SIGLEC5 and SLC7A8

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SIGLEC5	SLC7A8
Description		sialic acid binding Ig like lectin 5	solute carrier family 7 member 8
Image
GO Annotations	Cellular Component	Plasma Membrane Membrane Secretory Granule Membrane Tertiary Granule Membrane Ficolin-1-rich Granule Membrane	Plasma Membrane Basal Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Microvillus Membrane
	Molecular Function	Protein Binding Carbohydrate Binding Sialic Acid Binding	Protein Binding Organic Cation Transmembrane Transporter Activity Amino Acid Transmembrane Transporter Activity Neutral L-amino Acid Transmembrane Transporter Activity L-amino Acid Transmembrane Transporter Activity L-alanine Transmembrane Transporter Activity Glycine Transmembrane Transporter Activity L-leucine Transmembrane Transporter Activity Antiporter Activity Thyroid Hormone Transmembrane Transporter Activity Toxin Transmembrane Transporter Activity Transmembrane Transporter Activity Peptide Antigen Binding Protein Heterodimerization Activity
	Biological Process	Cell Adhesion	Amino Acid Transmembrane Transport Amino Acid Transport Neutral Amino Acid Transport L-amino Acid Transport Glycine Transport L-leucine Transport Tryptophan Transport Valine Transport Proline Transmembrane Transport Transmembrane Transport Thyroid Hormone Transport Amino Acid Import Across Plasma Membrane Transport Across Blood-brain Barrier L-leucine Import Across Plasma Membrane L-alanine Import Across Plasma Membrane
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Neutrophil degranulation	Basigin interactions Amino acid transport across the plasma membrane
Drugs			Phenylalanine Alanine
Diseases
GWAS		Addison's disease ( 33574239) Aggressive periodontitis ( 28449029) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Leprosy ( 25642632) Lymphocyte count ( 27863252 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Neutrophil percentage of white cells ( 32888494) Periodontitis ( 30218097) Platelet distribution width ( 32888494) Systemic lupus erythematosus ( 33272962)	Femur bone mineral density x serum urate levels interaction ( 34046847)
Interacting Genes		5 interacting genes: LGALS3BP NAPB SLC7A8 TRIP13 VAC14	26 interacting genes: ABHD16A AGPAT4 AQP6 COMT DERL1 FXYD6-FXYD2 MFF NDUFA3 NINJ2 REEP4 SIGLEC5 SLC25A46 SLC30A2 SLC33A2 SLC3A1 SLC3A2 SMPD2 SNORC SYCE1L SYNJ2BP TMEM14B TMEM208 TMEM60 TMEM65 YIPF1 YIPF6
Entrez ID		8778	23428
HPRD ID		05011	11971
Ensembl ID		ENSG00000268500	ENSG00000092068
Uniprot IDs		O15389	Q53EM9 Q9UHI5
PDB IDs		2ZG1 2ZG2 2ZG3	7B00 7CMH 7CMI 8A6L
Enriched GO Terms of Interacting Partners?		Female Meiosis I Meiotic Recombination Checkpoint Signaling Meiotic Cell Cycle Checkpoint Signaling L-alanine Transport Tryptophan Transport Proline Transmembrane Transport L-alanine Transmembrane Transport L-leucine Transmembrane Transporter Activity Toxin Transmembrane Transporter Activity L-leucine Import Across Plasma Membrane Glycine Transmembrane Transporter Activity L-alanine Transmembrane Transporter Activity L-alanine Import Across Plasma Membrane Thyroid Hormone Transmembrane Transporter Activity Valine Transport PAS Complex Presynaptic Endosome Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Soluble NSF Attachment Protein Activity SNARE Complex Disassembly Negative Regulation Of Meiotic Nuclear Division Branched-chain Amino Acid Transport Organic Cation Transmembrane Transporter Activity Aromatic Amino Acid Transport L-leucine Transport Thyroid Hormone Transport Regulation Of Synaptic Vesicle Priming Glycine Transport Platelet Dense Granule Lumen L-amino Acid Transmembrane Transporter Activity Alanine Transport Negative Regulation Of Meiotic Cell Cycle Female Meiotic Nuclear Division Neutral L-amino Acid Transmembrane Transporter Activity Synaptonemal Complex Assembly Scavenger Receptor Activity Oocyte Maturation Mitotic Spindle Assembly Checkpoint Signaling Negative Regulation Of Mitotic Metaphase/anaphase Transition Synaptonemal Complex Organization Male Meiosis I Regulation Of Meiotic Nuclear Division Reciprocal Meiotic Recombination Microvillus Membrane Amino Acid Import Across Plasma Membrane Amino Acid Transmembrane Transporter Activity Peptide Antigen Binding Regulation Of Postsynaptic Neurotransmitter Receptor Internalization	Membrane Golgi Trans Cisterna Golgi Medial Cisterna Sulfur Amino Acid Transport Mitochondrial Fission Mitochondrial Outer Membrane Basic Amino Acid Transport
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