1D0G 1D4V 1DU3 1ZA3 2H9G 4I9X
Enriched GO Terms of Interacting Partners?		Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Extrinsic Apoptotic Signaling Pathway Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Zymogen Activation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Apoptotic Process Positive Regulation Of Endopeptidase Activity Programmed Cell Death Cell Death Positive Regulation Of Peptidase Activity Death Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Protein Processing Positive Regulation Of Proteolysis Apoptotic Signaling Pathway Regulation Of Necroptotic Process Regulation Of Endopeptidase Activity Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling TRAIL-activated Apoptotic Signaling Pathway Regulation Of Peptidase Activity Positive Regulation Of Intracellular Signal Transduction Regulation Of Necrotic Cell Death Regulation Of Apoptotic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Cell Death Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Hydrolase Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Positive Regulation Of Cellular Protein Metabolic Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Proteolysis Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Positive Regulation Of Macrophage Differentiation Positive Regulation Of Catalytic Activity Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of Cellular Protein Metabolic Process Protein Heterooligomerization Regulation Of Protein Metabolic Process Regulation Of Catalytic Activity Negative Regulation Of Programmed Cell Death Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Cell Death Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors	Extrinsic Apoptotic Signaling Pathway Death-inducing Signaling Complex Assembly Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Activation Of Protein Kinase Activity Apoptotic Signaling Pathway Regulation Of Endopeptidase Activity Axon Guidance Response To External Stimulus Regulation Of Peptidase Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Positive Regulation Of Macroautophagy Axonogenesis Positive Regulation Of Transferase Activity Axon Development Nervous System Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Regulation Of Proteolysis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cellular Metabolic Process Activation Of Adenylate Cyclase Activity Activation Of NF-kappaB-inducing Kinase Activity Endosome Organization Cell Morphogenesis Involved In Differentiation Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Adenylate Cyclase Activity Positive Regulation Of Autophagy Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Clathrin-mediated Endocytosis Regulation Of Kinase Activity Positive Regulation Of Intracellular Signal Transduction Neuron Projection Development Intermediate Filament Cytoskeleton Organization NIK/NF-kappaB Signaling Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of NIK/NF-kappaB Signaling Cell Projection Morphogenesis Intermediate Filament-based Process Receptor Internalization Positive Regulation Of Phosphorylation Cell Part Morphogenesis Positive Regulation Of Lyase Activity Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Tagcloud ?		aa activator atm atmmutated bax cdkn1a cll combinations elicit harboring hot lymphocytic maintained mdm2 next notch1 notch1mutated notch1mutations notch2 nutlin showing spot subgroup subset surprisingly tp53 tp53mutated
Tagcloud (Difference) ?		aa activator atm atmmutated bax cdkn1a cll combinations elicit harboring hot lymphocytic maintained mdm2 next notch1 notch1mutated notch1mutations notch2 nutlin showing spot subgroup subset surprisingly tp53 tp53mutated
Tagcloud (Intersection) ?