KRT38 and TXNDC5

Number of citations of the paper that reports this interaction (PubMedID 29892012)
71

Data Source:
BioGRID (two hybrid, two hybrid)

		KRT38	TXNDC5
Description		keratin 38	thioredoxin domain containing 5
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Cytoskeleton Intermediate Filament Keratin Filament Extracellular Exosome	Extracellular Region Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endomembrane System Azurophil Granule Lumen Lysosomal Lumen Intracellular Organelle Lumen Extracellular Exosome
	Molecular Function	Structural Molecule Activity Protein Binding Structural Constituent Of Skin Epidermis	Protein Disulfide Isomerase Activity Protein Binding Protein-disulfide Reductase Activity Oxidoreductase Activity Isomerase Activity
	Biological Process	Morphogenesis Of An Epithelium Epithelial Cell Differentiation Intermediate Filament Organization	Protein Folding Negative Regulation Of Apoptotic Process
Pathways		Keratinization Formation of the cornified envelope	Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Neutrophil degranulation
Drugs
Diseases
GWAS			Blood protein levels ( 30072576) High chromosomal aberration frequency (chromatid type) ( 31586183) Mean corpuscular hemoglobin ( 32888494) Pelvic organ prolapse ( 32184442)
Interacting Genes		72 interacting genes: - ABI3 AMOTL2 ANKRD36BP1 BEX2 BRME1 C1orf216 CCDC120 CCDC146 CD300A CEP57L1 DMRT3 DTNB FAM110A FAM90A1 GLRX3 GNG10 GNG13 HAUS1 HDAC4 HGS HMG20B HOXA1 HSF4 KDM1A KIFC3 KLHL38 KRT1 KRT2 KRT3 KRT4 KRT5 KRT6A KRT6B KRT6C KRT71 KRT72 KRT74 KRT75 KRT76 KRT78 KRT79 KRT8 KRT80 KRT81 KRT83 KRT86 LHX4 LMO3 LMO4 MAGEB4 MAPKBP1 PIK3R2 PIN1 POU4F2 PSMA1 PSMC5 PTGER3 RHPN1-AS1 SCNM1 SMARCD1 TBC1D21 TRIML2 TXLNA TXLNB TXNDC5 USHBP1 UTP23 ZFYVE21 ZNF20 ZNF417 ZNF587	29 interacting genes: APP AR BLZF1 CEBPA EDEM3 EFEMP1 FLACC1 GMPPB KRT38 KRT40 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP4-12 KRTAP4-2 LHX4 MGAT5B NOTCH2NLA OGT PJA1 PRDX2 RAB3IP SPRY2 TRIM23 TRIM42 TRIP6 UBQLN2
Entrez ID		8687	81567
HPRD ID		05176	18249
Ensembl ID		ENSG00000171360	ENSG00000239264
Uniprot IDs		O76015	A0A024QZV0 Q8NBS9
PDB IDs			2DIZ 3UJ1 3UVT 3WGD 3WGE 3WGX 8EKY
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Skin Epidermis Keratinization Intermediate Filament Organization Keratin Filament Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Supramolecular Fiber Organization Organelle Organization Protein Binding Extracellular Exosome Intermediate Filament Cytoskeleton Epidermis Development	Keratin Filament Intermediate Filament Protein Glycosylation Macromolecule Glycosylation Glycosylation Hair Cycle
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