NAPB and ALOX5AP

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NAPB	ALOX5AP
Description		NSF attachment protein beta	arachidonate 5-lipoxygenase activating protein
Image		No pdb structure
GO Annotations	Cellular Component	Membrane Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Extracellular Exosome Glutamatergic Synapse	Nucleus Nuclear Envelope Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Nuclear Membrane
	Molecular Function	Soluble NSF Attachment Protein Activity Protein Binding Syntaxin Binding	Glutathione Transferase Activity Leukotriene-C4 Synthase Activity Glutathione Peroxidase Activity Protein Binding Enzyme Activator Activity Arachidonate Binding
	Biological Process	Intracellular Protein Transport Regulation Of Synaptic Vesicle Priming Protein Transport Vesicle-mediated Transport Synaptic Transmission, Glutamatergic SNARE Complex Disassembly	Leukotriene Production Involved In Inflammatory Response Leukotriene Metabolic Process Leukotriene Biosynthetic Process Carboxylic Acid Biosynthetic Process Protein Homotrimerization Cellular Response To Calcium Ion Cellular Oxidant Detoxification
Pathways		COPII-mediated vesicle transport COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic Intra-Golgi traffic Retrograde transport at the Trans-Golgi-Network	Synthesis of 5-eicosatetraenoic acids Synthesis of Leukotrienes (LT) and Eoxins (EX) Biosynthesis of Lipoxins (LX)
Drugs			DG031 AM103 Fiboflapon Veliflapon MK-886
Diseases
GWAS		Factor VII activity ( 30642921)	Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+epirubicin+/-5FU) ( 24025145) General risk tolerance (MTAG) ( 30643258) Non-word repetition ( 23738518)
Interacting Genes		32 interacting genes: ALOX5AP ARL6IP1 BET1 CISD2 CLEC10A CREB3L1 DGAT2L6 DSCAM FAM209A GJB5 HSD17B13 KCNN3 LEUTX PLEKHO1 SDCBP SIGLEC5 SNAP23 SNAP29 STX16 STX19 STX1A STX1B STX2 STX3 STX4 STX5 STX6 SYT1 SYT2 TAF1B TFEC TMEM139	10 interacting genes: ALOX5 AQP6 CLIC1 FFAR2 GPR42 LTC4S NAPB OPRM1 SLC29A2 TMEM120B
Entrez ID		63908	241
HPRD ID		17627	04742
Ensembl ID		ENSG00000125814	ENSG00000132965
Uniprot IDs		A0A087WZQ7 Q9H115	A0A087WW23 P20292
PDB IDs			2Q7M 2Q7R 6VGC 6VGI
Enriched GO Terms of Interacting Partners?		SNAP Receptor Activity SNARE Complex Vesicle Fusion Organelle Membrane Fusion Organelle Fusion SNARE Binding Membrane Fusion Organelle Localization By Membrane Tethering Membrane Docking Vesicle Docking Vesicle Organization Membrane Organization Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Vesicle Fusion To Plasma Membrane Endomembrane System Synaptic Vesicle Membrane Organization Exocytosis Organelle Localization Vesicle-mediated Transport Secretion By Cell Secretion Establishment Of Protein Localization Membrane Syntaxin Binding Presynaptic Active Zone Membrane Protein Transport Intracellular Protein Transport Neurotransmitter Transport Specific Granule Synaptic Vesicle Membrane Positive Regulation Of Neurotransmitter Secretion Positive Regulation Of Synaptic Transmission Cellular Localization Establishment Of Localization In Cell Organelle Organization Positive Regulation Of Exocytosis Regulation Of Neurotransmitter Secretion Regulation Of Exocytosis Vesicle-mediated Transport In Synapse Synaptic Vesicle Exocytosis Neuron Projection Calcium-ion Regulated Exocytosis Intracellular Transport Intracellular Protein Localization Arachidonate Binding Cornified Envelope Assembly Spontaneous Neurotransmitter Secretion Regulation Of Calcium Ion-dependent Exocytosis Regulation Of Regulated Secretory Pathway Chromaffin Granule Membrane	Leukocyte Chemotaxis Involved In Inflammatory Response Leukocyte Migration Involved In Inflammatory Response Leukotriene Biosynthetic Process Leukocyte Chemotaxis Leukotriene Metabolic Process Cell Chemotaxis Regulation Of Protein Secretion Long-chain Fatty Acid Biosynthetic Process Leukocyte Migration Leukotriene A4 Biosynthetic Process Arachidonate 5-lipoxygenase Activity Nuclear Envelope Nuclear Membrane Negative Regulation Of Endothelial Cell Proliferation Membrane Icosanoid Biosynthetic Process Nitrate Transmembrane Transporter Activity Placental Growth Factor Receptor Activity Vascular Endothelial Growth Factor Receptor-1 Signaling Pathway Morphine Receptor Activity Negative Regulation Of Wnt Protein Secretion Beta-endorphin Receptor Activity Response To Metformin Leukotriene A4 Metabolic Process Locomotion Leukotriene Production Involved In Inflammatory Response Long-chain Fatty Acid Metabolic Process Icosanoid Metabolic Process Arachidonate 8(S)-lipoxygenase Activity Lipoxin Biosynthetic Process Positive Regulation Of Developmental Process Arachidonate 12(S)-lipoxygenase Activity Chemotaxis Positive Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell PH-gated Chloride Channel Activity Nitrate Transmembrane Transport Chloride Transmembrane Transport G Protein-coupled Receptor Activity Positive Regulation Of Acute Inflammatory Response To Non-antigenic Stimulus Negative Regulation Of Protein Secretion Uracil Transmembrane Transport Thymine Transport Pyrimidine Nucleobase Transmembrane Transport Nucleobase Transmembrane Transporter Activity Uracil Transmembrane Transporter Activity Hypoxanthine Transport Purine Nucleoside Transmembrane Transporter Activity Cellular Response To Morphine Soluble NSF Attachment Protein Activity SNARE Complex Disassembly
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