KRT38 and GNG10

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		KRT38	GNG10
Gene Name		keratin 38, type I	guanine nucleotide binding protein (G protein), gamma 10
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Intermediate Filament Extracellular Vesicular Exosome	Heterotrimeric G-protein Complex Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Structural Molecule Activity	GTPase Activity Signal Transducer Activity
	Biological Process		Energy Reserve Metabolic Process Signal Transduction G-protein Coupled Receptor Signaling Pathway Synaptic Transmission Small Molecule Metabolic Process Cellular Response To Glucagon Stimulus
Pathways			Signaling by GPCR Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 1 Integration of energy metabolism G alpha (s) signalling events Activation of GABAB receptors Glucagon-type ligand receptors G beta:gamma signalling through PLC beta Signaling by Wnt Metabolic disorders of biological oxidation enzymes G protein gated Potassium channels Gastrin-CREB signalling pathway via PKC and MAPK Thromboxane signalling through TP receptor G alpha (z) signalling events G alpha (i) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell ADP signalling through P2Y purinoceptor 12 Glucagon signaling in metabolic regulation Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits Inwardly rectifying K+ channels G-protein beta:gamma signalling Opioid Signalling Activation of Kainate Receptors upon glutamate binding Aquaporin-mediated transport Adrenaline,noradrenaline inhibits insulin secretion G alpha (q) signalling events GPCR downstream signaling Platelet homeostasis Platelet activation, signaling and aggregation Transmission across Chemical Synapses G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signal amplification Potassium Channels G beta:gamma signalling through PI3Kgamma G alpha (12/13) signalling events Class B/2 (Secretin family receptors) Prostacyclin signalling through prostacyclin receptor GABA B receptor activation GABA receptor activation Activation of G protein gated Potassium channels Vasopressin regulates renal water homeostasis via Aquaporins Regulation of insulin secretion GPCR ligand binding beta-catenin independent WNT signaling Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Ca2+ pathway G-protein activation
Drugs
Diseases
GWAS
Protein-Protein Interactions		45 interactors: AMOTL2 ANKRD36BP1 BEX2 C19orf57 C1orf216 CCDC146 CD300A CEP57L1 FAM90A1 GLRX3 GNG10 HAUS1 HDAC4 HGS HMG20B HOXA1 KDM1A KLHL38 KRT2 KRT4 KRT5 KRT6A KRT6B KRT6C KRT71 KRT79 KRT8 KRT81 KRT83 MAGEB4 PIK3R2 PIN1 PSMA1 PSMC5 PTGER3 RHPN1-AS1 SCNM1 TXLNA TXLNB TXNDC5 USHBP1 ZFYVE21 ZNF20 ZNF417 ZNF587	7 interactors: GNB1 GNB2 GNB3 GNB4 KRT31 KRT38 TCF4
Entrez ID		8687	2790
HPRD ID		05176	10374
Ensembl ID		ENSG00000171360	ENSG00000242616
Uniprot IDs		O76015	P50151
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Sumoylation Epidermis Development Positive Regulation Of Protein Ubiquitination Intermediate Filament Cytoskeleton Organization Abducens Nerve Formation Keratinocyte Activation Negative Regulation Of NK T Cell Activation Regulation Of Primitive Erythrocyte Differentiation Optokinetic Behavior Negative Regulation Of Activation Of JAK2 Kinase Activity Negative Regulation Of Phagocytosis, Engulfment Intermediate Filament-based Process Tissue Development Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of Protein Ubiquitination Transcription, DNA-templated DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Facial Nucleus Development Negative Regulation Of Eosinophil Migration Negative Regulation Of Eosinophil Activation Epithelium Development Negative Regulation Of Signal Transduction Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Cytoskeleton Organization Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle RNA Biosynthetic Process Negative Regulation Of Ubiquitin-protein Transferase Activity	Energy Reserve Metabolic Process Cellular Response To Glucagon Stimulus Response To Glucagon Energy Derivation By Oxidation Of Organic Compounds Generation Of Precursor Metabolites And Energy Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Peptide Cellular Response To Hormone Stimulus Oxidation-reduction Process Response To Organonitrogen Compound Response To Hormone Response To Organic Substance Synaptic Transmission Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Catenin Import Into Nucleus Cellular Response To Organic Substance Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Maintenance Of DNA Repeat Elements Cell-cell Signaling Small Molecule Metabolic Process Embryonic Hindgut Morphogenesis Negative Regulation Of Type B Pancreatic Cell Apoptotic Process Embryonic Genitalia Morphogenesis Cardiac Muscle Cell Apoptotic Process Myoblast Fate Commitment Muscle Cell Apoptotic Process G-protein Coupled Receptor Signaling Pathway Secretory Granule Localization Signal Transduction Hindgut Morphogenesis Insulin Metabolic Process Hindgut Development Cellular Response To Prostaglandin E Stimulus Positive Regulation Of Protein Export From Nucleus G-protein Coupled Acetylcholine Receptor Signaling Pathway Positive Regulation Of Glycoprotein Biosynthetic Process Cell Surface Receptor Signaling Pathway Signaling Positive Regulation Of Triglyceride Biosynthetic Process Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Cell Communication Positive Regulation Of Glycoprotein Metabolic Process Positive Regulation Of Gluconeogenesis Regulation Of Triglyceride Biosynthetic Process Genitalia Morphogenesis Cellular Response To Prostaglandin Stimulus Response To Prostaglandin E
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