SELENBP1 and GPX1

Number of citations: 45 (PubMedID 20530237)
Data Source: BioGRID (affinity chromatography technology, fluorescent resonance energy transfer)

		SELENBP1	GPX1
Name		selenium binding protein 1	glutathione peroxidase 1
Structure		No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Extracellular Space Nucleus Nucleolus Cytoplasm Cytosol Membrane Extracellular Exosome	Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Lewy Body
	Molecular Function	Protein Binding Selenium Binding Oxidoreductase Activity Methanethiol Oxidase Activity	Peroxidase Activity Glutathione Peroxidase Activity Protein Binding Oxidoreductase Activity SH3 Domain Binding Phospholipid-hydroperoxide Glutathione Peroxidase Activity Protein Tyrosine Kinase Binding
	Biological Process	Protein Transport	Response To Reactive Oxygen Species Temperature Homeostasis Endothelial Cell Development Negative Regulation Of Inflammatory Response To Antigenic Stimulus Lipid Metabolic Process Triglyceride Metabolic Process Glutathione Metabolic Process Apoptotic Process Response To Oxidative Stress Sensory Perception Of Sound Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Response To Xenobiotic Stimulus Response To Symbiotic Bacterium Response To Wounding Response To Toxic Substance UV Protection Response To Hormone Response To Glucose Response To Selenium Ion Response To Gamma Radiation Myotube Differentiation Arachidonate Metabolic Process Lipoxygenase Pathway Response To Estradiol Response To Lipopolysaccharide Response To Hydroperoxide Response To Vitamin E Regulation Of Mammary Gland Epithelial Cell Proliferation Cellular Response To Oxidative Stress Response To Nicotine Epigenetic Regulation Of Gene Expression Vasodilation Response To Hydrogen Peroxide Hydrogen Peroxide Catabolic Process Skeletal Muscle Tissue Regeneration Blood Vessel Endothelial Cell Migration Fat Cell Differentiation Myoblast Differentiation Cell Redox Homeostasis Fibroblast Proliferation Skeletal Muscle Fiber Development Neuron Apoptotic Process Myoblast Proliferation Response To Folic Acid Biological Process Involved In Interaction With Symbiont Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Heart Contraction Angiogenesis Involved In Wound Healing Regulation Of Proteasomal Protein Catabolic Process Cellular Response To Glucose Stimulus Negative Regulation Of Release Of Cytochrome C From Mitochondria Cellular Oxidant Detoxification Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Supramolecular Fiber Organization
Pathways		None	Synthesis of 5-eicosatetraenoic acids Synthesis of 12-eicosatetraenoic acid derivatives Synthesis of 15-eicosatetraenoic acid derivatives Detoxification of Reactive Oxygen Species
Drugs		None	Glutathione Glutathione Glutathione disulfide Cannabidiol Benzoyl peroxide Medical Cannabis Nabiximols
Diseases		None	Anemia due to disorders of glutathione metabolism, including: Glucose-6-phosphate dehydrogenase (G6PD) deficiency; Glutathione peroxidase (GPX) deficiency; Gamma-glutamylcysteine synthetase (GCLC) deficiency; Glutathione synthetase (GSS) deficiency
GWAS		Blood trace element (Cu levels) ( 23720494 ) Lymphocyte count ( 32888494 ) Red cell distribution width ( 32888494 )	Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Crohn's disease ( 28067908 21102463 ) Extremely high intelligence ( 29520040 ) Hemoglobin levels ( 32327693 ) Household income (MTAG) ( 31844048 ) Inflammatory bowel disease ( 23128233 28067908 ) Intelligence (MTAG) ( 29326435 ) Mood instability ( 31168069 ) Sleep duration (short sleep) ( 30846698 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 ) Ulcerative colitis ( 28067908 25082827 )
Novel Interactors		2 novel interactors: DMBT1 WNT5A	10 novel interactors: ACKR2 CAMP CISH EBNA1BP2 IDH2 ITGA9 MLH1 MST1R RHOA UQCRC1
Interacting Genes		13 interacting genes: BARD1 EED GORASP2 GPX1 LRIF1 MED31 MLH1 MSRA POLDIP2 RPA1 TRA2A TRIP13 USP33	6 interacting genes: ABL1 ABL2 CFTR FAM9B MAPK6 SELENBP1
Entrez ID		8991	2876
HPRD ID		05007	11749
Ensembl ID		ENSG00000143416	ENSG00000233276
Uniprot IDs		Q13228 V9HWG1	A0A2R8Y6B6 P07203 Q7L4Q3
PDB IDs		Not available	2F8A
GO Terms Enriched among Interactors		Homologous Recombination Male Germ Cell Nucleus Cellular Response To Stress Response To Stress DNA Repair DNA Recombination Meiotic Nuclear Division Nuclear Division Meiotic Cell Cycle Reciprocal Meiotic Recombination DNA Metabolic Process Mismatch Repair Regulation Of Meiotic Nuclear Division DNA Damage Response Condensed Chromosome Negative Regulation Of MRNA 3'-end Processing Chromatin Organization Zymogen Binding Cell Development Double-strand Break Repair Male Meiotic Nuclear Division Condensed Nuclear Chromosome Oogenesis Late Recombination Nodule Meiotic Metaphase I Homologous Chromosome Alignment L-methionine:thioredoxin-disulfide S-oxidoreductase Activity Peptide-methionine (S)-S-oxide Reductase Activity L-methionine-(S)-S-oxide Reductase Activity Receptor Tyrosine Kinase-like Orphan Receptor Binding Chemoattraction Of Serotonergic Neuron Axon Negative Regulation Of Cell Proliferation In Midbrain Optic Cup Formation Involved In Camera-type Eye Development Chromosome Organization Involved In Meiotic Cell Cycle Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex Cellular Developmental Process Epigenetic Regulation Of Gene Expression Meiotic Spindle Midzone Assembly Female Gamete Generation Meiosis I Cell Cycle Process Meiotic Metaphase Chromosome Alignment Chiasma Regulation Of Meiotic Cell Cycle Postsynapse Assembly Hypophysis Morphogenesis Lateral Sprouting Involved In Mammary Gland Duct Morphogenesis Positive Regulation Of Timing Of Anagen Chemoattractant Activity Involved In Axon Guidance Cervix Development	Positive Regulation Of T Cell Migration Positive Regulation Of Establishment Of T Cell Polarity Regulation Of Establishment Of T Cell Polarity Positive Regulation Of Lymphocyte Migration Regulation Of T Cell Migration Enzyme Binding Regulation Of Vasoconstriction Regulation Of Lymphocyte Migration Enzyme Activator Activity Cellular Response To Lipid Positive Regulation Of Mononuclear Cell Migration Odontogenesis Regulation Of Modification Of Synaptic Structure Positive Regulation Of Lymphocyte Activation Regulation Of Establishment Of Cell Polarity Actin Monomer Binding Protein Tyrosine Kinase Activity Synaptonemal Complex Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Vessel Diameter Maintenance Regulation Of Osteoblast Proliferation Mismatch Repair Cell-substrate Adhesion Regulation Of Tube Size Regulation Of Establishment Or Maintenance Of Cell Polarity Regulation Of Mononuclear Cell Migration Positive Regulation Of Leukocyte Migration Positive Regulation Of Vasoconstriction Positive Regulation Of Cell Activation Nucleotide Binding Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Cellular Response To Lipopolysaccharide Response To Lipid Magnesium Ion Binding Cellular Response To Molecule Of Bacterial Origin Cellular Response To Oxygen-containing Compound Phosphotyrosine Residue Binding Substrate Adhesion-dependent Cell Spreading Protein Localization To Cytoplasmic Microtubule Plus-end Positive Regulation Of Developmental Process Immune System Process Non-membrane Spanning Protein Tyrosine Kinase Activity Angiotensin-mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Mitotic Cleavage Furrow Formation Prostaglandin Production Involved In Inflammatory Response Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Late Recombination Nodule Meiotic Metaphase I Homologous Chromosome Alignment