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PSMC5 and PSMC4
Number of citations of the paper that reports this interaction (PubMedID
16189514
)
0
Data Source:
HPRD
(two hybrid)
PSMC5
PSMC4
Description
proteasome 26S subunit, ATPase 5
proteasome 26S subunit, ATPase 4
Image
GO Annotations
Cellular Component
Proteasome Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Proteasome Regulatory Particle
Proteasome Regulatory Particle, Base Subcomplex
Membrane
Inclusion Body
Proteasome Accessory Complex
Cytoplasmic Vesicle
Nuclear Proteasome Complex
Cytosolic Proteasome Complex
Extracellular Exosome
Blood Microparticle
Proteasome Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Proteasome Regulatory Particle, Base Subcomplex
Membrane
Proteasome Accessory Complex
Ciliary Basal Body
Molecular Function
Nucleotide Binding
Signaling Receptor Binding
Protein Binding
ATP Binding
Transcription Factor Binding
ATP Hydrolysis Activity
TBP-class Protein Binding
Thyrotropin-releasing Hormone Receptor Binding
Proteasome-activating Activity
General Transcription Initiation Factor Binding
DNA-binding Transcription Factor Binding
Nucleotide Binding
Protein Binding
ATP Binding
ATP Hydrolysis Activity
Proteasome-activating Activity
Biological Process
Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Programmed Cell Death
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Inclusion Body Assembly
Positive Regulation Of Proteasomal Protein Catabolic Process
Blastocyst Development
Proteolysis
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Proteasomal Protein Catabolic Process
Pathways
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
ER-Phagosome pathway
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Vpu mediated degradation of CD4
Vif-mediated degradation of APOBEC3G
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Regulation of activated PAK-2p34 by proteasome mediated degradation
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Hedgehog ligand biogenesis
Hh mutants are degraded by ERAD
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog 'on' state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
Defective CFTR causes cystic fibrosis
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
Assembly of the pre-replicative complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
G2/M Checkpoints
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A
Ubiquitin-dependent degradation of Cyclin D
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Regulation of expression of SLITs and ROBOs
Interleukin-1 signaling
Negative regulation of NOTCH4 signaling
KEAP1-NFE2L2 pathway
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2
Degradation of CDH1
Somitogenesis
Antigen processing: Ubiquitination & Proteasome degradation
Proteasome assembly
Proteasome assembly
GSK3B-mediated proteasomal degradation of PD-L1(CD274)
SPOP-mediated proteasomal degradation of PD-L1(CD274)
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)
Degradation of CRY and PER proteins
Degradation of CRY and PER proteins
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
ER-Phagosome pathway
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Vpu mediated degradation of CD4
Vif-mediated degradation of APOBEC3G
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Regulation of activated PAK-2p34 by proteasome mediated degradation
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Hedgehog ligand biogenesis
Hh mutants are degraded by ERAD
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog 'on' state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
Defective CFTR causes cystic fibrosis
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
Assembly of the pre-replicative complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
G2/M Checkpoints
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A
Ubiquitin-dependent degradation of Cyclin D
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Regulation of expression of SLITs and ROBOs
Interleukin-1 signaling
Negative regulation of NOTCH4 signaling
KEAP1-NFE2L2 pathway
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2
Degradation of CDH1
Somitogenesis
Antigen processing: Ubiquitination & Proteasome degradation
Proteasome assembly
Proteasome assembly
GSK3B-mediated proteasomal degradation of PD-L1(CD274)
SPOP-mediated proteasomal degradation of PD-L1(CD274)
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)
Degradation of CRY and PER proteins
Degradation of CRY and PER proteins
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Drugs
Diseases
GWAS
Interacting Genes
75 interacting genes:
AKT1
AZIN2
BACH2
BFSP2
CAMK2A
CCDC136
CDC42
CFAP206
EPHA8
ERCC3
ERCC6
ESR1
ESR2
ESRRA
ESRRG
FOS
FXR1
GTF2B
HARS1
HNF4G
HOMER3
HSPA1A
HTT
INSIG2
KRT15
KRT27
KRT31
KRT38
KRT40
LAMB1
MDM2
MYO18B
NR1H3
NR1I2
NR1I3
NR3C2
OGT
PDC
PDCL
PLEKHO1
PPARD
PRKN
PSMC3
PSMC4
RAD23A
RARA
RARB
RARG
RORA
RORB
RORC
RXRA
SCOC
SHOC2
SIRPA
SKA1
SP1
SSNA1
SUMO2
TAF10
TFIP11
THAP11
THRB
TNNI2
TNNI3
TNNT1
TP53
TPM1
TRIP11
UBE3C
UBLCP1
USP4
VDR
VIM
XPC
17 interacting genes:
CEBPA
FILNC1
NPM1
NR1I3
OGT
PAAF1
PSMC2
PSMC3
PSMC5
PSMD10
RNF2
RORB
SUMO2
TRAP1
UBASH3A
UBLCP1
ZFAND1
Entrez ID
5705
5704
HPRD ID
03400
04085
Ensembl ID
ENSG00000087191
ENSG00000013275
Uniprot IDs
A0A140VJS3
P62195
A8K2M0
P43686
PDB IDs
2KRK
3KW6
5GJQ
5GJR
5L4G
5LN3
5M32
5T0C
5T0G
5T0H
5T0I
5T0J
5VFP
5VFQ
5VFR
5VFS
5VFT
5VFU
5VGZ
5VHF
5VHH
5VHI
5VHJ
5VHM
5VHN
5VHO
5VHP
5VHQ
5VHR
5VHS
6MSB
6MSD
6MSG
6MSH
6MSJ
6MSK
6WJD
6WJN
7QXN
7QXP
7QXU
7QXW
7QXX
7QY7
7QYA
7QYB
7W37
7W38
7W39
7W3A
7W3B
7W3C
7W3F
7W3G
7W3H
7W3I
7W3J
7W3K
7W3M
8CVT
8JRI
8JRT
8JTI
8K0G
8USB
8USC
9E8G
9E8H
9E8I
9E8J
9E8K
9E8L
9E8N
9E8O
9E8Q
2DVW
5GJQ
5GJR
5L4G
5LN3
5M32
5T0C
5T0G
5T0H
5T0I
5T0J
5VFP
5VFQ
5VFR
5VFS
5VFT
5VFU
5VGZ
5VHF
5VHH
5VHI
5VHJ
5VHM
5VHN
5VHO
5VHP
5VHQ
5VHR
5VHS
6MSB
6MSD
6MSE
6MSG
6MSH
6MSJ
6MSK
6WJD
6WJN
7QXN
7QXP
7QXU
7QXW
7QXX
7QY7
7QYA
7QYB
7W37
7W38
7W39
7W3A
7W3B
7W3C
7W3F
7W3G
7W3H
7W3I
7W3J
7W3K
7W3M
8CVT
8JRI
8JRT
8JTI
8K0G
8USB
8USC
9E8G
9E8H
9E8I
9E8J
9E8K
9E8L
9E8N
9E8O
9E8Q
Enriched GO Terms of Interacting Partners
?
Nuclear Receptor Activity
Intracellular Receptor Signaling Pathway
Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity
Nuclear Receptor-mediated Signaling Pathway
Nuclear Steroid Receptor Activity
Hormone-mediated Signaling Pathway
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Metabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
Intracellular Signal Transduction
Cell Differentiation
Positive Regulation Of Metabolic Process
Positive Regulation Of Biosynthetic Process
Chromatin
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Cellular Developmental Process
Retinoic Acid Receptor Signaling Pathway
Developmental Process
RNA Polymerase II Transcription Regulator Complex
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Nucleoplasm
Positive Regulation Of Macromolecule Metabolic Process
Cellular Response To Oxygen-containing Compound
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
Sequence-specific Double-stranded DNA Binding
Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Estrogen Response Element Binding
Regulation Of RNA Metabolic Process
Regulation Of DNA-templated Transcription
Nucleus
Response To Lipid
Regulation Of RNA Biosynthetic Process
Steroid Hormone Receptor Signaling Pathway
Nuclear Receptor-mediated Steroid Hormone Signaling Pathway
Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of RNA Metabolic Process
DNA Binding
Transcription By RNA Polymerase II
MRNA Transcription
Regulation Of Primary Metabolic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Cellular Response To Hormone Stimulus
Intermediate Filament Organization
Positive Regulation Of Proteasomal Protein Catabolic Process
Positive Regulation Of Proteolysis
Regulation Of Proteasomal Protein Catabolic Process
Proteasome Regulatory Particle, Base Subcomplex
Positive Regulation Of Proteasomal Protein Catabolic Process
Positive Regulation Of Proteolysis Involved In Protein Catabolic Process
Proteasome Complex
Proteasome-activating Activity
Regulation Of Protein Catabolic Process
Positive Regulation Of Protein Catabolic Process
Regulation Of Proteolysis
Positive Regulation Of Protein Metabolic Process
Proteasome Accessory Complex
Regulation Of Protein Metabolic Process
Nucleoplasm
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Catabolic Process
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of RNA Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Negative Regulation Of Biosynthetic Process
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of RNA Metabolic Process
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Gene Expression
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Primary Metabolic Process
ATP Hydrolysis Activity
Regulation Of RNA Metabolic Process
Positive Regulation Of Metabolic Process
Negative Regulation Of Metabolic Process
Regulation Of Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
DNA-binding Transcription Factor Binding
Regulation Of Nucleobase-containing Compound Metabolic Process
Macrophage Differentiation
RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding
Regulation Of MRNA Stability Involved In Cellular Response To UV
Regulation Of EIF2 Alpha Phosphorylation By DsRNA
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