SELENBP1 and GPX1

Number of citations of the paper that reports this interaction (PMID 20530237)
9

Data Source:
BioGRID (affinity chromatography technology, fluorescent resonance energy transfer)

		SELENBP1	GPX1
Gene Name		selenium binding protein 1	glutathione peroxidase 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Nucleolus Cytosol Membrane Extracellular Vesicular Exosome	Nucleus Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Extracellular Vesicular Exosome Lewy Body
	Molecular Function	Protein Binding Selenium Binding	Glutathione Peroxidase Activity Selenium Binding SH3 Domain Binding Glutathione Binding Phospholipid-hydroperoxide Glutathione Peroxidase Activity
	Biological Process	Protein Transport	Response To Reactive Oxygen Species Temperature Homeostasis Endothelial Cell Development Negative Regulation Of Inflammatory Response To Antigenic Stimulus Purine Nucleobase Metabolic Process Purine Nucleotide Catabolic Process Triglyceride Metabolic Process Glutathione Metabolic Process Response To Lipid Hydroperoxide Aging Sensory Perception Of Sound Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Response To Xenobiotic Stimulus Response To Symbiotic Bacterium Response To Toxic Substance UV Protection Response To Glucose Response To Selenium Ion Response To Gamma Radiation Protein Oxidation Arachidonic Acid Metabolic Process Lipoxygenase Pathway Response To Estradiol Regulation Of Mammary Gland Epithelial Cell Proliferation Cellular Response To Oxidative Stress Response To Nicotine Regulation Of Gene Expression, Epigenetic Vasodilation Response To Hydrogen Peroxide Hydrogen Peroxide Catabolic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Skeletal Muscle Tissue Regeneration Regulation Of Neuron Apoptotic Process Blood Vessel Endothelial Cell Migration Small Molecule Metabolic Process Fat Cell Differentiation Cell Redox Homeostasis Skeletal Muscle Fiber Development Myoblast Proliferation Response To Folic Acid Interaction With Symbiont Positive Regulation Of Protein Kinase B Signaling Nucleobase-containing Small Molecule Metabolic Process Heart Contraction Angiogenesis Involved In Wound Healing Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Release Of Cytochrome C From Mitochondria Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Fibril Organization
Pathways			Arachidonic acid metabolism Purine catabolism Synthesis of 5-eicosatetraenoic acids Metabolism of lipids and lipoproteins Purine metabolism Synthesis of 12-eicosatetraenoic acid derivatives Synthesis of 15-eicosatetraenoic acid derivatives Detoxification of Reactive Oxygen Species Metabolism of nucleotides
Drugs			Glutathione
Diseases
GWAS		Blood trace element (Cu levels) ( 23720494)	Crohn's disease ( 21102463) Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		12 interactors: BARD1 EED GORASP2 GPX1 LRIF1 MED31 MLH1 POLDIP2 RPA1 TRA2A TRIP13 USP33	5 interactors: ABL1 ABL2 FAM9B MAPK6 SELENBP1
Entrez ID		8991	2876
HPRD ID		05007	11749
Ensembl ID		ENSG00000143416	ENSG00000233276
Uniprot IDs		A6PVW9 Q13228	P07203 Q7L4Q3
PDB IDs			2F8A
Enriched GO Terms of Interacting Partners?		Cell Cycle Cellular Response To Stress Nucleobase-containing Compound Metabolic Process Double-strand Break Repair Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Meiotic Nuclear Division Cell Cycle Process Cellular Nitrogen Compound Metabolic Process Meiotic Cell Cycle DNA Repair DNA Recombination Multicellular Organismal Homeostasis Nitrogen Compound Metabolic Process Reciprocal Meiotic Recombination Organelle Organization Synapsis Mismatch Repair Homologous Chromosome Segregation Male Meiosis Meiotic Spindle Midzone Assembly Positive Regulation Of Fibril Organization Meiotic Metaphase I Plate Congression Cellular Response To DNA Damage Stimulus Oogenesis Meiotic Chromosome Segregation Regulation Of Protein Catabolic Process Negative Regulation Of Mitotic Recombination Negative Regulation Of MRNA 3'-end Processing Response To Symbiotic Bacterium Chromosome Organization Meiosis I Aromatic Compound Catabolic Process Female Gamete Generation DNA Metabolic Process Regulation Of Fibril Organization Regulation Of Mitotic Recombination Male Meiosis Chromosome Segregation Response To Lipid Hydroperoxide DNA Recombinase Assembly RNA Metabolic Process Myoblast Proliferation Negative Regulation Of Protein Export From Nucleus Protein Oxidation Response To Selenium Ion Tissue Homeostasis Response To Stress Gene Expression Protein K6-linked Ubiquitination Intrinsic Apoptotic Signaling Pathway	Positive Regulation Of Interferon-gamma Secretion Bergmann Glial Cell Differentiation Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Interleukin-2 Secretion Positive Regulation Of Non-canonical Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Negative Regulation Of Endothelial Cell Apoptotic Process Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Interleukin-2 Production Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Oxidoreductase Activity Regulation Of Actin Cytoskeleton Reorganization Regulation Of Extracellular Matrix Organization Astrocyte Differentiation Platelet-derived Growth Factor Receptor Signaling Pathway Cerebellum Morphogenesis Positive Regulation Of Interferon-gamma Production Hindbrain Morphogenesis Alpha-beta T Cell Differentiation Alpha-beta T Cell Activation Regulation Of Oxidoreductase Activity Neuromuscular Process Controlling Balance Regulation Of Phospholipase Activity Regulation Of Interferon-gamma Production Positive Regulation Of Cytokine Secretion Regulation Of Autophagy Cerebellum Development Transitional One Stage B Cell Differentiation Metencephalon Development Positive Regulation Of ERK1 And ERK2 Cascade Neuromuscular Process Regulation Of Cytokine Secretion Negative Regulation Of Cell-cell Adhesion Positive Regulation Of Wnt Signaling Pathway T Cell Differentiation Positive Regulation Of Cytosolic Calcium Ion Concentration Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Hindbrain Development Negative Regulation Of Phospholipase C Activity Mitochondrial Depolarization Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cytosolic Calcium Ion Homeostasis Glial Cell Differentiation Regulation Of Endocytosis Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Protein Secretion Negative Regulation Of Cell Adhesion Protein Autophosphorylation Cellular Response To Dopamine
Tagcloud ?		aci arthritis ccl2 chemicals cia10 cia25 cia3d cia5a cigarette clec4m congenic congenics core correlating da erosive f344 mediators nonerosive nongenetic nongenetically rheumatoid scd1 slc7a10 spond1 synovial tnn upstream xenobiotic	adequately antifouling aquatic carp carpio chronically contaminants cyprinus fishes glutathione gr gsh gst gstp1 indicators juvenile lethal malondialdehyde organotin paints peroxidase pollutants recognised reductase ships tbt transferase tributyltin
Tagcloud (Difference) ?		aci arthritis ccl2 chemicals cia10 cia25 cia3d cia5a cigarette clec4m congenic congenics core correlating da erosive f344 mediators nonerosive nongenetic nongenetically rheumatoid scd1 slc7a10 spond1 synovial tnn upstream xenobiotic	adequately antifouling aquatic carp carpio chronically contaminants cyprinus fishes glutathione gr gsh gst gstp1 indicators juvenile lethal malondialdehyde organotin paints peroxidase pollutants recognised reductase ships tbt transferase tributyltin
Tagcloud (Intersection) ?