KRT38 and LMO4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KRT38	LMO4
Description		keratin 38	LIM domain only 4
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Cytoskeleton Intermediate Filament Keratin Filament Extracellular Exosome	Nucleus Transcription Regulator Complex Cell Leading Edge RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Structural Molecule Activity Protein Binding Structural Constituent Of Skin Epidermis	Transcription Coregulator Activity Transcription Corepressor Activity Protein Binding Metal Ion Binding DNA-binding Transcription Factor Binding
	Biological Process	Morphogenesis Of An Epithelium Epithelial Cell Differentiation Intermediate Filament Organization	Negative Regulation Of Transcription By RNA Polymerase II Neural Tube Closure Ventricular Septum Development Regulation Of Transcription By RNA Polymerase II Motor Neuron Axon Guidance Tissue Development Ventral Spinal Cord Interneuron Differentiation Spinal Cord Motor Neuron Cell Fate Specification Spinal Cord Motor Neuron Differentiation Spinal Cord Association Neuron Differentiation Regulation Of Cell Migration Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Kinase Activity Regulation Of Cell Fate Specification Positive Regulation Of Transcription By RNA Polymerase II Thymus Development Regulation Of Developmental Process Regulation Of Cell Activation
Pathways		Keratinization Formation of the cornified envelope
Drugs
Diseases
GWAS			Academic attainment (English) ( 33594131) Age at first sexual intercourse ( 34211149) Alanine aminotransferase levels ( 33547301) Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Aspartate aminotransferase levels ( 33547301) Breast cancer ( 27354352) Eosinophil count ( 29403010) Gait rhythm ( 26219847) Glaucoma (primary open-angle) ( 29891935) Photic sneeze reflex ( 27182965) Prostate-specific antigen levels ( 28139693) Response to TNF antagonist treatment ( 18615156) Resting heart rate ( 27798624) White blood cell count (basophil) ( 29403010) White blood cell types ( 21738478)
Interacting Genes		72 interacting genes: - ABI3 AMOTL2 ANKRD36BP1 BEX2 BRME1 C1orf216 CCDC120 CCDC146 CD300A CEP57L1 DMRT3 DTNB FAM110A FAM90A1 GLRX3 GNG10 GNG13 HAUS1 HDAC4 HGS HMG20B HOXA1 HSF4 KDM1A KIFC3 KLHL38 KRT1 KRT2 KRT3 KRT4 KRT5 KRT6A KRT6B KRT6C KRT71 KRT72 KRT74 KRT75 KRT76 KRT78 KRT79 KRT8 KRT80 KRT81 KRT83 KRT86 LHX4 LMO3 LMO4 MAGEB4 MAPKBP1 PIK3R2 PIN1 POU4F2 PSMA1 PSMC5 PTGER3 RHPN1-AS1 SCNM1 SMARCD1 TBC1D21 TRIML2 TXLNA TXLNB TXNDC5 USHBP1 UTP23 ZFYVE21 ZNF20 ZNF417 ZNF587	131 interacting genes: AARD ABI2 ADAMTSL4 AMOT AMOTL2 ARNT2 BANP BBS2 BCAS2 BIRC7 BRCA1 CALCOCO2 CCDC102B CCDC120 CEP170P1 COG6 CRNN CRYBB2 CSNK2B CTBP2 CYSRT1 DDB1 DEAF1 DES ECM1 ERCC6L EXOSC8 FAM228A FHL3 GABPB1 GADD45A GOLGA2 GOLGA6L9 GRHL2 GSK3B HELT HGS HSF2BP ID3 IKZF1 IKZF3 ITSN1 KANK2 KATNBL1 KIAA1958 KIF3B KPNA1 KRT15 KRT31 KRT33B KRT34 KRT38 KRT39 KRT40 KRT74 KRT75 KRT76 KRTAP11-1 KRTAP3-1 KYNU L3MBTL3 LASP1 LDB1 LDB2 LMO2 LZTS1 MCCD1 MERTK METTL27 MID2 MTA1 MTUS2 MYOD1 MYOZ3 N4BP3 NFKBID NFYC NHLH1 NME4 NONO NRF1 PDE4DIP PELO PER2 PITPNB PLK1 PPARG QRICH1 RBAK RBBP8 RBPMS RCN1 REDIC1 RLIM RNF8 ROPN1 RPS6KA6 RSPH6A SAXO4 SEC24D SLC15A2 SMAD4 SMAD9 STAT5B SUOX TCF21 TCF4 TEX14 TFIP11 TINAGL1 TLE5 TNFSF11 TP53BP2 TRAF5 TRIM27 TRIM54 TSEN15 TTLL7 UBQLN2 VMAC VPS52 WASHC1 ZBTB43 ZMYND12 ZNF135 ZNF202 ZNF213 ZNF397 ZNF410 ZNF467 ZNF675
Entrez ID		8687	8543
HPRD ID		05176	09122
Ensembl ID		ENSG00000171360	ENSG00000143013
Uniprot IDs		O76015	P61968
PDB IDs			9F5B
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Skin Epidermis Keratinization Intermediate Filament Organization Keratin Filament Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Supramolecular Fiber Organization Organelle Organization Protein Binding Extracellular Exosome Intermediate Filament Cytoskeleton Epidermis Development	Protein Binding Intermediate Filament Organization Keratin Filament Structural Constituent Of Skin Epidermis Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Cytoskeleton Organization Intermediate Filament Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Identical Protein Binding Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Structural Molecule Activity Supramolecular Fiber Organization RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Primary Metabolic Process Organelle Organization Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Transcription Regulator Complex Developmental Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Cytoskeleton Regulation Of Metabolic Process DNA Binding Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Biosynthetic Process Epithelial Cell Differentiation RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Centrosome Cycle Positive Regulation Of RNA Metabolic Process Microtubule-based Process Microtubule Cytoskeleton Organization DNA-binding Transcription Factor Activity BHLH Transcription Factor Binding Positive Regulation Of Transcription By RNA Polymerase II Protein Dimerization Activity RNA Polymerase II Transcription Regulator Complex
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