SIGLEC5 and NAPB

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SIGLEC5	NAPB
Description		sialic acid binding Ig like lectin 5	NSF attachment protein beta
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Secretory Granule Membrane Tertiary Granule Membrane Ficolin-1-rich Granule Membrane	Membrane Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Extracellular Exosome Glutamatergic Synapse
	Molecular Function	Protein Binding Carbohydrate Binding Sialic Acid Binding	Soluble NSF Attachment Protein Activity Protein Binding Syntaxin Binding
	Biological Process	Cell Adhesion	Intracellular Protein Transport Regulation Of Synaptic Vesicle Priming Protein Transport Vesicle-mediated Transport Synaptic Transmission, Glutamatergic SNARE Complex Disassembly
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Neutrophil degranulation	COPII-mediated vesicle transport COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic Intra-Golgi traffic Retrograde transport at the Trans-Golgi-Network
Drugs
Diseases
GWAS		Addison's disease ( 33574239) Aggressive periodontitis ( 28449029) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Leprosy ( 25642632) Lymphocyte count ( 27863252 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Neutrophil percentage of white cells ( 32888494) Periodontitis ( 30218097) Platelet distribution width ( 32888494) Systemic lupus erythematosus ( 33272962)	Factor VII activity ( 30642921)
Interacting Genes		5 interacting genes: LGALS3BP NAPB SLC7A8 TRIP13 VAC14	32 interacting genes: ALOX5AP ARL6IP1 BET1 CISD2 CLEC10A CREB3L1 DGAT2L6 DSCAM FAM209A GJB5 HSD17B13 KCNN3 LEUTX PLEKHO1 SDCBP SIGLEC5 SNAP23 SNAP29 STX16 STX19 STX1A STX1B STX2 STX3 STX4 STX5 STX6 SYT1 SYT2 TAF1B TFEC TMEM139
Entrez ID		8778	63908
HPRD ID		05011	17627
Ensembl ID		ENSG00000268500	ENSG00000125814
Uniprot IDs		O15389	A0A087WZQ7 Q9H115
PDB IDs		2ZG1 2ZG2 2ZG3
Enriched GO Terms of Interacting Partners?		Female Meiosis I Meiotic Recombination Checkpoint Signaling Meiotic Cell Cycle Checkpoint Signaling L-alanine Transport Tryptophan Transport Proline Transmembrane Transport L-alanine Transmembrane Transport L-leucine Transmembrane Transporter Activity Toxin Transmembrane Transporter Activity L-leucine Import Across Plasma Membrane Glycine Transmembrane Transporter Activity L-alanine Transmembrane Transporter Activity L-alanine Import Across Plasma Membrane Thyroid Hormone Transmembrane Transporter Activity Valine Transport PAS Complex Presynaptic Endosome Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Soluble NSF Attachment Protein Activity SNARE Complex Disassembly Negative Regulation Of Meiotic Nuclear Division Branched-chain Amino Acid Transport Organic Cation Transmembrane Transporter Activity Aromatic Amino Acid Transport L-leucine Transport Thyroid Hormone Transport Regulation Of Synaptic Vesicle Priming Glycine Transport Platelet Dense Granule Lumen L-amino Acid Transmembrane Transporter Activity Alanine Transport Negative Regulation Of Meiotic Cell Cycle Female Meiotic Nuclear Division Neutral L-amino Acid Transmembrane Transporter Activity Synaptonemal Complex Assembly Scavenger Receptor Activity Oocyte Maturation Mitotic Spindle Assembly Checkpoint Signaling Negative Regulation Of Mitotic Metaphase/anaphase Transition Synaptonemal Complex Organization Male Meiosis I Regulation Of Meiotic Nuclear Division Reciprocal Meiotic Recombination Microvillus Membrane Amino Acid Import Across Plasma Membrane Amino Acid Transmembrane Transporter Activity Peptide Antigen Binding Regulation Of Postsynaptic Neurotransmitter Receptor Internalization	SNAP Receptor Activity SNARE Complex Vesicle Fusion Organelle Membrane Fusion Organelle Fusion SNARE Binding Membrane Fusion Organelle Localization By Membrane Tethering Membrane Docking Vesicle Docking Vesicle Organization Membrane Organization Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Vesicle Fusion To Plasma Membrane Endomembrane System Synaptic Vesicle Membrane Organization Exocytosis Organelle Localization Vesicle-mediated Transport Secretion By Cell Secretion Establishment Of Protein Localization Membrane Syntaxin Binding Presynaptic Active Zone Membrane Protein Transport Intracellular Protein Transport Neurotransmitter Transport Specific Granule Synaptic Vesicle Membrane Positive Regulation Of Neurotransmitter Secretion Positive Regulation Of Synaptic Transmission Cellular Localization Establishment Of Localization In Cell Organelle Organization Positive Regulation Of Exocytosis Regulation Of Neurotransmitter Secretion Regulation Of Exocytosis Vesicle-mediated Transport In Synapse Synaptic Vesicle Exocytosis Neuron Projection Calcium-ion Regulated Exocytosis Intracellular Transport Intracellular Protein Localization Arachidonate Binding Cornified Envelope Assembly Spontaneous Neurotransmitter Secretion Regulation Of Calcium Ion-dependent Exocytosis Regulation Of Regulated Secretory Pathway Chromaffin Granule Membrane
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