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KRT38 and PSMC5
Number of citations of the paper that reports this interaction (PMID
25416956
)
0
Data Source:
BioGRID
(two hybrid)
KRT38
PSMC5
Gene Name
keratin 38, type I
proteasome (prosome, macropain) 26S subunit, ATPase, 5
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Intermediate Filament
Extracellular Vesicular Exosome
Proteasome Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Proteasome Regulatory Particle
Membrane
Inclusion Body
Proteasome Accessory Complex
Cytoplasmic Vesicle
Nuclear Proteasome Complex
Cytosolic Proteasome Complex
Extracellular Vesicular Exosome
Blood Microparticle
Molecular Function
Structural Molecule Activity
Transcription Cofactor Activity
Protein Binding
ATP Binding
Transcription Factor Binding
ATPase Activity
TBP-class Protein Binding
Thyrotropin-releasing Hormone Receptor Binding
Biological Process
G1/S Transition Of Mitotic Cell Cycle
Protein Polyubiquitination
Mitotic Cell Cycle
Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
Transcription From RNA Polymerase II Promoter
Regulation Of Cellular Amino Acid Metabolic Process
Apoptotic Process
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Gene Expression
Viral Process
Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Cellular Nitrogen Compound Metabolic Process
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I
Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Negative Regulation Of Programmed Cell Death
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Small Molecule Metabolic Process
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition
Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Inclusion Body Assembly
Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways
Hedgehog 'off' state
misspliced GSK3beta mutants stabilize beta-catenin
Hh ligand biogenesis disease
T41 mutants of beta-catenin aren't phosphorylated
Downstream signaling events of B Cell Receptor (BCR)
Degradation of beta-catenin by the destruction complex
Stabilization of p53
S33 mutants of beta-catenin aren't phosphorylated
AXIN mutants destabilize the destruction complex, activating WNT signaling
Removal of licensing factors from origins
Switching of origins to a post-replicative state
Mitotic G1-G1/S phases
Regulation of mRNA stability by proteins that bind AU-rich elements
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
DNA Replication Pre-Initiation
S45 mutants of beta-catenin aren't phosphorylated
APC/C:Cdc20 mediated degradation of mitotic proteins
Regulation of APC/C activators between G1/S and early anaphase
SCF(Skp2)-mediated degradation of p27/p21
deletions in the AMER1 gene destabilize the destruction complex
Autodegradation of the E3 ubiquitin ligase COP1
AMER1 mutants destabilize the destruction complex
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
PCP/CE pathway
Adaptive Immune System
CDK-mediated phosphorylation and removal of Cdc6
Hedgehog ligand biogenesis
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Separation of Sister Chromatids
HIV Infection
Ubiquitin-dependent degradation of Cyclin D
APC truncation mutants have impaired AXIN binding
Assembly of the pre-replicative complex
Autodegradation of Cdh1 by Cdh1:APC/C
p53-Dependent G1 DNA Damage Response
S37 mutants of beta-catenin aren't phosphorylated
XAV939 inhibits tankyrase, stabilizing AXIN
p53-Independent DNA Damage Response
p53-Independent G1/S DNA damage checkpoint
G1/S DNA Damage Checkpoints
Vpu mediated degradation of CD4
Synthesis of DNA
M/G1 Transition
Ubiquitin-dependent degradation of Cyclin D1
TCF dependent signaling in response to WNT
SCF-beta-TrCP mediated degradation of Emi1
degradation of AXIN
Signaling by Hedgehog
Regulation of mitotic cell cycle
Degradation of GLI1 by the proteasome
degradation of DVL
Cell Cycle Checkpoints
Signaling by WNT in cancer
GLI3 is processed to GLI3R by the proteasome
Regulation of Apoptosis
Degradation of GLI2 by the proteasome
Signaling by the B Cell Receptor (BCR)
Vif-mediated degradation of APOBEC3G
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
p53-Dependent G1/S DNA damage checkpoint
truncated APC mutants destabilize the destruction complex
TCF7L2 mutants don't bind CTBP
Signaling by Wnt
Cyclin E associated events during G1/S transition
APC/C:Cdc20 mediated degradation of Securin
AUF1 (hnRNP D0) destabilizes mRNA
CDK-mediated phosphorylation and removal of Cdc6
RNF mutants show enhanced WNT signaling and proliferation
G1/S Transition
truncations of AMER1 destabilize the destruction complex
Processing-defective Hh variants abrogate ligand secretion
Host Interactions of HIV factors
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
Regulation of activated PAK-2p34 by proteasome mediated degradation
AXIN missense mutants destabilize the destruction complex
S Phase
APC/C-mediated degradation of cell cycle proteins
Cyclin A:Cdk2-associated events at S phase entry
SCF(Skp2)-mediated degradation of p27/p21
Mitotic Metaphase and Anaphase
Regulation of ornithine decarboxylase (ODC)
Antigen processing: Ubiquitination & Proteasome degradation
Orc1 removal from chromatin
Mitotic Anaphase
M Phase
APC truncation mutants are not K63 polyubiquitinated
Metabolism of amino acids and derivatives
Hedgehog 'on' state
Programmed Cell Death
Class I MHC mediated antigen processing & presentation
Regulation of DNA replication
Cell Cycle, Mitotic
beta-catenin independent WNT signaling
Orc1 removal from chromatin
Activation of NF-kappaB in B cells
Asymmetric localization of PCP proteins
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
Cross-presentation of soluble exogenous antigens (endosomes)
Antigen processing-Cross presentation
CDT1 association with the CDC6:ORC:origin complex
ER-Phagosome pathway
Drugs
Diseases
GWAS
Protein-Protein Interactions
45 interactors:
AMOTL2
ANKRD36BP1
BEX2
C19orf57
C1orf216
CCDC146
CD300A
CEP57L1
FAM90A1
GLRX3
GNG10
HAUS1
HDAC4
HGS
HMG20B
HOXA1
KDM1A
KLHL38
KRT2
KRT4
KRT5
KRT6A
KRT6B
KRT6C
KRT71
KRT79
KRT8
KRT81
KRT83
MAGEB4
PIK3R2
PIN1
PSMA1
PSMC5
PTGER3
RHPN1-AS1
SCNM1
TXLNA
TXLNB
TXNDC5
USHBP1
ZFYVE21
ZNF20
ZNF417
ZNF587
36 interactors:
CAMK2A
EPHA8
ERCC3
ESR1
FOS
GTF2B
HOMER3
HTT
INSIG2
KRT15
KRT38
KRT40
MDM2
MYO18B
NR1I2
NR1I3
PARK2
PDC
PDCL
PLEKHO1
PSMC3
PSMC4
RAD23A
RARA
RORA
RXRA
SP1
TAF10
THAP11
THRB
TNNT1
TP53
TRIP11
UBE3C
USP4
VDR
Entrez ID
8687
5705
HPRD ID
05176
03400
Ensembl ID
ENSG00000171360
ENSG00000087191
Uniprot IDs
O76015
P62195
PDB IDs
2KRK
3KW6
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of Ubiquitin-protein Transferase Activity
Positive Regulation Of Ligase Activity
Regulation Of Ubiquitin-protein Transferase Activity
Regulation Of Protein Sumoylation
Epidermis Development
Positive Regulation Of Protein Ubiquitination
Intermediate Filament Cytoskeleton Organization
Abducens Nerve Formation
Keratinocyte Activation
Negative Regulation Of NK T Cell Activation
Regulation Of Primitive Erythrocyte Differentiation
Optokinetic Behavior
Negative Regulation Of Activation Of JAK2 Kinase Activity
Negative Regulation Of Phagocytosis, Engulfment
Intermediate Filament-based Process
Tissue Development
Negative Regulation Of Intracellular Signal Transduction
Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Regulation Of Protein Ubiquitination
Transcription, DNA-templated
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint
Facial Nucleus Development
Negative Regulation Of Eosinophil Migration
Negative Regulation Of Eosinophil Activation
Epithelium Development
Negative Regulation Of Signal Transduction
Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition
Signal Transduction Involved In DNA Damage Checkpoint
Signal Transduction Involved In Cell Cycle Checkpoint
Cytoskeleton Organization
Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
RNA Biosynthetic Process
Negative Regulation Of Ubiquitin-protein Transferase Activity
Transcription Initiation From RNA Polymerase II Promoter
DNA-templated Transcription, Initiation
Transcription From RNA Polymerase II Promoter
Steroid Hormone Mediated Signaling Pathway
Cellular Response To Steroid Hormone Stimulus
Cellular Response To Organic Cyclic Compound
Hormone-mediated Signaling Pathway
Response To Steroid Hormone
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Gene Expression
Cellular Response To Lipid
Intracellular Receptor Signaling Pathway
Regulation Of Metabolic Process
Response To Lipid
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Cellular Metabolic Process
Response To Organic Cyclic Compound
Transcription, DNA-templated
Gene Expression
Response To Hormone
RNA Biosynthetic Process
Viral Process
Cellular Response To Hormone Stimulus
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Cellular Response To Organic Substance
Positive Regulation Of Cellular Biosynthetic Process
Regulation Of Nucleic Acid-templated Transcription
Positive Regulation Of Metabolic Process
Regulation Of RNA Biosynthetic Process
Regulation Of Nitrogen Compound Metabolic Process
Regulation Of RNA Metabolic Process
Cellular Nitrogen Compound Metabolic Process
RNA Metabolic Process
Response To Organic Substance
Regulation Of Gene Expression
Cellular Response To Stimulus
Nitrogen Compound Metabolic Process
Signaling
Negative Regulation Of Cellular Metabolic Process
Cell Communication
Signal Transduction
Regulation Of Transcription, DNA-templated
Heterocycle Metabolic Process
Cellular Metabolic Process
Female Pregnancy
Cellular Macromolecule Biosynthetic Process
Nucleobase-containing Compound Metabolic Process
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint
Tagcloud
?
11p11
12q15
17q23
19p13
19q13
20s
26s
7q22
atpases
charges
consitute
machine
modules
mss1
multisubunit
p42
pa700
proteasome
psmc1
psmc2
psmc3
psmc4
psmc6
q13
q22
q23
s4
tbp1
tbp7
Tagcloud (Difference)
?
11p11
12q15
17q23
19p13
19q13
20s
26s
7q22
atpases
charges
consitute
machine
modules
mss1
multisubunit
p42
pa700
proteasome
psmc1
psmc2
psmc3
psmc4
psmc6
q13
q22
q23
s4
tbp1
tbp7
Tagcloud (Intersection)
?