PSMC5 and RARB

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		PSMC5	RARB
Name		proteasome 26S subunit, ATPase 5	retinoic acid receptor beta
Structure
GO Annotations	Cellular Component	Proteasome Complex Nucleus Nucleoplasm Cytoplasm Cytosol Proteasome Regulatory Particle Proteasome Regulatory Particle, Base Subcomplex Membrane Inclusion Body Proteasome Accessory Complex Cytoplasmic Vesicle Nuclear Proteasome Complex Cytosolic Proteasome Complex Extracellular Exosome Blood Microparticle	Chromatin Nucleus Nucleoplasm Cytoplasm RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Nucleotide Binding Signaling Receptor Binding Protein Binding ATP Binding Transcription Factor Binding ATP Hydrolysis Activity TBP-class Protein Binding Thyrotropin-releasing Hormone Receptor Binding Proteasome-activating Activity General Transcription Initiation Factor Binding DNA-binding Transcription Factor Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Protein-containing Complex Binding Metal Ion Binding Nuclear Retinoid X Receptor Binding Heterocyclic Compound Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Programmed Cell Death Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Inclusion Body Assembly Positive Regulation Of Proteasomal Protein Catabolic Process	Negative Regulation Of Transcription By RNA Polymerase II Ureteric Bud Development Glandular Epithelial Cell Development Outflow Tract Septum Morphogenesis Growth Plate Cartilage Development Regulation Of DNA-templated Transcription Apoptotic Process Signal Transduction Cell Population Proliferation Programmed Cell Death Striatum Development Neurogenesis Cell Differentiation Regulation Of Myelination Negative Regulation Of Chondrocyte Differentiation Embryonic Hindlimb Morphogenesis Multicellular Organism Growth Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Transcription By RNA Polymerase II Embryonic Eye Morphogenesis Retinoic Acid Receptor Signaling Pathway Embryonic Digestive Tract Development Ventricular Cardiac Muscle Cell Differentiation Bone Development Negative Regulation Of Cartilage Development Neural Precursor Cell Proliferation Stem Cell Proliferation Negative Regulation Of Stem Cell Proliferation
Pathways		Activation of NF-kappaB in B cells Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Vpu mediated degradation of CD4 Vif-mediated degradation of APOBEC3G SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of activated PAK-2p34 by proteasome mediated degradation Separation of Sister Chromatids FCERI mediated NF-kB activation Autodegradation of the E3 ubiquitin ligase COP1 Regulation of ornithine decarboxylase (ODC) ABC-family proteins mediated transport AUF1 (hnRNP D0) binds and destabilizes mRNA Asymmetric localization of PCP proteins Degradation of AXIN Degradation of DVL Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Regulation of RAS by GAPs TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling Defective CFTR causes cystic fibrosis MAPK6/MAPK4 signaling UCH proteinases Ub-specific processing proteases Assembly of the pre-replicative complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 G2/M Checkpoints Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A Ubiquitin-dependent degradation of Cyclin D The role of GTSE1 in G2/M progression after G2 checkpoint FBXL7 down-regulates AURKA during mitotic entry and in early mitosis RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Regulation of PTEN stability and activity Neddylation Regulation of expression of SLITs and ROBOs Interleukin-1 signaling Negative regulation of NOTCH4 signaling KEAP1-NFE2L2 pathway GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 Degradation of CDH1 Somitogenesis Antigen processing: Ubiquitination & Proteasome degradation Proteasome assembly Proteasome assembly GSK3B-mediated proteasomal degradation of PD-L1(CD274) SPOP-mediated proteasomal degradation of PD-L1(CD274) AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) Degradation of CRY and PER proteins Degradation of CRY and PER proteins Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	Nuclear Receptor transcription pathway Signaling by Retinoic Acid Activation of anterior HOX genes in hindbrain development during early embryogenesis
Drugs		None	Adapalene Acitretin Alitretinoin Tretinoin Tazarotene Etretinate Arotinoid acid Tamibarotene LGD-1550 Trifarotene
Diseases		None	Small cell lung cancer Non-small cell lung cancer
GWAS		No GWAS studies recorded	Adult body size ( 32376654 ) Adventurousness ( 30643258 ) Age at first birth ( 34211149 ) Age at first sexual intercourse ( 34211149 ) Airflow obstruction ( 22837378 ) Airway responsiveness in chronic obstructive pulmonary disease ( 25514360 ) Apolipoprotein A1 levels ( 32203549 ) Asthma ( 29273806 ) Bell's palsy ( 33602968 ) Blood urea nitrogen levels ( 31152163 ) BMI (adjusted for smoking behaviour) ( 28443625 ) BMI in smokers ( 28443625 ) Body mass index ( 28448500 28892062 25673413 ) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500 ) Body mass index (joint analysis main effects and smoking interaction) ( 28443625 ) Body mass index in physically active individuals ( 28448500 ) Body mass index in physically inactive individuals ( 28448500 ) Body size at age 10 ( 32376654 ) Calcium levels ( 25972035 ) Carotid intima media thickness in rheumatoid arthritis ( 30251476 ) Cataracts ( 34127677 ) Chronic obstructive pulmonary disease ( 28166215 30804561 ) Chronotype ( 30696823 ) Coffee consumption ( 31046077 ) Dental caries (decayed and filled deciduous teeth) ( 31533690 ) Dental caries (decayed and filled deciduous tooth surfaces) ( 31533690 ) Dentures ( 31235808 ) Dietary macronutrient intake ( 29988085 ) FEV1 ( 30804560 ) General risk tolerance (MTAG) ( 30643258 ) Glaucoma (primary open-angle) ( 29891935 33627673 ) Gout ( 22179738 ) Heel bone mineral density ( 30598549 28869591 ) Hip circumference adjusted for BMI ( 34021172 ) Intraocular pressure ( 29785010 31959993 ) Low susceptibility to hepatitis C infection ( 31206233 ) Lung function (FEV1/FVC) ( 30804560 ) Lung function (FVC) ( 30804560 ) Macular thickness ( 30535121 ) Mean corpuscular hemoglobin ( 32888494 ) Mean corpuscular volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Midgestational cytokine/chemokine levels (maternal genetic effect) ( 30134952 ) Molybdenum levels ( 26025379 ) Mood instability ( 31168069 ) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808 ) Obesity (extreme) ( 19553259 ) Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder ( 26184070 ) Optic disc area ( 31798171 28073927 25631615 ) Optic disc size ( 31809533 ) Optic nerve head parameters (multi-trait analysis) ( 31798171 ) Peak expiratory flow ( 30804560 ) Platelet distribution width ( 32888494 ) Post bronchodilator FEV1/FVC ratio ( 26634245 ) Pulmonary function ( 21946350 ) Pulmonary function (smoking interaction) ( 23284291 ) Pursuit maintenance gain ( 29064472 ) Refractive error ( 32231278 ) Smoking initiation (ever regular vs never regular) ( 30679032 ) Smoking status (ever vs never smokers) ( 30643258 ) Urinary sodium excretion ( 31409800 ) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993 ) Vertical cup-disc ratio (multi-trait analysis) ( 31959993 )
Interacting Genes		75 interacting genes: AKT1 AZIN2 BACH2 BFSP2 CAMK2A CCDC136 CDC42 CFAP206 EPHA8 ERCC3 ERCC6 ESR1 ESR2 ESRRA ESRRG FOS FXR1 GTF2B HARS1 HNF4G HOMER3 HSPA1A HTT INSIG2 KRT15 KRT27 KRT31 KRT38 KRT40 LAMB1 MDM2 MYO18B NR1H3 NR1I2 NR1I3 NR3C2 OGT PDC PDCL PLEKHO1 PPARD PRKN PSMC3 PSMC4 RAD23A RARA RARB RARG RORA RORB RORC RXRA SCOC SHOC2 SIRPA SKA1 SP1 SSNA1 SUMO2 TAF10 TFIP11 THAP11 THRB TNNI2 TNNI3 TNNT1 TP53 TPM1 TRIP11 UBE3C UBLCP1 USP4 VDR VIM XPC	24 interacting genes: ARID1A CCNDBP1 CCNH CEBPA CEBPB GATA3 HR MAP6 MEOX2 NCOA1 NCOA3 NCOR2 NRIP1 PNRC1 PPARGC1A PRKD2 PSMC5 RSPH1 RXRA RXRB RXRG SMAD2 SMARCD3 SMARCE1
Entrez ID		5705	5915
HPRD ID		03400	07183
Ensembl ID		ENSG00000087191	ENSG00000077092
Uniprot IDs		A0A140VJS3 P62195	A0A8I5KWP3 F1D8S6 P10826 Q3SB16 Q5QHG3 Q86UC5
PDB IDs		2KRK 3KW6 5GJQ 5GJR 5L4G 5LN3 5M32 5T0C 5T0G 5T0H 5T0I 5T0J 5VFP 5VFQ 5VFR 5VFS 5VFT 5VFU 5VGZ 5VHF 5VHH 5VHI 5VHJ 5VHM 5VHN 5VHO 5VHP 5VHQ 5VHR 5VHS 6MSB 6MSD 6MSG 6MSH 6MSJ 6MSK 6WJD 6WJN 7QXN 7QXP 7QXU 7QXW 7QXX 7QY7 7QYA 7QYB 7W37 7W38 7W39 7W3A 7W3B 7W3C 7W3F 7W3G 7W3H 7W3I 7W3J 7W3K 7W3M 8CVT 8JRI 8JRT 8JTI 8K0G 8USB 8USC 9E8G 9E8H 9E8I 9E8J 9E8K 9E8L 9E8N 9E8O 9E8Q	1HRA 1XAP 4DM6 4DM8 4JYG 4JYH 4JYI 5UAN 6SSQ
GO Terms Enriched among Interactors		Nuclear Receptor Activity Intracellular Receptor Signaling Pathway Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor-mediated Signaling Pathway Nuclear Steroid Receptor Activity Hormone-mediated Signaling Pathway Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Intracellular Signal Transduction Cell Differentiation Positive Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Chromatin Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Cellular Developmental Process Retinoic Acid Receptor Signaling Pathway Developmental Process RNA Polymerase II Transcription Regulator Complex DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Nucleoplasm Positive Regulation Of Macromolecule Metabolic Process Cellular Response To Oxygen-containing Compound RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Estrogen Response Element Binding Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Nucleus Response To Lipid Regulation Of RNA Biosynthetic Process Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process DNA Binding Transcription By RNA Polymerase II MRNA Transcription Regulation Of Primary Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Response To Hormone Stimulus Intermediate Filament Organization Positive Regulation Of Proteasomal Protein Catabolic Process	Chromatin Nuclear Receptor Binding Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Nucleus Positive Regulation Of Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Developmental Process Positive Regulation Of Multicellular Organismal Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process RNA Polymerase II Transcription Regulator Complex Retinoic Acid Receptor Signaling Pathway Regulation Of Primary Metabolic Process DNA-templated Transcription Retinoic Acid-responsive Element Binding DNA Binding Transcription Coactivator Activity Positive Regulation Of Metabolic Process Positive Regulation Of Cell Differentiation Chromatin DNA Binding Sequence-specific DNA Binding Regulation Of Metabolic Process DNA-binding Transcription Factor Binding Nuclear Receptor-mediated Signaling Pathway Response To Lipid Nuclear Glucocorticoid Receptor Binding Brahma Complex Transcription Coregulator Activity NpBAF Complex Regulation Of Multicellular Organismal Development NBAF Complex Nuclear Retinoic Acid Receptor Binding Nucleobase-containing Compound Biosynthetic Process Hormone-mediated Signaling Pathway Nuclear Retinoid X Receptor Binding C/EBP Complex DNA-binding Transcription Factor Activity Nucleosome Disassembly