KCNJ15 and CBR3

Data Source: HiPPIP (Novel)

		KCNJ15	CBR3
Name		potassium inwardly rectifying channel subfamily J member 15	carbonyl reductase 3
Structure		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Monoatomic Ion Channel Complex	Extracellular Space Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Inward Rectifier Potassium Channel Activity Potassium Channel Activity Protein Binding	3-beta-hydroxysteroid 3-dehydrogenase (NADP+) Activity Carbonyl Reductase (NADPH) Activity Protein Binding NADPH Dehydrogenase (quinone) Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Oxidoreductase Activity, Acting On NAD(P)H, Quinone Or Similar Compound As Acceptor NADPH Binding
	Biological Process	Monoatomic Ion Transport Potassium Ion Transport Metal Ion Transport Monoatomic Ion Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Potassium Ion Import Across Plasma Membrane	Xenobiotic Metabolic Process Phylloquinone Catabolic Process Cognition
Pathways		Activation of G protein gated Potassium channels Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	Phase I - Functionalization of compounds
Drugs		Ritodrine Yohimbine Butamben	None
GWAS		A body shape index ( 34021172 ) Appendicular lean mass ( 33097823 ) Basophil count ( 32888494 ) Basophil percentage of white cells ( 32888494 ) Height ( 31562340 ) Hip circumference adjusted for BMI ( 34021172 ) Metabolite levels ( 23823483 ) Monocyte count ( 32888494 ) Non-response to antidepressants and depression ( 27622933 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )	Blood protein levels ( 30072576 ) Lumbar spine bone mineral density ( 22504420 )
Novel Interactors		10 novel interactors: CBR3 CTSE DSCAM KCNE1 LRP8 MTCH1 SLC39A2 SON TOR1B TTC3	10 novel interactors: ANK1 ATP5PO CLU IL10RB ITSN1 KCNE1 KCNJ15 PCP4 RCAN1 SHOX2
Interacting Genes		6 interacting genes: IL16 KCNJ16 KCNJ2 KCNJ5 PATJ SNTA1	7 interacting genes: ARIH2 BICD2 RAB35 RANBP9 S100A10 SDCBP UBC
Entrez ID		3772	874
HPRD ID		03659	07222
Ensembl ID		ENSG00000157551	ENSG00000159231
Uniprot IDs		Q99712	O75828 V9HW40
PDB IDs		Not available	2HRB
GO Terms Enriched among Interactors		Regulation Of Monoatomic Ion Transport Membrane Repolarization During Action Potential Membrane Repolarization During Cardiac Muscle Cell Action Potential Voltage-gated Potassium Channel Complex Inward Rectifier Potassium Channel Activity Membrane Repolarization Regulation Of Heart Rate Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Membrane Repolarization Voltage-gated Potassium Channel Activity Involved In Cardiac Muscle Cell Action Potential Repolarization Cardiac Muscle Cell Action Potential Involved In Contraction Monoatomic Ion Channel Complex Regulation Of Heart Rate By Cardiac Conduction Cardiac Muscle Cell Action Potential Potassium Ion Import Across Plasma Membrane Potassium Ion Transmembrane Transport Cardiac Conduction Potassium Ion Transport Regulation Of Heart Contraction Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Ventricular Cardiac Muscle Cell Membrane Repolarization Regulation Of Blood Circulation Inorganic Cation Import Across Plasma Membrane Ventricular Cardiac Muscle Cell Action Potential Action Potential Metal Ion Transport Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Regulation Of Metal Ion Transport Positive Regulation Of Potassium Ion Transmembrane Transport Inorganic Ion Transmembrane Transport Import Across Plasma Membrane Positive Regulation Of Potassium Ion Transport Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Regulation Of Membrane Potential Kinesin Binding Regulation Of Skeletal Muscle Contraction Via Regulation Of Action Potential Ammon Gyrus Development Dendrite Morphogenesis Monoatomic Ion Transport Regulation Of System Process Post-embryonic Retina Morphogenesis In Camera-type Eye Netrin Receptor Binding Regulation Of Potassium Ion Transmembrane Transport Vestibular Nucleus Development Regulation Of Monoatomic Cation Transmembrane Transport Relaxation Of Skeletal Muscle	Cytoskeletal Anchor Activity Plasma Membrane Apical Dendrite