TNFRSF10B

Name	TNF receptor superfamily member 10b
Structure
Novel Interactors	2 novel interactors: KCNQ3 PCM1
Interactors	15 interactors: ASPH CASP8 CDC42 CFLAR FADD MADD MUC1 RIPK1 TIMM50 TMEM31 TNFRSF10A TNFRSF10D TNFSF10 TRADD ZDHHC15
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane
	Molecular Function	Death Receptor Activity Protein Binding TRAIL Receptor Activity Signaling Receptor Activity TRAIL Binding
	Biological Process	Defense Response To Tumor Cell Apoptotic Process Signal Transduction Cell Surface Receptor Signaling Pathway Activation Of NF-kappaB-inducing Kinase Activity Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Response To Endoplasmic Reticulum Stress TRAIL-activated Apoptotic Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Cellular Response To Mechanical Stimulus
Pathways	Caspase activation via Death Receptors in the presence of ligand Cell surface interactions at the vascular wall Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited TP53 Regulates Transcription of Death Receptors and Ligands Dimerization of procaspase-8 TRAIL signaling
Drugs	HGS-TR2J Lexatumumab
GWAS	Blood protein levels ( 30072576 ) Mean corpuscular hemoglobin ( 32888494 ) Mean corpuscular volume ( 32888494 ) Monocyte count ( 32888494 ) Monocyte percentage of white cells ( 32888494 ) Parkinson's disease motor subtype (tremor to postural instability/gait difficulty score ratio) ( 33987465 ) Renal cell carcinoma ( 28598434 )
Entrez ID	8795
HPRD ID	04680
Ensembl ID	ENSG00000120889
Uniprot IDs	O14763
PDB IDs	1D0G 1D4V 1DU3 1ZA3 2H9G 3X3F 4I9X 4N90 4OD2 6NHW 6NHY 6T3J 8DPX
GO Terms Enriched among Interactors ?	Death-inducing Signaling Complex TRAIL-activated Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Death Receptor Binding Ripoptosome Extrinsic Apoptotic Signaling Pathway Apoptotic Process Cell Death Programmed Cell Death TRAIL Binding Apoptotic Signaling Pathway CD95 Death-inducing Signaling Complex Regulation Of Necroptotic Process Regulation Of Programmed Necrotic Cell Death Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Process Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Macrophage Differentiation Positive Regulation Of Programmed Cell Death Negative Regulation Of Necroptotic Process Positive Regulation Of Execution Phase Of Apoptosis Negative Regulation Of Programmed Necrotic Cell Death Regulation Of Apoptotic Signaling Pathway Regulation Of Macrophage Differentiation Death Domain Binding Tumor Necrosis Factor Receptor Binding Positive Regulation Of Intracellular Signal Transduction Death Effector Domain Binding Macrophage Differentiation Tumor Necrosis Factor Receptor Superfamily Binding Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Myeloid Leukocyte Differentiation Necroptotic Signaling Pathway Response To Mechanical Stimulus Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Neuron Apoptotic Process Cellular Response To Mechanical Stimulus Positive Regulation Of Signal Transduction Signaling Adaptor Activity Regulation Of Cell Communication Signal Transduction Identical Protein Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Programmed Cell Death Positive Regulation Of Myeloid Cell Differentiation