KCNJ15 and CTSE

		KCNJ15	CTSE
Description		potassium inwardly rectifying channel subfamily J member 15	cathepsin E
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Monoatomic Ion Channel Complex	Endosome
	Molecular Function	Inward Rectifier Potassium Channel Activity Potassium Channel Activity Protein Binding	Aspartic-type Endopeptidase Activity Peptidase Activity Hydrolase Activity Identical Protein Binding
	Biological Process	Monoatomic Ion Transport Potassium Ion Transport Metal Ion Transport Monoatomic Ion Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Potassium Ion Import Across Plasma Membrane	Proteolysis Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
Pathways		Activation of G protein gated Potassium channels Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	MHC class II antigen presentation
Drugs		Ritodrine Yohimbine Butamben
Diseases
GWAS		A body shape index ( 34021172) Appendicular lean mass ( 33097823) Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Metabolite levels ( 23823483) Monocyte count ( 32888494) Non-response to antidepressants and depression ( 27622933) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		6 interacting genes: IL16 KCNJ16 KCNJ2 KCNJ5 PATJ SNTA1	5 interacting genes: A2M BAG6 EDN3 EMG1 INS
Entrez ID		3772	1510
HPRD ID		03659	00294
Ensembl ID		ENSG00000157551	ENSG00000196188
Uniprot IDs		Q99712	A0A7P0MPN9 B4DNU8 P14091
PDB IDs			1TZS
Enriched GO Terms of Interacting Partners?		Regulation Of Monoatomic Ion Transport Membrane Repolarization During Action Potential Membrane Repolarization During Cardiac Muscle Cell Action Potential Voltage-gated Potassium Channel Complex Inward Rectifier Potassium Channel Activity Membrane Repolarization Regulation Of Heart Rate Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Membrane Repolarization Voltage-gated Potassium Channel Activity Involved In Cardiac Muscle Cell Action Potential Repolarization Cardiac Muscle Cell Action Potential Involved In Contraction Monoatomic Ion Channel Complex Regulation Of Heart Rate By Cardiac Conduction Cardiac Muscle Cell Action Potential Potassium Ion Import Across Plasma Membrane Potassium Ion Transmembrane Transport Cardiac Conduction Potassium Ion Transport Regulation Of Heart Contraction Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Ventricular Cardiac Muscle Cell Membrane Repolarization Regulation Of Blood Circulation Inorganic Cation Import Across Plasma Membrane Ventricular Cardiac Muscle Cell Action Potential Action Potential Metal Ion Transport Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Regulation Of Metal Ion Transport Positive Regulation Of Potassium Ion Transmembrane Transport Inorganic Ion Transmembrane Transport Import Across Plasma Membrane Positive Regulation Of Potassium Ion Transport Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Regulation Of Membrane Potential Kinesin Binding Regulation Of Skeletal Muscle Contraction Via Regulation Of Action Potential Ammon Gyrus Development Dendrite Morphogenesis Monoatomic Ion Transport Regulation Of System Process Post-embryonic Retina Morphogenesis In Camera-type Eye Netrin Receptor Binding Regulation Of Potassium Ion Transmembrane Transport Vestibular Nucleus Development Regulation Of Monoatomic Cation Transmembrane Transport Relaxation Of Skeletal Muscle	Signaling Receptor Binding Negative Regulation Of Innate Immune Response Protease Binding Interleukin-8 Binding Negative Regulation Of Complement Activation, Lectin Pathway Potassium Ion Transmembrane Transport Blood Vessel Diameter Maintenance Vein Smooth Muscle Contraction Endothelin B Receptor Binding Regulation Of Tube Size Regulation Of Nuclear Division Regulation Of Mitotic Nuclear Division Hormone Activity Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Hormone Secretion Alpha-beta T Cell Activation Positive Regulation Of Nitric-oxide Synthase Activity Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Proteolysis Receptor Ligand Activity Negative Regulation Of Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Glycogen Catabolic Process Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Maintenance Of Unfolded Protein BAT3 Complex RRNA (pseudouridine) Methyltransferase Activity Nucleologenesis Regulation Of Immune System Process Potassium Ion Transport Negative Regulation Of Respiratory Burst Involved In Inflammatory Response Positive Regulation Of Nitric Oxide Mediated Signal Transduction Positive Regulation Of Dendritic Spine Maintenance Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Systemic Arterial Blood Pressure By Endothelin Intracellular Magnesium Ion Homeostasis Negative Regulation Of Respiratory Burst Nucleolus Organization Tumor Necrosis Factor Binding Interleukin-1 Binding Negative Regulation Of Feeding Behavior Regulation Of Nitric-oxide Synthase Activity Negative Regulation Of Immune Response Regulation Of Respiratory Burst Involved In Inflammatory Response Regulation Of Glycogen Catabolic Process Internal Peptidyl-lysine Acetylation Positive Regulation Of Respiratory Burst Nitric Oxide-cGMP-mediated Signaling NK T Cell Activation RRNA Base Methylation
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