PSMC5 and CAMK2A

Number of citations of the paper that reports this interaction (PMID 22496558)
9

Data Source:
BioGRID (enzymatic study)

		PSMC5	CAMK2A
Gene Name		proteasome (prosome, macropain) 26S subunit, ATPase, 5	calcium/calmodulin-dependent protein kinase II alpha
Image
Gene Ontology Annotations	Cellular Component	Proteasome Complex Nucleus Nucleoplasm Cytoplasm Cytosol Proteasome Regulatory Particle Membrane Inclusion Body Proteasome Accessory Complex Cytoplasmic Vesicle Nuclear Proteasome Complex Cytosolic Proteasome Complex Extracellular Vesicular Exosome Blood Microparticle	Nucleus Nucleoplasm Mitochondrion Cytosol Plasma Membrane Cell Junction Endocytic Vesicle Membrane Presynaptic Membrane
	Molecular Function	Transcription Cofactor Activity Protein Binding ATP Binding Transcription Factor Binding ATPase Activity TBP-class Protein Binding Thyrotropin-releasing Hormone Receptor Binding	Protein Serine/threonine Kinase Activity Calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding Kinase Activity Glutamate Receptor Binding Protein Homodimerization Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Protein Polyubiquitination Mitotic Cell Cycle Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Transcription From RNA Polymerase II Promoter Regulation Of Cellular Amino Acid Metabolic Process Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Gene Expression Viral Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Nitrogen Compound Metabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Small Molecule Metabolic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Inclusion Body Assembly Positive Regulation Of Canonical Wnt Signaling Pathway	G1/S Transition Of Mitotic Cell Cycle Response To Ischemia Protein Phosphorylation Calcium Ion Transport Synaptic Transmission Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Peptidyl-serine Phosphorylation Cytokine-mediated Signaling Pathway Cellular Response To Heat Protein Autophosphorylation Regulation Of Neurotransmitter Secretion Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Calcium Ion Transport Interferon-gamma-mediated Signaling Pathway Regulation Of Cellular Response To Heat Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process
Pathways		Hedgehog 'off' state misspliced GSK3beta mutants stabilize beta-catenin Hh ligand biogenesis disease T41 mutants of beta-catenin aren't phosphorylated Downstream signaling events of B Cell Receptor (BCR) Degradation of beta-catenin by the destruction complex Stabilization of p53 S33 mutants of beta-catenin aren't phosphorylated AXIN mutants destabilize the destruction complex, activating WNT signaling Removal of licensing factors from origins Switching of origins to a post-replicative state Mitotic G1-G1/S phases Regulation of mRNA stability by proteins that bind AU-rich elements misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling DNA Replication Pre-Initiation S45 mutants of beta-catenin aren't phosphorylated APC/C:Cdc20 mediated degradation of mitotic proteins Regulation of APC/C activators between G1/S and early anaphase SCF(Skp2)-mediated degradation of p27/p21 deletions in the AMER1 gene destabilize the destruction complex Autodegradation of the E3 ubiquitin ligase COP1 AMER1 mutants destabilize the destruction complex Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint PCP/CE pathway Adaptive Immune System CDK-mediated phosphorylation and removal of Cdc6 Hedgehog ligand biogenesis APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Separation of Sister Chromatids HIV Infection Ubiquitin-dependent degradation of Cyclin D APC truncation mutants have impaired AXIN binding Assembly of the pre-replicative complex Autodegradation of Cdh1 by Cdh1:APC/C p53-Dependent G1 DNA Damage Response S37 mutants of beta-catenin aren't phosphorylated XAV939 inhibits tankyrase, stabilizing AXIN p53-Independent DNA Damage Response p53-Independent G1/S DNA damage checkpoint G1/S DNA Damage Checkpoints Vpu mediated degradation of CD4 Synthesis of DNA M/G1 Transition Ubiquitin-dependent degradation of Cyclin D1 TCF dependent signaling in response to WNT SCF-beta-TrCP mediated degradation of Emi1 degradation of AXIN Signaling by Hedgehog Regulation of mitotic cell cycle Degradation of GLI1 by the proteasome degradation of DVL Cell Cycle Checkpoints Signaling by WNT in cancer GLI3 is processed to GLI3R by the proteasome Regulation of Apoptosis Degradation of GLI2 by the proteasome Signaling by the B Cell Receptor (BCR) Vif-mediated degradation of APOBEC3G Ubiquitin Mediated Degradation of Phosphorylated Cdc25A p53-Dependent G1/S DNA damage checkpoint truncated APC mutants destabilize the destruction complex TCF7L2 mutants don't bind CTBP Signaling by Wnt Cyclin E associated events during G1/S transition APC/C:Cdc20 mediated degradation of Securin AUF1 (hnRNP D0) destabilizes mRNA CDK-mediated phosphorylation and removal of Cdc6 RNF mutants show enhanced WNT signaling and proliferation G1/S Transition truncations of AMER1 destabilize the destruction complex Processing-defective Hh variants abrogate ligand secretion Host Interactions of HIV factors phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex Regulation of activated PAK-2p34 by proteasome mediated degradation AXIN missense mutants destabilize the destruction complex S Phase APC/C-mediated degradation of cell cycle proteins Cyclin A:Cdk2-associated events at S phase entry SCF(Skp2)-mediated degradation of p27/p21 Mitotic Metaphase and Anaphase Regulation of ornithine decarboxylase (ODC) Antigen processing: Ubiquitination & Proteasome degradation Orc1 removal from chromatin Mitotic Anaphase M Phase APC truncation mutants are not K63 polyubiquitinated Metabolism of amino acids and derivatives Hedgehog 'on' state Programmed Cell Death Class I MHC mediated antigen processing & presentation Regulation of DNA replication Cell Cycle, Mitotic beta-catenin independent WNT signaling Orc1 removal from chromatin Activation of NF-kappaB in B cells Asymmetric localization of PCP proteins deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Cross-presentation of soluble exogenous antigens (endosomes) Antigen processing-Cross presentation CDT1 association with the CDC6:ORC:origin complex ER-Phagosome pathway	Interferon Signaling Cytokine Signaling in Immune system Cellular response to heat stress Signaling by Wnt CREB phosphorylation through the activation of Ras Trafficking of AMPA receptors beta-catenin independent WNT signaling Interferon gamma signaling HSF1-dependent transactivation Ca2+ pathway Activation of NMDA receptor upon glutamate binding and postsynaptic events CREB phosphorylation through the activation of CaMKII Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity Unblocking of NMDA receptor, glutamate binding and activation Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Ras activation uopn Ca2+ infux through NMDA receptor Post NMDA receptor activation events Transmission across Chemical Synapses
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661)
Protein-Protein Interactions		36 interactors: CAMK2A EPHA8 ERCC3 ESR1 FOS GTF2B HOMER3 HTT INSIG2 KRT15 KRT38 KRT40 MDM2 MYO18B NR1I2 NR1I3 PARK2 PDC PDCL PLEKHO1 PSMC3 PSMC4 RAD23A RARA RORA RXRA SP1 TAF10 THAP11 THRB TNNT1 TP53 TRIP11 UBE3C USP4 VDR	40 interactors: ACTN1 ACTN2 ACTN4 ATF1 ATP2A2 CAMK2N2 CDK5R1 CDK5R2 CEBPB CHAT CREB1 DAPK2 DLG1 EGFR ETS1 GFAP GRIN1 GRIN2A GRIN2B HSF1 ITGA2B ITGB1BP1 ITPKA KRT18 LRRC7 MAPT MPDZ NOS1 PDC PPM1F PSMC5 PTTG1 RCHY1 RIMS1 SMAD2 SQSTM1 SRF SYNGAP1 TANC1 YWHAB
Entrez ID		5705	815
HPRD ID		03400	06532
Ensembl ID		ENSG00000087191	ENSG00000070808
Uniprot IDs		P62195	A8K161 Q7LDD5 Q8IWE0 Q9UQM7
PDB IDs		2KRK 3KW6	2VZ6 3SOA
Enriched GO Terms of Interacting Partners?		Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Transcription From RNA Polymerase II Promoter Steroid Hormone Mediated Signaling Pathway Cellular Response To Steroid Hormone Stimulus Cellular Response To Organic Cyclic Compound Hormone-mediated Signaling Pathway Response To Steroid Hormone Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Cellular Response To Lipid Intracellular Receptor Signaling Pathway Regulation Of Metabolic Process Response To Lipid Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Response To Organic Cyclic Compound Transcription, DNA-templated Gene Expression Response To Hormone RNA Biosynthetic Process Viral Process Cellular Response To Hormone Stimulus Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Organic Substance Positive Regulation Of Cellular Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Response To Organic Substance Regulation Of Gene Expression Cellular Response To Stimulus Nitrogen Compound Metabolic Process Signaling Negative Regulation Of Cellular Metabolic Process Cell Communication Signal Transduction Regulation Of Transcription, DNA-templated Heterocycle Metabolic Process Cellular Metabolic Process Female Pregnancy Cellular Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint	Regulation Of Synaptic Transmission Cell Projection Organization Neurogenesis Nervous System Development Anatomical Structure Development Generation Of Neurons Cell Differentiation Developmental Process Response To Stimulus Regulation Of Synaptic Plasticity Neuron Projection Development Regulation Of Apoptotic Process Locomotion Regulation Of Cell Death Neuron Differentiation Regulation Of Signaling Regulation Of Cellular Process Neuron Development Single-organism Behavior Regulation Of Cellular Component Organization Positive Regulation Of Cellular Metabolic Process Cell Communication Pons Maturation Movement Of Cell Or Subcellular Component Regulation Of Metabolic Process Positive Regulation Of Gene Expression System Development Positive Regulation Of Metabolic Process Learning Or Memory Cellular Response To Stimulus Signaling Cognition Behavior Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Stress Anatomical Structure Morphogenesis Response To External Stimulus Positive Regulation Of Transcription, DNA-templated Multicellular Organismal Development Response To Abiotic Stimulus Learning Regulation Of Cellular Component Movement Response To Wounding Axonogenesis Regulation Of Neuron Projection Development Cell Morphogenesis Involved In Differentiation Positive Regulation Of Transport Axon Guidance Axon Development Regulation Of Membrane Potential
Tagcloud ?		11p11 12q15 17q23 19p13 19q13 20s 26s 7q22 atpases charges consitute machine modules mss1 multisubunit p42 pa700 proteasome psmc1 psmc2 psmc3 psmc4 psmc6 q13 q22 q23 s4 tbp1 tbp7	acquiring ca1 collecting combines conditioning crossing doxycycline egfp enables epitope fear identities integrates introduce l10a offspring pyramidal ribosomal ribosome ribosomes spiny striatum tagged teto tetracycline transactivator transgene translating tta
Tagcloud (Difference) ?		11p11 12q15 17q23 19p13 19q13 20s 26s 7q22 atpases charges consitute machine modules mss1 multisubunit p42 pa700 proteasome psmc1 psmc2 psmc3 psmc4 psmc6 q13 q22 q23 s4 tbp1 tbp7	acquiring ca1 collecting combines conditioning crossing doxycycline egfp enables epitope fear identities integrates introduce l10a offspring pyramidal ribosomal ribosome ribosomes spiny striatum tagged teto tetracycline transactivator transgene translating tta
Tagcloud (Intersection) ?