TNFRSF10B and MADD

Number of citations of the paper that reports this interaction (PMID 15208670)
11

Data Source:
HPRD (in vitro, in vivo)

		TNFRSF10B	MADD
Gene Name		tumor necrosis factor receptor superfamily, member 10b	MAP-kinase activating death domain
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane	Cytoplasm Plasma Membrane Integral Component Of Membrane
	Molecular Function	Receptor Activity Protein Binding TRAIL Binding	Death Receptor Binding Protein Binding Rab Guanyl-nucleotide Exchange Factor Activity Protein Kinase Activator Activity
	Biological Process	Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell Surface Receptor Signaling Pathway Activation Of NF-kappaB-inducing Kinase Activity Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Response To Endoplasmic Reticulum Stress Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Cellular Response To Mechanical Stimulus Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Activation Of MAPK Activity Cell Surface Receptor Signaling Pathway Regulation Of Rab Protein Signal Transduction Positive Regulation Of Rab GTPase Activity Regulation Of Apoptotic Process Regulation Of Cell Cycle Execution Phase Of Apoptosis Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Regulation by c-FLIP Death Receptor Signalling TRAIL signaling Dimerization of procaspase-8 Caspase-8 activation by cleavage Programmed Cell Death Extrinsic Pathway
Drugs
Diseases
GWAS			Fasting glucose-related traits ( 20081858) Fasting glucose-related traits (interaction with BMI) ( 22581228) HDL cholesterol ( 19060911) Proinsulin levels ( 21873549)
Protein-Protein Interactions		10 interactors: CASP8 CFLAR FADD MADD RIPK1 TIMM50 TNFRSF10A TNFRSF10D TNFSF10 TRADD	9 interactors: NPDC1 PIDD1 POT1 PTPRN TNFRSF10A TNFRSF10B TNFRSF1A VPS13D YWHAZ
Entrez ID		8795	8567
HPRD ID		04680	04664
Ensembl ID		ENSG00000120889	ENSG00000110514
Uniprot IDs		O14763 Q7Z2I8	Q8WXG6
PDB IDs		1D0G 1D4V 1DU3 1ZA3 2H9G 4I9X
Enriched GO Terms of Interacting Partners?		Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Extrinsic Apoptotic Signaling Pathway Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Zymogen Activation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Apoptotic Process Positive Regulation Of Endopeptidase Activity Programmed Cell Death Cell Death Positive Regulation Of Peptidase Activity Death Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Protein Processing Positive Regulation Of Proteolysis Apoptotic Signaling Pathway Regulation Of Necroptotic Process Regulation Of Endopeptidase Activity Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling TRAIL-activated Apoptotic Signaling Pathway Regulation Of Peptidase Activity Positive Regulation Of Intracellular Signal Transduction Regulation Of Necrotic Cell Death Regulation Of Apoptotic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Cell Death Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Hydrolase Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Positive Regulation Of Cellular Protein Metabolic Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Proteolysis Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Positive Regulation Of Macrophage Differentiation Positive Regulation Of Catalytic Activity Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of Cellular Protein Metabolic Process Protein Heterooligomerization Regulation Of Protein Metabolic Process Regulation Of Catalytic Activity Negative Regulation Of Programmed Cell Death Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Cell Death Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors	Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Cellular Response To Mechanical Stimulus Apoptotic Signaling Pathway Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Extrinsic Apoptotic Signaling Pathway Zymogen Activation Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Programmed Cell Death Positive Regulation Of Cysteine-type Endopeptidase Activity Cell Death Death Positive Regulation Of Endopeptidase Activity Positive Regulation Of Peptidase Activity Positive Regulation Of Signal Transduction Intrinsic Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Response To Mechanical Stimulus Regulation Of Apoptotic Process Activation Of NF-kappaB-inducing Kinase Activity Protein Processing Regulation Of Cell Death Positive Regulation Of NIK/NF-kappaB Signaling NIK/NF-kappaB Signaling Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Proteolysis Intracellular Signal Transduction Positive Regulation Of Hydrolase Activity Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Positive Regulation Of Cellular Protein Metabolic Process Hormone Secretion Positive Regulation Of DNA Strand Elongation Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Hormone Transport Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Dense Core Granule Maturation Positive Regulation Of Transferase Activity Regulation Of Signal Transduction Positive Regulation Of Catalytic Activity Telomere Formation Via Telomerase TRAIL-activated Apoptotic Signaling Pathway Regulation Of Proteolysis
Tagcloud ?		aa activator atm atmmutated bax cdkn1a cll combinations elicit harboring hot lymphocytic maintained mdm2 next notch1 notch1mutated notch1mutations notch2 nutlin showing spot subgroup subset surprisingly tp53 tp53mutated	abca1 abcg5 abcg8 atorvastatin causal challenging chow excised fads1 gwas hfd hypertensive list loci lpl nominally nr1h3 orthologs overlapped pcsk9 pltp qpcr qtl responded spontaneously stac3 staged suggestive timd4
Tagcloud (Difference) ?		aa activator atm atmmutated bax cdkn1a cll combinations elicit harboring hot lymphocytic maintained mdm2 next notch1 notch1mutated notch1mutations notch2 nutlin showing spot subgroup subset surprisingly tp53 tp53mutated	abca1 abcg5 abcg8 atorvastatin causal challenging chow excised fads1 gwas hfd hypertensive list loci lpl nominally nr1h3 orthologs overlapped pcsk9 pltp qpcr qtl responded spontaneously stac3 staged suggestive timd4
Tagcloud (Intersection) ?